Moo Rim Kang, Jong Soon Kang, Sang-Bae Han, Jang Hyun Kim, Dong-Myung Kim, Kiho Lee, Chang Woo Lee, Ki Hoon Lee, Chul Ho Lee, Gyoonhee Han, Jong Seong Kang, Hwan Mook Kim, Song-Kyu Park
Abstract:In this study, we investigated the anti-tumor activity of KBH-A42 [N-hydroxy-3-(2-oxo-1-(3-phenylpropyl)-1,2,5,6-tetrahydropyridin-3-yl)propanamide], a novel synthetic histone deacetylase (HDAC) inhibitor. KBH-A42 inhibited a variety of HDAC isoforms in enzyme assays and suppressed growth of various cancer cell lines. Among the cell lines examined, colon cancer cells, including SW620, SW480 and HCT-15, were the cell types most sensitive to KBH-A42. KBH-A42 inhibition of cancer cell growth was comparable to or …
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