A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway

Tanshinone IIA enhances chemosensitivity of colon cancer cells by suppressing nuclear factor-κB

“…In addition, Fu et al (25) found that TSA blocked the epithelial-mesenchymal transition through the downregulation of hypoxia-inducible factor-1α, reversing hypoxia-induced chemotherapy resistance in breast cancer cell lines. In addition, increasing evidence indicated that TSA can inhibit tumor cell growth and induce apoptosis (15,17,43); however, despite the fact that in certain type of cancer evidence showed that intrinsic apoptosis pathways were involved (14,44) (46) found that TSA potentiated the efficacy of 5-FU in colon cancer cells in vivo through the downregulation of P-glycoprotein and LC3-II. The results of the present study confirmed the antitumor activity and chemosensitizing effect of TSA in colon cancer cells and provided new evidence that TSA can sensitize colon cancer cells to 5-FU through the suppression of NF-κB activation.…”

Economic analysis in product design — A case study of a TCM dietary supplement

“…TCMs are widely accepted in the market due to their long history of treating and preventing ailments and research results in recent years have proved their efficacy on treating various diseases such as cancer and hepatitis [21][22][23][24]. TCMs are customarily delivered in liquid form by boiling a single herb or multiple herbs in water according to a traditional recipe, while most modern TCMs, particularly dietary supplements, are delivered in solid or liquid form after extracting the bioactive ingredients from the herbal decoction.…”

Molecular and Celluar Mechanism Studies on Anticancer Effects of Chinese Medicines

“…Furthermore, other tanshinones, such as sibiriquinone A, sibiriquinone B, cryptotanshinone, and dihydrotanshinone I possess the anticancer activity partly through inhibition of HIF-1 accumulation (Dat et al, 2007). Recentlly, a novel compound, acetyltanshinone IIA (ATA) was obtained from chemical modifications of tanshinone TIIA (TIIA) which shows a higher growth inhibition ability on breast cancer especially HER2 positive cells than normal cells and it inhibites xenografted tumor growth in mice due to significant reactive oxygen species (ROS) generation, Bax translocation to mitochondria, resulting in mitochondria damage, cytochrome c release, caspase-3 activation and apoptotic cell death (Tian et al, 2010). Denshen has low toxicity and less side effects in clinical practice.…”