A novel hemicyanine-based near-infrared fluorescent probe for Hg2+ ions detection and its application in living cells imaging

Wang, Yang; Hou, Xufeng; Li, Zhensheng; Liu, Chunhui; Hu, Shanshan; Li, Chenming; Xu, Zheng; Wang, Yuan

doi:10.1016/j.dyepig.2019.107951

Cited by 26 publications

(8 citation statements)

References 44 publications

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“… 50 , 51 The detection limit was found to be 4.0 × 10 –8 M, which is smaller than that of previous Hg 2+ fluorescent probes. 19 , 22 , 35 , 52 − 54 The above results prove that probe 1 can be applied for quantitative determination of Hg 2+ .…”

Section: Resultssupporting

confidence: 59%

“…Here, F denotes the fluorescence intensity of probe 1 at 510 nm, C stands for the concentration of Hg 2+ , and r indicates the linear correlation coefficient. The detection limit was determined to be 3 S B / m (where S B represents the standard deviation of 10 blank measurements and m is the slope of the calibrated line). , The detection limit was found to be 4.0 × 10 –8 M, which is smaller than that of previous Hg 2+ fluorescent probes. ,,,− The above results prove that probe 1 can be applied for quantitative determination of Hg 2+ .…”

Section: Resultsmentioning

confidence: 73%

“…However, only part of the measurement is based on the fluorescence enhancement principle for mercury ions. 22 − 28 Therefore, the design of a fluorescence-enhanced Hg 2+ probe with high selectivity and sensitivity has great prospects and challenges.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, most fluorescent probes for the determination of mercury ions are designed by the inspiration of the fluorescence quenching mechanism − and their sensitivity is lower than that of enhanced probes. However, only part of the measurement is based on the fluorescence enhancement principle for mercury ions. − Therefore, the design of a fluorescence-enhanced Hg 2+ probe with high selectivity and sensitivity has great prospects and challenges.…”

Section: Introductionmentioning

confidence: 99%

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A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

Tian

Wang

et al. 2020

ACS Omega

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Hg 2+ has a significant hazardous impact on the environment and ecosystem. There is a great demand for new methods with high selectivity and sensitivity to determine mercury in life systems and environments. In this paper, a novel turn-on Hg 2+ fluorescent probe has been reported with a naphthalimide group. The Hg 2+ fluorescent probe was designed by the inspiration of the well-known specific Hg 2+ -triggered thioacetal deprotection reaction. A 1,2-dithioalkyl group was chosen as the specific recognition site of Hg 2+ . The probe showed weak fluorescence without Hg 2+ , and the color of the solution was light yellow. In the presence of Hg 2+ , the probe reacted specifically with the mercury ion to produce an aldehyde and emitted strong fluorescence, and the color of the solution also turned light green, thus realizing the monitoring of the mercury ion. The Hg 2+ fluorescent probe showed outstanding sensitivity and selectivity toward Hg 2+ . Furthermore, the Hg 2+ fluorescent probe could work in a wide pH range. The linear relationship between the fluorescence intensity at 510 nm and the concentration of Hg 2+ was obtained in a range of Hg 2+ concentration from 2.5 × 10 –7 to 1.0 × 10 –5 M. The detection limit was found to be 4.0 × 10 –8 M for Hg 2+ . Furthermore, with little cell toxicity, the probe was successfully applied to the confocal image of Hg 2+ in PC-12 cells.

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Section: Resultssupporting

confidence: 59%

Section: Resultsmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

Tian

Wang

et al. 2020

ACS Omega

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“…9). 142 Density functional theory (DFT) calculations indicated that the ICT process was restrained through the introduction of the dithioacetal group to the ortho-position hydroxyl to give a 2.3974 eV energy gap between the LUMO and HOMO level. In contrast, the presence of Hg 2+ could trigger the cleavage of thioacetal and result in the formation of aldehyde, which produced a strong ICT process with an increased energy gap (2.4281 eV), leading to enhancement of fluorescence intensity at 710 nm.…”

Section: Nir Fluorescent Probes For Ionic Speciesmentioning

confidence: 99%

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

et al. 2022

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A Simple Fluorescence Turn‐on Probe for the Detection of Hg²⁺ Ion in Aqueous Solution and Soil With AIE and ICT Mechanisms

Liao

Xue

et al. 2020

Bulletin Korean Chem Soc

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A novel fluorescent probe TSA for the high selectivity of mercury (Hg2+) ion has been explored, which was obtained by two‐step synthesis. Probe TSA was barely emissive in HEPES buffer. In the presence of Hg2+ ion, the dithioacetal unit in probe TSA was hydrolyzed to be formyl group, consequently causing the intense sky‐blue emission via aggregation‐induced emission and intramolecular charge transfer mechanisms. Moreover, probe TSA was potential to detect Hg2+ ion in dyeing wastewater and clay soil.

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A novel hemicyanine-based near-infrared fluorescent probe for Hg2+ ions detection and its application in living cells imaging

Cited by 26 publications

References 44 publications

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

A Simple Fluorescence Turn‐on Probe for the Detection of Hg²⁺ Ion in Aqueous Solution and Soil With AIE and ICT Mechanisms

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A novel hemicyanine-based near-infrared fluorescent probe for Hg2+ ions detection and its application in living cells imaging

Cited by 26 publications

References 44 publications

A Highly Selective Fluorescent Probe for Hg2+ Based on a 1,8-Naphthalimide Derivative

A Highly Selective Fluorescent Probe for Hg2+ Based on a 1,8-Naphthalimide Derivative

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

A Simple Fluorescence Turn‐on Probe for the Detection of Hg2+ Ion in Aqueous Solution and Soil With AIE and ICT Mechanisms

Contact Info

Product

Resources

About

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

A Highly Selective Fluorescent Probe for Hg²⁺ Based on a 1,8-Naphthalimide Derivative

A Simple Fluorescence Turn‐on Probe for the Detection of Hg²⁺ Ion in Aqueous Solution and Soil With AIE and ICT Mechanisms