A Novel Formulation for Superparamagnetic Iron Oxide (SPIO) Particles Enhancing MR Lymphography: Comparison of Physicochemical Properties and The In Vivo Behaviour

Lind, Kathrin; Kresse, Mayk; Debus, Nils; Müller, Rainer H.

doi:10.1080/10611860290022651

Cited by 74 publications

(45 citation statements)

References 31 publications

(39 reference statements)

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“…82,86,95,155 Specifically, the SPIO extravasate from the vasculature to the interstitial space where they are transported to the lymph nodes via the lymphatic vessels. The absence of SPIO in lymph nodes as determined by MR imaging has been shown to correlate with disturbances in lymph node flow or architecture due to the presence of metastases.…”

Section: Lymph Node Imagingmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

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Abstract-The field of molecular imaging has recently seen rapid advances in the development of novel contrast agents and the implementation of insightful approaches to monitor biological processes non-invasively. In particular, superparamagnetic iron oxide nanoparticles (SPIO) have demonstrated their utility as an important tool for enhancing magnetic resonance contrast, allowing researchers to monitor not only anatomical changes, but physiological and molecular changes as well. Applications have ranged from detecting inflammatory diseases via the accumulation of non-targeted SPIO in infiltrating macrophages to the specific identification of cell surface markers expressed on tumors. In this article, we attempt to illustrate the broad utility of SPIO in molecular imaging, including some of the recent developments, such as the transformation of SPIO into an activatable probe termed the magnetic relaxation switch.

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Section: Lymph Node Imagingmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

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“…In this way, USPIONs are used as contrast for lymphography 44,45 and angiography, 46,47 as a bone marrow contrast, or as a perfusion agent in brain and kidney.…”

mentioning

confidence: 99%

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Estelrich¹,

Sánchez-Martín²,

Busquets³

2015

IJN

276

106

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Magnetic resonance imaging (MRI) has become one of the most widely used and powerful tools for noninvasive clinical diagnosis owing to its high degree of soft tissue contrast, spatial resolution, and depth of penetration. MRI signal intensity is related to the relaxation times ( T 1 , spin–lattice relaxation and T 2 , spin–spin relaxation) of in vivo water protons. To increase contrast, various inorganic nanoparticles and complexes (the so-called contrast agents) are administered prior to the scanning. Shortening T 1 and T 2 increases the corresponding relaxation rates, 1/ T 1 and 1/ T 2 , producing hyperintense and hypointense signals respectively in shorter times. Moreover, the signal-to-noise ratio can be improved with the acquisition of a large number of measurements. The contrast agents used are generally based on either iron oxide nanoparticles or ferrites, providing negative contrast in T 2 -weighted images; or complexes of lanthanide metals (mostly containing gadolinium ions), providing positive contrast in T 1 -weighted images. Recently, lanthanide complexes have been immobilized in nanostructured materials in order to develop a new class of contrast agents with functions including blood-pool and organ (or tumor) targeting. Meanwhile, to overcome the limitations of individual imaging modalities, multimodal imaging techniques have been developed. An important challenge is to design all-in-one contrast agents that can be detected by multimodal techniques. Magnetoliposomes are efficient multimodal contrast agents. They can simultaneously bear both kinds of contrast and can, furthermore, incorporate targeting ligands and chains of polyethylene glycol to enhance the accumulation of nanoparticles at the site of interest and the bioavailability, respectively. Here, we review the most important characteristics of the nanoparticles or complexes used as MRI contrast agents.

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“…In another study, Mao et al evaluated the effect of polycaprolactone coating on the cytotoxicity of gold nanoparticles, and they found that polycaprolactonecoated gold nanoparticles had much less cytotoxicity than bare gold nanoparticles (Mao et al, 2007). It was also pointed out that surface coatings reduce the aggregation and toxicity of magnetic nanoparticles (Lind et al, 2002;Zavisova et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

The comparison of antioxidant capacity and cytotoxic, anticarcinogenic,and genotoxic effects of Fe@Au nanosphere magnetic nanoparticles

Yegenoglu¹,

Aslım²,

Güven³

et al. 2017

Turk J Biol

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Magnetic gold nanoparticles are used in various biomedical, biochemistry, and biotechnology applications due to their controllable size distribution, long-term stability, reduced toxicity, and biocompatibility. Different coating materials, such as proteins, carbohydrates, lipids, and polyphenols, are applied to enhance the biocompatibility of nanoparticles. In this study, the effects of surface coatings of core-shell structured Fe@Au nanosphere magnetic nanoparticles with regard to antioxidant capacity and cytotoxic, anticarcinogenic, and genotoxic properties were investigated. The obtained results demonstrated that avidin-coated Fe@Au nanospheres had higher antioxidant capacities than uncoated nanospheres. Neither avidin-coated nor uncoated nanoparticles had a cytotoxic effect on normal cells (human gingival fibroblast cell line, HGF-1). In addition, they had anticarcinogenic effects on human cervical carcinoma (HeLa), human breast adenocarcinoma (MCF-7), and human colorectal adenocarcinoma (CCL-221). The genotoxic effects of nanoparticles were also evaluated with DNA tail damage ratio.

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A Novel Formulation for Superparamagnetic Iron Oxide (SPIO) Particles Enhancing MR Lymphography: Comparison of Physicochemical Properties and The In Vivo Behaviour

Cited by 74 publications

References 31 publications

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

The comparison of antioxidant capacity and cytotoxic, anticarcinogenic,and genotoxic effects of Fe@Au nanosphere magnetic nanoparticles

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