2016
DOI: 10.1016/j.inoche.2015.12.013
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Abstract: A novel complex, [Cu(acetylethTSC)Cl]Cl•0.25C2H5OH 1 (where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. In vitro studies showed that complex 1 acted as a poison inhibitor of human topoisomerase IIα, which may account for the observed anti-cancer effects.

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Cited by 39 publications
(16 citation statements)
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“…[103] Desideri et al reported a copper(II) complex with oxindolimine that could fully inhibit the relaxation of topoisomerase Iβ at 50 µm concentration as a catalytic inhibitor rather than a poison. Holder et al identified a copper(II) complex with a thiosemicarbazone which acted as a human topoisomerase IIα poison and displayed significant anti-proliferative activity against various colon and aggressive breast cancer cell lines.…”
Section: Copper Complexes For Topoisomerase Inhibitionmentioning
confidence: 99%
“…[103] Desideri et al reported a copper(II) complex with oxindolimine that could fully inhibit the relaxation of topoisomerase Iβ at 50 µm concentration as a catalytic inhibitor rather than a poison. Holder et al identified a copper(II) complex with a thiosemicarbazone which acted as a human topoisomerase IIα poison and displayed significant anti-proliferative activity against various colon and aggressive breast cancer cell lines.…”
Section: Copper Complexes For Topoisomerase Inhibitionmentioning
confidence: 99%
“…The methods used to synthesize these compounds are validated and are routinely been used in the biochemistry laboratory [31]. at all concentrations (1, 10 and100 µM) in comparison to DMSO-treated control (Fig.…”
Section: Synthesis Of Citralettsc025c 2 H 5 Oh 3 (Compound 3)mentioning
confidence: 99%
“…The increasing life pressure and environmental pollution have led to many serious diseases in the human beings. Among these decreases, cancer is the most life‐threatening disease that causes millions of people deaths every year . Currently, chemotherapy is still the dominant treatment method for most cancers especially for malignant tumor.…”
Section: Introductionmentioning
confidence: 99%