2021
DOI: 10.1186/s13287-021-02554-9
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Abstract: Background In human subcutaneous adipose tissue, the superficial fascia distinguishes superficial and deep microenvironments showing extensions called retinacula cutis. The superficial subcutaneous adipose tissue has been described as hyperplastic and the deep subcutaneous adipose tissue as inflammatory. However, few studies have described stromal-vascular fraction (SVF) content and adipose-derived stromal/stem cells (ASCs) behavior derived from superficial and deep subcutaneous adipose tissue.… Show more

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Cited by 6 publications
(1 citation statement)
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“…Furthermore, our new results on the distribution of LVs may improve the comprehension of clinical manifestations of impaired lymphatic transport. Several authors have already revisited the anatomy of the lymphatic system, reliably identifying the lymphatic collectors and venules [ 34 , 35 , 36 ], but we think that the knowledge of the strong relationships between fibrous elements of the subcutaneous tissues [ 9 , 37 ] and LVs could better improve the clinical and ultrasound evaluation of lymphedema and, consequently, improve targeted therapies, as well as suggesting modifications of manual lymphatic drainage techniques in postoperative subjects. It is well known that lymphedema can induce complications such as inflammation [ 38 ], fat tissue hypertrophy, and fibrosis [ 4 , 10 ], and the subcutaneous alterations [ 39 ] can alter the environment around the LVs, increasing their collapsibility.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, our new results on the distribution of LVs may improve the comprehension of clinical manifestations of impaired lymphatic transport. Several authors have already revisited the anatomy of the lymphatic system, reliably identifying the lymphatic collectors and venules [ 34 , 35 , 36 ], but we think that the knowledge of the strong relationships between fibrous elements of the subcutaneous tissues [ 9 , 37 ] and LVs could better improve the clinical and ultrasound evaluation of lymphedema and, consequently, improve targeted therapies, as well as suggesting modifications of manual lymphatic drainage techniques in postoperative subjects. It is well known that lymphedema can induce complications such as inflammation [ 38 ], fat tissue hypertrophy, and fibrosis [ 4 , 10 ], and the subcutaneous alterations [ 39 ] can alter the environment around the LVs, increasing their collapsibility.…”
Section: Discussionmentioning
confidence: 99%