“…Some compounds were purified by preparative HPLC using a Shimadzu preparative LC-20A Prominence (Shimadzu, Kyoto, Japan) with the following conditions: column, Luna (10μ C18(2) 100 Å; 250 × 21.2 mm; Phenomenex, Torrance, CA, U.S.A.); mobile phase, linear gradient from 50% ACN to 90% within 10 min, 90% ACN for 5 min, linear gradient from 90% ACN to 50% within 1 min, 50% 37 as well as physicochemical 20 and PK parameters for 2 were derived from the literature. 22,25,38 28 3-(4-Phenyloxazol-2-yl)propanoic Acid (10). 4-Oxo-4-(2-oxo-2phenylethoxy)butanoic acid (133, 1.24 g, 5.23 mmol, 1.00 equiv), acetamide (1.56 g, 26.1 mmol, 5.00 equiv), and BF 3 •Et 2 O (0.740 g, 5.23 mmol, 1.00 equiv) were mixed and stirred at 140 °C for 16 h. After cooling to rt, aqueous hydrochloric acid (10%, 30 mL) was added and the mixture was extracted with EtOAc (3 × 30 mL).…”