A non‐invasive method for the <i>in vivo</i> determination of skin antioxidant capacity (IAC‐S<sup>®</sup>)

Ziosi, Paola; Besco, Elena; Vertuani, Silvia; Solaroli, Nicola; Manfredini, Stefano

doi:10.1111/j.0909-752x.2006.00189.x

Cited by 11 publications

(16 citation statements)

References 8 publications

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“…Sweat and interstitial fluid are most often referred to as analytes . In addition, some studies have shown that the stratum corneum of the human skin is a biochemically active and informative object of research ; the prospects of using washings from the human skin as an analyte have been noted .…”

Section: Introductionmentioning

confidence: 99%

Optimized Potentiometric Assay for Non‐invasive Investigation of Skin Antioxidant Activity

2018

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The paper presents a new variant of non‐invasive potentiometric method for determination of human skin antioxidant activity (AOA). The use of a porous cellulose acetate membrane as the carrier for reagent solution (potassium hexacyanoferrate (III)) is presented. The increase of reagent shelf life, improvement the reproducibility of the results (during the day Sr≤0.08, interday Sr≤0.13) in comparison with previously described variant is demonstrated. It was shown that the components of the skin hydrolipid mantle and pH do not affect the potentiometric signal. The values of skin AOA determined by the developed method lie in the range 20–4000 μM‐eq. Recovery is Raverage=99 %. The skin of healthy people was studied by the developed method. The obtained results indicate the prospects of using a new non‐invasive approach in the study of the oxidation‐reduction balance of human skin.

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Section: Introductionmentioning

confidence: 99%

Optimized Potentiometric Assay for Non‐invasive Investigation of Skin Antioxidant Activity

2018

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“…Skin antioxidant network protects cells against oxidative injury and prevents the production of oxidation products. When oxidative stress overwhelms the skin antioxidant capacity, the subsequent modification of the cellular redox apparatus leads to an alteration of cell homeostasis leading to degenerative processes . In the dermo‐cosmetic field, the topical application of antioxidants is often suggested as a possible strategy to prevent and modulate oxidative skin damages.…”

Section: Methodsmentioning

confidence: 99%

“…IAC intrinsic property might be of particular interest in all the processes where it presents an overproduction of ROS/reactive nitrogen species such as inflammation to prevent and modulate oxidative skin damages and to reduce oxidative stress …”

Section: Methodsmentioning

confidence: 99%

“…When oxidative stress overwhelms the skin antioxidant capacity, the subsequent modification of the cellular redox apparatus leads to an alteration of cell homeostasis leading to degenerative processes. 65 In the dermo-cosmetic field, the topical application of antioxidants is often suggested as a possible strategy to prevent and modulate oxidative skin damages. The IAC (also named as IAC-Vita™) is a new nonpeptidyl low molecular weight radical scavenger able to give a fast reaction with the majority of radical species involved in the oxidative stress.…”

Section: Composition Rationalementioning

confidence: 99%

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A novel composition for in vitro and in vivo regeneration of skin and connective tissues

Gennero

Siena²,

Denysenko

et al. 2011

Cell Biochemistry & Function

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The particular combination of polydeoxyribonucleotides, l-carnitine, calcium ions, proteolytic enzyme and other ingredients acts in a synergetic way in the regeneration of skin and connective tissues. This new formulation of active principles was tested in vitro as a cell and tissue culture medium and in vivo for various preparations in support of tissue regeneration. In vitro, the new blend allowed the maintenance of skin biopsies for more than 1 year in eutrophic conditions. Immunocytochemical analyses of fibroblasts isolated from these biopsies confirmed a significant increase of the epidermal and connective wound-healing markers such as collagen type I, collagen type IV, cytokeratin 1 (CK1), CK5, CK10 and CK14 versus controls. To examine the effects of the new compound in vivo, we studied impaired wound healing in genetically diabetic db/db mice. At day 18, diabetic mice treated with the new composition showed 100% closure of wounds and faster healing than mice treated with the other solutions. This complex of vital continuity factors or life-keeping factors could be used as a tissue-preserving solution or a cosmetic/drug/medical device to accelerate wound healing in the treatment of patients with deficient wound repair to promote the regeneration of cutaneous and connective tissues (injuries-wound, dermatitis) and prevent the recurrent relapses.

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“…The skin is constantly exposed to chemical oxidants, air pollutants and ultraviolet (UV) solar light, which is the major generator for reactive oxygen species (ROS) that induct oxidative stress 24,25 . ROS are species of oxygen which are in a more reactive state than molecular oxygen, which can be reduced to varying degrees eg: superoxide (O 2 -), primary ROS, hydrogen peroxide, (H 2 O 2 ), produced by the further reduction of oxygen.…”

Section: I23 Physiological Parameters and Metabolites Concentratedmentioning

confidence: 99%

Vanishing tattoo multisensor for biomedical diagnostics

2008

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Currently, precise non-invasive diagnostics systems for the real-time multi detection and monitoring of physiological parameters and chemical analytes in the human body are urgently required by clinicians, physiologists and bio-medical researchers. We have developed a novel cost effective smart 'vanishing tattoo' (similar to temporary child's tattoos) consisting of environmental-sensitive dyes. Painlessly impregnated into the skin the smart tattoo is capable of generating optical/fluorescence changes (absorbance, transmission, reflectance, emission and/or luminescence within UV, VIS or NIR regions) in response to physical or chemical changes. These changes allow the identification of colour pattern changes similar to bar-code scanning. Such a system allows an easy, cheap and robust comprehensive detection of various parameters and analytes in a small volume of sample (e.g. variations in pH, temperature, ionic strength, solvent polarity, presence of redox species, surfactants, oxygen). These smart tattoos have possible applications in monitoring the progress of disease and transcutaneous drug delivery. The potential of this highly innovative diagnostic tool is wide and diverse and can impact on routine clinical diagnostics, general therapeutic management, skin care and cosmetic products testing as well as fundamental physiological investigations.

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A non‐invasive method for the in vivo determination of skin antioxidant capacity (IAC‐S^®)

Abstract: In view of the simplicity and reliability of the method here presented, this new technique is proposed as a possible tool for the routine evaluation of in vivo efficacy of antioxidant functional ingredients and finished products.

Cited by 11 publications

References 8 publications

Optimized Potentiometric Assay for Non‐invasive Investigation of Skin Antioxidant Activity

Optimized Potentiometric Assay for Non‐invasive Investigation of Skin Antioxidant Activity

A novel composition for in vitro and in vivo regeneration of skin and connective tissues

Vanishing tattoo multisensor for biomedical diagnostics

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A non‐invasive method for the in vivo determination of skin antioxidant capacity (IAC‐S®)

Abstract: In view of the simplicity and reliability of the method here presented, this new technique is proposed as a possible tool for the routine evaluation of in vivo efficacy of antioxidant functional ingredients and finished products.

Cited by 11 publications

References 8 publications

Optimized Potentiometric Assay for Non‐invasive Investigation of Skin Antioxidant Activity

Optimized Potentiometric Assay for Non‐invasive Investigation of Skin Antioxidant Activity

A novel composition for in vitro and in vivo regeneration of skin and connective tissues

Vanishing tattoo multisensor for biomedical diagnostics

Contact Info

Product

Resources

About

A non‐invasive method for the in vivo determination of skin antioxidant capacity (IAC‐S^®)