A non-invasive method for an in vivo assessment of corneal epithelium permeability through tetrapolar impedance measurements

Guimerà‐Brunet, Anton; Gabriel, Gemma; Plata-Cordero, María; Montero, Laura; Maldonado, Miguel J.; Villa, Rosa

doi:10.1016/j.bios.2011.09.039

Cited by 14 publications

(20 citation statements)

References 36 publications

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“…The chip was fabricated in the clean room facilities at the Barcelona Microelectronics Institute, Spain, through standard photolithography techniques [28][29][30]. Three different metal layers (titanium, nickel and gold) were deposited by sputtering over a 500 μm thick Pyrex wafer.…”

Section: Multi-parametric Sensormentioning

confidence: 99%

Simultaneous monitoring of Staphylococcus aureus growth in a multi-parametric microfluidic platform using microscopy and impedance spectroscopy

Estrada-Leypon

Moya

Guimerà‐Brunet

et al. 2015

Bioelectrochemistry

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Section: Multi-parametric Sensormentioning

confidence: 99%

Simultaneous monitoring of Staphylococcus aureus growth in a multi-parametric microfluidic platform using microscopy and impedance spectroscopy

Estrada-Leypon

Moya

Guimerà‐Brunet

et al. 2015

Bioelectrochemistry

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“…4,5 There have been several reports of similar devices in animal eyes, but to date, none in human eyes. [8][9][10][11][12][13][14] The purpose of this study was to determine whether our device can assess the CR value in healthy adult eyes.…”

mentioning

confidence: 99%

In Vivo Measurement of Human Corneal Impedance Value

Fukuda

Sekiya²

2016

Cornea

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“…Microsensors were created in clean room facilities at the Barcelona Microelectronics Institute (Spain), using standard photolithography techniques (Bonilla et al 2011;Gabriel et al 2007;Guimera et al 2012). To summarize, three metal layers were deposited by sputtering over a Pyrex wafer.…”

Section: Sensor Microfabricationmentioning

confidence: 99%

Biofilm dynamics characterization using a novel DO-MEA sensor: mass transport and biokinetics

Guimerà

Moya

Dorado

et al. 2014

Appl Microbiol Biotechnol

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Biodegradation process modeling is an essential tool for the optimization of biotechnologies related to gaseous pollutants treatment. In these technologies, the predominant role of biofilm, particularly under conditions of no mass transfer limitations, results in a need to determine what processes are occurring within the same. By measuring the interior of the biofilms, an increased knowledge of mass transport and biodegradation processes may be attained. This information is useful in order to develop more reliable models that take biofilm heterogeneity into account. In this study, a new methodology, based on a novel dissolved oxygen (DO) and mass transport microelectronic array (MEA) sensor, is presented in order to characterize a biofilm. Utilizing the MEA sensor, designed to obtain DO and diffusivity profiles with a single measurement, it was possible to obtain distributions of oxygen diffusivity and biokinetic parameters along a biofilm grown in a flat plate bioreactor (FPB). The results obtained for oxygen diffusivity, estimated from oxygenation profiles and direct measurements, revealed that changes in its distribution were reduced when increasing the liquid flow rate. It was also possible to observe the effect of biofilm heterogeneity through biokinetic parameters, estimated using the DO profiles. Biokinetic parameters, including maximum specific growth rate, the Monod half-saturation coefficient of oxygen and the maintenance coefficient for oxygen which showed a marked variation across the biofilm, suggest that a tool that considers the heterogeneity of biofilms is essential for the optimization of biotechnologies.2

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A non-invasive method for an in vivo assessment of corneal epithelium permeability through tetrapolar impedance measurements

Cited by 14 publications

References 36 publications

Simultaneous monitoring of Staphylococcus aureus growth in a multi-parametric microfluidic platform using microscopy and impedance spectroscopy

Simultaneous monitoring of Staphylococcus aureus growth in a multi-parametric microfluidic platform using microscopy and impedance spectroscopy

In Vivo Measurement of Human Corneal Impedance Value

Biofilm dynamics characterization using a novel DO-MEA sensor: mass transport and biokinetics

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