2018
DOI: 10.1016/j.neuropharm.2017.11.007
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Abstract: Neuropathy is a common complication of long-term diabetes. Proposed mechanisms of neuronal damage caused by diabetes that are downstream of hyperglycemia and/or loss of insulin signaling include ischemic hypoxia, inflammation and loss of neurotrophic support. The curcumin derivative J147 is a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neurop… Show more

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Cited by 51 publications
(38 citation statements)
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References 45 publications
(62 reference statements)
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“…In addition, curcumin and tetrahydrocurcumin improved the SFI score and locomotor coordination in a vincristine-induced PN, in male swiss mouse and Wistar rat respectively [ 42 , 43 ]. Curcumin also allowed a faster recovery of locomotor activity in CCI model [ 54 ], of locomotor coordination in alcohol-induced neuropathy [ 62 ] and in DPN models [ 67 ]. Curcumin improved locomotor coordination, walking track analysis, finger spacing, muscular strength, and skilled locomotion in traumatic neuropathies induced by sciatic nerve crush or transection in male SD rats [ 34 , 66 ], in female Wistar rats [ 68 ], and in male Wistar rats [ 69 ].…”
Section: Curcumin Studies In Animal Models Of Pnmentioning
confidence: 99%
“…In addition, curcumin and tetrahydrocurcumin improved the SFI score and locomotor coordination in a vincristine-induced PN, in male swiss mouse and Wistar rat respectively [ 42 , 43 ]. Curcumin also allowed a faster recovery of locomotor activity in CCI model [ 54 ], of locomotor coordination in alcohol-induced neuropathy [ 62 ] and in DPN models [ 67 ]. Curcumin improved locomotor coordination, walking track analysis, finger spacing, muscular strength, and skilled locomotion in traumatic neuropathies induced by sciatic nerve crush or transection in male SD rats [ 34 , 66 ], in female Wistar rats [ 68 ], and in male Wistar rats [ 69 ].…”
Section: Curcumin Studies In Animal Models Of Pnmentioning
confidence: 99%
“…A PubMed search identified one other published article showing similar results. 34 Unknown factors may have resulted in the lack of differences in the PWTL between the NW and DW groups.…”
Section: Discussionmentioning
confidence: 99%
“…leaf, are effective in animal models of DPN; however, these treatments have not been validated in clinical trials. 46 , 47 ALA and epalrestat are efficacious in DPN patients and are popular in clinical use. 48 , 49 Many RCTs, especially in recent years, have confirmed that a combination of ALA and epalrestat improves MNCV and SNCV in DPN patients more efficiently than monotherapies.…”
Section: Discussionmentioning
confidence: 99%