A novel immunotherapy of Brucellosis in cows monitored non invasively through a specific biomarker

Saxena, Hari Mohan; Raj, Sugandha

doi:10.1371/journal.pntd.0006393

Cited by 17 publications

(20 citation statements)

References 26 publications

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“…This combination of doxycycline and rifampicin has also been proven experimentally [ 112 ]. As a result of continued efforts by the scientific community to develop an effective therapeutics, Caryopteris mongolica Bunge (Lamiaceae) has been tested in combination with doxycycline [ 113 , 114 ]. Despite the fact that several therapeutics are in practice which makes the disease manageable, an effective therapeutic is required for the complete treatment of brucellosis.…”

Section: Treatment Of Brucellosismentioning

confidence: 99%

“…S19 and RB51 are live attenuated vaccines derived from B. abortus [ 126 ]. A cocktail lysate of S19 and RB51 was also tested as an immune-therapy to treat the bracelet infected cattle [ 114 ]. DNA vaccines have also been tested and show promising results when compared with S19 and RB51; however, several boosters were required to achieve the desired immunity [ 127 , 128 ].…”

Section: Vaccination Against Brucellosismentioning

confidence: 99%

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An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

2018

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Brucellosis is one of the most common contagious and communicable zoonotic diseases with high rates of morbidity and lifetime sterility. There has been a momentous increase over the recent years in intra/interspecific infection rates, due to poor management and limited resources, especially in developing countries. Abortion in the last trimester is a predominant sign, followed by reduced milk yield and high temperature in cattle, while in humans it is characterized by undulant fever, general malaise, and arthritis. While the clinical picture of brucellosis in humans and cattle is not clear and often misleading with the classical serological diagnosis, efforts have been made to overcome the limitations of current serological assays through the development of PCR-based diagnosis. Due to its complex nature, brucellosis remains a serious threat to public health and livestock in developing countries. In this review, we summarized the recent literature, significant advancements, and challenges in the treatment and vaccination against brucellosis, with a special focus on developing countries.

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Section: Treatment Of Brucellosismentioning

confidence: 99%

Section: Vaccination Against Brucellosismentioning

confidence: 99%

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

2018

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“…Among these two phage lysates, RL projected stronger cell-mediated immune response while SL stimulated higher level of humoral immune response. Results of the study are promising to encourage the use of bacteriophage lysates in treatment of bovine brucellosis (Saxena and Raj 2018 ).…”

Section: Treatmentmentioning

confidence: 95%

Bovine brucellosis – a comprehensive review

Khurana

Sehrawat

Tiwari

et al. 2021

Veterinary Quarterly

137

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Brucellosis is a zoonotic disease of great animal welfare and economic implications worldwide known since ancient times. The emergence of brucellosis in new areas as well as transmission of brucellosis from wild and domestic animals is of great significance in terms of new epidemiological dimensions. Brucellosis poses a major public health threat by the consumption of non-pasteurized milk and milk products produced by unhygienic dairy farms in endemic areas. Regular and meticulous surveillance is essentially required to determine the true picture of brucellosis especially in areas with continuous high prevalence. Additionally, international migration of humans, animals and trade of animal products has created a challenge for disease spread and diagnosis in non-endemic areas. Isolation and identification remain the gold standard test, which requires expertise. The advancement in diagnostic strategies coupled with screening of newly introduced animals is warranted to control the disease. Of note, the diagnostic value of miRNAs for appropriate detection of B. abortus infection has been shown. The most widely used vaccine strains to protect against Brucella infection and related abortions in cattle are strain 19 and RB51. Moreover, it is very important to note that no vaccine, which is highly protective, safe and effective is available either for bovines or human beings. Research results encourage the use of bacteriophage lysates in treatment of bovine brucellosis. One Health approach can aid in control of this disease, both in animals and man.

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“…Al-Ajlan et al, (2011) compared the DNA and RNA detection PCR methods for identifying Brucella species in human blood samples. Saxena and Raj (2018) employed RT-PCR for monitoring and assessment of efficacy of immunotherapy against Brucellosis in cattle.…”

Section: Rt-pcrmentioning

confidence: 99%

Clinical, Serological and Molecular Diagnosis of Brucellosis in Domestic Animals

Joshi¹

2021

Int.J.Curr.Microbiol.App.Sci

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Animals that are mostly infected by this bacterium include cattle, goats, sheep, dogs, pigs and camels among others. Humans act as accidental host to this disease while animals are its natural reservoirs (CDC, 2019). In animals, it leads to abortion, stillbirth, epididymitis, orchitis and placentitis (OIE, 2009). Early and accurate diagnosis is the key to control Brucellosis. Here we discuss various aspects of diagnosis of Brucellosis in domestic animals. Aetiology of BrucellosisBrucellosis is caused by bacteria of the genus Brucella. There are six main species of Brucella. They are B. suis, B. abortus, B. melitensis, B. ovis, B. neotomae, and B. canis (WHO, 2006). Some of these are pathogenic to man as well. They are B. canis, B. abortus, B. suis, and B. melitensis in the ascending order of pathogenicity (Corbel, 2006). Different species of Brucella infect different animals, for example B. canis is infectious to canines, cattle is infected by B. abortus, sheep are infected by B. ovis and B. melitensis, goats and camels by B. melitensis, swine by B. suis

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A novel immunotherapy of Brucellosis in cows monitored non invasively through a specific biomarker

Cited by 17 publications

References 26 publications

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

Bovine brucellosis – a comprehensive review

Clinical, Serological and Molecular Diagnosis of Brucellosis in Domestic Animals

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