A novel approach to the manufacture of dissolving microneedles arrays using aerosol jet printing

Ako, Hilkiah; O'Mahony, Joseph; Hughes, Helen; McLoughlin, Peter; O'Reilly, Niall J.

doi:10.1016/j.apmt.2023.101958

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…They have a smaller base and smaller diameter than the other ones, causing them to break at lower forces. However, these forces (200 and 400 N) are much higher than the forces employed during skin penetration. , …”

Section: Resultsmentioning

confidence: 94%

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Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Monou,

Andriotis,

Tzetzis

et al. 2024

ACS Appl. Bio Mater.

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In the current study, coated microneedle arrays were fabricated by means of digital light processing (DLP) printing. Three different shapes were designed, printed, and coated with PLGA particles containing two different actives. Rivastigmine (RIV) and N-acetyl-cysteine (NAC) were coformulated via electrohydrodynamic atomization (EHDA), and they were incorporated into the PLGA particles. The two actives are administered as a combined therapy for Alzheimer’s disease. The printed arrays were evaluated regarding their ability to penetrate skin and their mechanical properties. Optical microscopy and scanning electron microscopy (SEM) were employed to further characterize the microneedle structure. Confocal laser microscopy studies were conducted to construct 3D imaging of the coating and to simulate the diffusion of the particles through artificial skin samples. Permeation studies were performed to investigate the transport of the drugs across human skin ex vivo. Subsequently, a series of tape strippings were performed in an attempt to examine the deposition of the APIs on and within the skin. Light microscopy and histological studies revealed no drastic effects on the membrane integrity of the stratum corneum. Finally, the cytocompatibility of the microneedles and their precursors was evaluated by measuring cell viability (MTT assay and live/dead staining) and membrane damages followed by LDH release.

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Section: Resultsmentioning

confidence: 94%

“…However, these forces (200 and 400 N) are much higher than the forces employed during skin penetration. 58,59 Insertion Test. Insertion test was conducted for all the three MN arrays.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Monou,

Andriotis,

Tzetzis

et al. 2024

ACS Appl. Bio Mater.

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“…Mesin Jet Dyeing adalah mesin yang digunakan dalam industri tekstil untuk mewarnai bahan kain (Bevk et al, 2023;Perinka et al, 2013). Mesin ini unggul dalam hal efisiensi dan kapasitas produksi skala besar dengan HAPTIC (Ako et al, 2023;Schmidt et al, 2023). Kemampuan untuk menghasilkan warna yang merata pada bahan kain yang lebih tajam (Ja'fari et al, 2023;Lee et al, 2023).…”

Section: Pendahuluanunclassified

Perencanaan Penjadwalan Preventive Maintenance Mesin Jet Dyeing Menggunakan Pendekatan Critical Path Method di PT XXX

Astari,

Ihsan,

Hidayat

2023

jitter

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Jet Dyeing Machine is a machine used in the textile industry to dye fabric materials with efficiency and large-scale production capacity. PT XXX faces a high frequency of damage and total lost time on several components of production machines, so proper maintenance and maintenance in accordance with standards needs to be carried out to reduce the frequency of damage and total lost time and extend the service life of components. The CPM approach can help in creating an effective maintenance and maintenance schedule so that production can run smoothly and efficiently. This study aims to plan maintenance schedules and preventive maintenance on production machines at PT XXX using the CPM approach. The results of the analysis show that routine maintenance and maintenance of machine components is very important to reduce the frequency of damage and total lost time that can have an impact on production losses. The maintenance schedule must be considered carefully so as not to interfere with production and not to interfere with the performance of the machine and maintenance personnel must have adequate knowledge and skills to carry out maintenance and maintenance properly in accordance with the established SOP. Total losses due to wasted lost time can be reduced by 24% from the original. Repair and replacement of components that often experience damage need to be done to reduce the frequency of damage and total lost time on PT XXX production machines.

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“…With the advancement in manufacturing techniques [36][37][38][39], materials [40], and pre-/postprocessing methods [41], there has been a significant innovation in the MN field. Over the past decade, extensive research studies have been conducted on the fabrication of microneedles using various materials such as glass, ceramic, metal, and polymers [42][43][44][45]. Many of these traditional manufacturing methods have limitations such as being complex and labor-intensive, multiple manufacturing steps, limited design flexibility, and lack of cost-efficiency.…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

Aldawood,

Parupelli,

Andar

et al. 2024

Pharmaceutics

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Microneedle (MN) technology is an optimal choice for the delivery of drugs via the transdermal route, with a minimally invasive procedure. MN applications are varied from drug delivery, cosmetics, tissue engineering, vaccine delivery, and disease diagnostics. The MN is a biomedical device that offers many advantages including but not limited to a painless experience, being time-effective, and real-time sensing. This research implements additive manufacturing (AM) technology to fabricate MN arrays for advanced therapeutic applications. Stereolithography (SLA) was used to fabricate six MN designs with three aspect ratios. The MN array included conical-shaped 100 needles (10 × 10 needle) in each array. The microneedles were characterized using optical and scanning electron microscopy to evaluate the dimensional accuracy. Further, mechanical and insertion tests were performed to analyze the mechanical strength and skin penetration capabilities of the polymeric MN. MNs with higher aspect ratios had higher deformation characteristics suitable for penetration to deeper levels beyond the stratum corneum. MNs with both 0.3 mm and 0.4 mm base diameters displayed consistent force–displacement behavior during a skin-equivalent penetration test. This research establishes guidelines for fabricating polymeric MN for high-accuracy and low-cost 3D printing.

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A novel approach to the manufacture of dissolving microneedles arrays using aerosol jet printing

Cited by 6 publications

References 38 publications

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Perencanaan Penjadwalan Preventive Maintenance Mesin Jet Dyeing Menggunakan Pendekatan Critical Path Method di PT XXX

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

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