A novel magnetic fluorescent biosensor based on graphene quantum dots for rapid, efficient, and sensitive separation and detection of circulating tumor cells

Cui, Fangchao; Ji, Jian; Sun, Jiadi; Wang, Jun; Wang, Haiming; Zhang, Yinzhi; Ding, Hong; Yong, Lu; Xu, Dongwei; Sun, Xiulan

doi:10.1007/s00216-018-1501-0

Cited by 86 publications

(28 citation statements)

References 34 publications

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“…In 2019, Cui et al introduced a concept of a 'turn-on' magnetic fluorescent biosensor ( Figure 3) using molybdenum disulfide (MoS 2 ) nanosheets, Fe 3 O 4 and GQDs for detecting circulating tumor cells (CTCs) [104]. In this approach, electrochemically synthesized GQDs were modified with a magnetic agent and EpCAM (epithelial cell adhesion molecule) aptamer.…”

Section: Fluorescence-based Gqd Sensorsmentioning

confidence: 99%

Applications of Graphene Quantum Dots in Biomedical Sensors

Mansuriya

Altıntaş

2020

Sensors

177

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Due to the proliferative cancer rates, cardiovascular diseases, neurodegenerative disorders, autoimmune diseases and a plethora of infections across the globe, it is essential to introduce strategies that can rapidly and specifically detect the ultralow concentrations of relevant biomarkers, pathogens, toxins and pharmaceuticals in biological matrices. Considering these pathophysiologies, various research works have become necessary to fabricate biosensors for their early diagnosis and treatment, using nanomaterials like quantum dots (QDs). These nanomaterials effectively ameliorate the sensor performance with respect to their reproducibility, selectivity as well as sensitivity. In particular, graphene quantum dots (GQDs), which are ideally graphene fragments of nanometer size, constitute discrete features such as acting as attractive fluorophores and excellent electro-catalysts owing to their photo-stability, water-solubility, biocompatibility, non-toxicity and lucrativeness that make them favorable candidates for a wide range of novel biomedical applications. Herein, we reviewed about 300 biomedical studies reported over the last five years which entail the state of art as well as some pioneering ideas with respect to the prominent role of GQDs, especially in the development of optical, electrochemical and photoelectrochemical biosensors. Additionally, we outline the ideal properties of GQDs, their eclectic methods of synthesis, and the general principle behind several biosensing techniques.

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Section: Fluorescence-based Gqd Sensorsmentioning

confidence: 99%

Applications of Graphene Quantum Dots in Biomedical Sensors

Mansuriya

Altıntaş

2020

Sensors

177

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“…An aptamer-based graphene QDs/Fe 3 O 4 assembly in combination with molybdenumdisulfide (MoS 2 ) nanosheets as fluorescence quencher were used for the enrichment and detection of as low as 10 CTCs/blood sample [151]. Also, QDs in combination with magnetic nanoparticles was used for the isolation of CTCs captured by immobilized aptamers.…”

Section: Quantum Dots (Qds)mentioning

confidence: 99%

Nanotechnology in emerging liquid biopsy applications

Kalogianni

2021

Nano Convergence

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Liquid biopsy is considered as the most attractive alternative to traditional tissue biopsies. The major advantages of this approach lie in the non-invasive procedure, the rapidness of sample collection and the potential for early cancer diagnosis and real-time monitoring of the disease and the treatment response. Nanotechnology has dynamically emerged in a wide range of applications in the field of liquid biopsy. The benefits of using nanomaterials for biosensing include high sensitivity and detectability, simplicity in many cases, rapid analysis, the low cost of the analysis and the potential for portability and personalized medicine. The present paper reports on the nanomaterial-based methods and biosensors that have been developed for liquid biopsy applications. Most of the nanomaterials used exhibit great analytical performance; moreover, extremely low limits of detection have been achieved for all studied targets. This review will provide scientists with a comprehensive overview of all the nanomaterials and techniques that have been developed for liquid biopsy applications. A comparison of the developed methods in terms of detectability, dynamic range, time-length of the analysis and multiplicity, is also provided.

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“…Carbon dots, including carbon quantum dots and graphene quantum dots (GQDs), have drawn numerous attention due to their tunable photoluminescent properties and high photostability. Cui et al developed a magnetic fluorescent biosensor based on nitrogen and sulfur-doped graphene quantum dots (N,S/GQDs) and molybdenum disulfide (MoS 2 ) nanosheets [83]. In this work, GQDs were bound to the aptamer-functionalized magnetic NPs (aptamer@Fe 3 O 4 @GQD) for one-step bioimaging and enrichment, in which MoS 2 nanosheets were employed to quench the fluorescence.…”

Section: Luminescent Nanomaterialsmentioning

confidence: 99%

Recent Development of Nanomaterials-Based Cytosensors for the Detection of Circulating Tumor Cells

2021

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The accurate analysis of circulating tumor cells (CTCs) holds great promise in early diagnosis and prognosis of cancers. However, the extremely low abundance of CTCs in peripheral blood samples limits the practical utility of the traditional methods for CTCs detection. Thus, novel and powerful strategies have been proposed for sensitive detection of CTCs. In particular, nanomaterials with exceptional physical and chemical properties have been used to fabricate cytosensors for amplifying the signal and enhancing the sensitivity. In this review, we summarize the recent development of nanomaterials-based optical and electrochemical analytical techniques for CTCs detection, including fluorescence, colorimetry, surface-enhanced Raman scattering, chemiluminescence, electrochemistry, electrochemiluminescence, photoelectrochemistry and so on.

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A novel magnetic fluorescent biosensor based on graphene quantum dots for rapid, efficient, and sensitive separation and detection of circulating tumor cells

Cited by 86 publications

References 34 publications

Applications of Graphene Quantum Dots in Biomedical Sensors

Applications of Graphene Quantum Dots in Biomedical Sensors

Nanotechnology in emerging liquid biopsy applications

Recent Development of Nanomaterials-Based Cytosensors for the Detection of Circulating Tumor Cells

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