A novel approach on the preparation of biphasic calcium phosphate bioceramics under physiological conditions. The effect of the starting material

Aslanidou, Martha; Vaimakis, T.; Mitsionis, Anastasios; Trapalis, C.

doi:10.1016/j.ceramint.2012.06.060

Cited by 14 publications

(9 citation statements)

References 43 publications

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“…The parametric factors in the biomineralization processes of these materials have attracted the interest of biochemists, with a key issue being the case of hydroxyapatite (HAp, Ca 10 (PO 4 ) 6 (OH) 2 ) formation [21,22]. Many reports concern the transformation of DCPD to HAp [23][24][25][26][27][28]. Information on DCPD morphology is very useful for predicting in vivo bone and/or tooth bioactivity and for accelerating bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

Morphology control of brushite prepared by aqueous solution synthesis

Toshima

Hamai

Tafu

et al. 2014

Journal of Asian Ceramic Societies

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Dicalcium phosphate dihydrate (DCPD, CaHPO 4 •2H 2 O), also known as brushite, is one of the important bioceramics due to not only diseases factors such as kidney stone and plaque formation but also purpose as fluoride insolubilization material. It is used medicinally to supply calcium, and is of interest for its unique properties in biological and pathological mineralization. It is important to control the crystal morphology of brushite since its chemical reactivity depends strongly on its surface properties; thus, its morphology is a key issue for its applications as a functional material or precursor for other bioceramics. Here, we report the effects of the initial pH and the Ca and phosphate ion concentrations on the morphology of DCPD particles during aqueous solution synthesis. Crystal morphologies were analyzed by scanning electron microscopy and X-ray diffraction. The morphology phase diagram of DCPD crystallization revealed that increasing the initial pH and/or ion concentration transformed DCPD morphology from petal-like into plate-like structures.

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Section: Introductionmentioning

confidence: 99%

Morphology control of brushite prepared by aqueous solution synthesis

Toshima

Hamai

Tafu

et al. 2014

Journal of Asian Ceramic Societies

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“…Hybridization of calcium phosphates is one of the approaches for improvement of the property. Aslanidou et al [8] carried on the preparation of hybrid of HA/DCPD for controlling dissolution rate and mechanical properties. The present work was an investigation for the effect of hydroxyapatite (HA, Ca 10 (PO 4 ) 6 F 2 ) on the reaction of DCPD.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hydroxyapatite on Reaction of Dicalcium Phosphate Dihydrate DCPD) and Fluoride Ion

Tafu¹,

Masutani²,

Takemura³

et al. 2013

Bioceram Dev Appl

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DCPD, dicalcium phosphate dihydrate (CaHPO 4 •2H 2 O) reacts with fluoride ion in an aqueous solution, and forms fluorapatite (FAp, Ca 10 (PO 4 )6F 2 ). In previous study, we have found that DCPD does not react with fluoride ion directly, but show few hours of induction period by reaction with fluoride. In this study, effect of hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ) on the reactivity of DCPD with fluoride ion was investigated. By mixing HA with DCPD, it was appeared that the induction period of the reaction was shortened. Morphology of the obtained FAp was similar to HA paricles. We carried on coating of HA on the DCPD particle by soaking DCPD in simulated body fluid (SBF, Kokubo Solution). By coating HA on DCPD particles, particle morphology of the obtained FAp was consistency to the DCPD particles. These results suggest that the shape and particle size of FAp after reaction of DCPD is controllable by DCPD particle as template, and coating with HA. Effect of Hydroxyapatite on

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“…The most widely used calcium phosphate-based bioceramics are hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ) and βtricalcium phosphate (β-TCP, Ca 3 (PO 4 ) 2 ). [1][2][3][4][5] HA is commonly used as bioactive materials in bone graft, orthopaedic application, dental implant due to its excellent bonding ability to bone after implantation. [1] It is reported that the bonding ability with bone can be predicted via its ability of forming HA layer on the surface upon the immersion in simulated body fluid (SBF) solution, of which the ion concentrations are similar with human plasma.…”

Section: Introductionmentioning

confidence: 99%

“…[3] Thus, it is quite reasonable to expect that the advantage of biphasic calcium phosphate (BCP) such as: high bioactivity and its rapid biodegradation in a body fluid can be controllable by combining HA and β-TCP with proper ratio. [4][5] In this research, we aim to synthesize the BCP powder by the wet chemical precipitation method and evaluate the physicochemical properties of the synthetic material before and after in-vitro test in simulated body fluid.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of HA/β‐TCP bioceramic powder

Vương

2018

Vietnam Journal of Chemistry

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The main goal of this study is to elaborate and evaluate the physicochemical properties of the synthetic biphasic calcium phosphate (BCP) powder: a combined mixture of hydroxyapatite (HA): Ca10(PO4)6(OH)2 and beta‐tricalcium phosphate (β‐TCP): Ca3(PO4)2. The BCP mixture has two advantages: high bioactivity (HA) and rapid biodegradation (β‐TCP). The obtained powders of BCP were prepared by precipitate method. XRD analysisconfirmed that the synthetic materials were comprised of both HA and β‐TCP crystalline phases. SEM images showed that the small particles of HA attached on bigger particles of β‐TCP in the structure morphology of BCP. The in‐vitro experiment was carried out in static condition by soaking of a series of 50 mg BCP powders in 100 ml simulated body fluid (SBF) solution at different periods of soaking time. The microstructure and chemical bonds after soaking were studied by XRD and SEM methods. The obtained results confirmed the bioactivity of synthetic BCP material by the formation of a new apatite layer on its surface.

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A novel approach on the preparation of biphasic calcium phosphate bioceramics under physiological conditions. The effect of the starting material

Cited by 14 publications

References 43 publications

Morphology control of brushite prepared by aqueous solution synthesis

Morphology control of brushite prepared by aqueous solution synthesis

Effect of Hydroxyapatite on Reaction of Dicalcium Phosphate Dihydrate DCPD) and Fluoride Ion

Synthesis and characterization of HA/β‐TCP bioceramic powder

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