2011
DOI: 10.1186/1476-511x-10-67 View full text |Buy / Rent full text
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Abstract: BackgroundWS070117 is a novel small molecule compound that significantly improves lipid metabolism disorders in high-fat-diet (HFD) induced hyperlipidemia in hamsters.Methods and ResultsWe evaluated liver/body weight ratio, liver histology, serum and hepatic lipid content in HFD-fed hamsters treated with WS070117 for 8 weeks. Comparing with HFD fed hamsters, WS070117 (2 mg/kg per day and above) reduced serum triglyceride (TAG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and hepatic cho… Show more

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“…The tissue homogenate was then mixed with a solution of chloroform/methanol (2:1, v/v), according to a ratio of 1:1 (v/v). The prepared sample was centrifuged at 1200 x g for 10 minutes, and the obtained substratum was used for measurement of total cholesterol, triglyceride and free fatty acid according to the colorimetric methods (Lian et al, 2011).…”
Section: Determination Of Biochemical Indexesmentioning
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“…The tissue homogenate was then mixed with a solution of chloroform/methanol (2:1, v/v), according to a ratio of 1:1 (v/v). The prepared sample was centrifuged at 1200 x g for 10 minutes, and the obtained substratum was used for measurement of total cholesterol, triglyceride and free fatty acid according to the colorimetric methods (Lian et al, 2011).…”
Section: Determination Of Biochemical Indexesmentioning
“…Rat liver or skeletal muscle tissues (100 mg) were homogenized in 2 ml chloroform/methanol (2:1) for lipid extraction (Lian et al, 2011). Then the amounts of TC and TG were determined as described above.…”
Section: Estimation Of Malondialdehyde (Mda) Glutathione (Gsh) and Smentioning
“…Preliminary data suggest that liver Ppp2r2c may be that B subunit; this subunit is the only one expressed in mouse and human liver (Table 1). 3 Small molecule compounds that activate or inhibit AMP kinase have been generated (53)(54)(55)(56)(57). Preclinical trials suggest that they may be efficacious in treating diet-induced diabetes (56,58).…”
Section: Figure 11 Pp2amentioning