A novel canine model for prostate cancer

Keller, Jill M.; Schade, George R.; Ives, Kimberly; Cheng, Xu; Rosol, Thomas J.; Piert, Morand; Siddiqui, Javed; Roberts, William W.; Keller, Evan T.

doi:10.1002/pros.22642

Cited by 41 publications

(54 citation statements)

References 25 publications

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“…56,96 Chemically immunosuppressed laboratory dogs have become established as orthotopic cancer models, particularly in prostate cancer research. 3,55 While the availability and cost often preclude the use of chemically immunosuppressed dogs in cancer research, their use as orthotopic models of bone metastasis can be valuable compared with rodents, particularly for translational in vivo imaging and treatment studies. Cats have a unique form of spontaneous bone metastasis in which pulmonary adenocarcinomas may metastasize to the bones of the digits.…”

Section: Animal Species Used For Bone Metastasis Researchmentioning

confidence: 99%

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Animal Models of Bone Metastasis

et al. 2015

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Bone is one of the most common sites of cancer metastasis in humans and is a significant source of morbidity and mortality. Bone metastases are considered incurable and result in pain, pathologic fracture, and decreased quality of life. Animal models of skeletal metastases are essential to improve the understanding of the molecular pathways of cancer metastasis and growth in bone and to develop new therapies to inhibit and prevent bone metastases. The ideal animal model should be clinically relevant, reproducible, and representative of human disease. Currently, an ideal model does not exist; however, understanding the strengths and weaknesses of the available models will lead to proper study design and successful cancer research. This review provides an overview of the current in vivo animal models used in the study of skeletal metastases or local tumor invasion into bone and focuses on mammary and prostate cancer, lymphoma, multiple myeloma, head and neck squamous cell carcinoma, and miscellaneous tumors that metastasize to bone.

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Section: Animal Species Used For Bone Metastasis Researchmentioning

confidence: 99%

“…13). 55 The dogs develop prostate tumors that can be used for molecular imaging and focal therapy research. 116 Metastases have also occurred in lymph nodes and the lungs.…”

Section: Animal Modelsmentioning

confidence: 99%

Animal Models of Bone Metastasis

et al. 2015

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“…For example, lique faction of tissue during histotripsy, in contrast to ther mal necrosis, can facilitate easier removal of destroyed tissue debris from the body. Recent preclinical histot ripsy trials on hyperplasia of the prostate gland (ade noma) in a dog model have shown that the destroyed tissue was removed through the excretory system over the course of several days [13]. To To develop HIFU protocols that utilize shock wave action on tissue, it is necessary to predict the charac teristic amplitude of shock fronts and the correspond ing peak pressures for a specific transducer or to develop transducers with specific parameters that ensure the desired shock wave field pressure levels.…”

Section: Introductionmentioning

confidence: 99%

Effect of the angular aperture of medical ultrasound transducers on the parameters of nonlinear ultrasound field with shocks at the focus

2015

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Certain modern applications of high intensity focused ultrasound (HIFU) in medicine use the nonlinear effect of shock front formation in the focal waveform. However, an important problem remains unsolved: determination of transducer parameters that provide the given pressure levels of the shock wave field at the focus required for a specific application. In this paper, simulations based on the KhokhlovZabolotskaya equation are performed to test and confirm the hypothesis that angular aperture of the trans ducer is the main parameter that determines the characteristic amplitude of the shock front and correspond ing values for the peak positive and negative pressures at the focus. A criterion for formation of a developed shock in the acoustic waveform, as well as a method for determining its amplitude is proposed. Quantitative dependences of the amplitude of the developed shock and the peak pressures in the wave profile on the angu lar aperture of the transducer are calculated. The effects of saturation and the range of changes of the shock waveform parameters at the focus are analyzed for a typical HIFU transducer.

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“…Therefore, it could be concluded that Cathepsin K has an important role in invasion and metastasis (Quintanilla-Dieck et al 2008). Progression of prostate tumour is facilitated in bone by Cathepsin K (Keller et al 2013). In case of colorectal carcinomas it is said that Cathepsin S plays novel roles in migration and invasion (Burden et al 2012).…”

Section: Cathepsinmentioning

confidence: 99%