A new Web site compiling forensic chromosome X research is now online

Szibor, R.; Hering, Sandra; Edelmann, Jeanett

doi:10.1007/s00414-005-0029-y

Cited by 83 publications

(52 citation statements)

References 7 publications

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“…However, nationwide collaborations and the exchange of data between forensic genetics laboratories should overcome this problem. Since the amount of data regarding these topics may be very voluminous, basic research published in journals may be complemented online (http://www.chrx-str.org/) [18]. Furthermore, due to the strong LD, the use of haplotype population data as a reference may be problematic when no appropriate populations can be compared.…”

Section: Discussionmentioning

confidence: 99%

DXS10079, DXS10074 and DXS10075 are STRs located within a 280-kb region of Xq12 and provide stable haplotypes useful for complex kinship cases

et al. 2005

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The evaluation of the short tandem repeat (STR) markers DXS10079, DXS10074 and DXS10075 was amended to establish a STR cluster spanning a genetic distance<1 cM. These three STRs are located within a 280-kb region at Xq12 and provide stable haplotypes useful for solving complex kinship cases. Theoretically, this cluster could give rise to 2,548 different haplotypes in the German population and the genotyping of 781 men revealed the presence of 172 haplotypes. Since the three STRs were shown to be in strong linkage disequilibrium (LD), haplotype frequencies cannot be computed on the basis of a single locus allele frequency alone but have to be estimated directly. Here, we present data on linkage, haplotype frequencies and LD in a German population. Further clusters from other regions of the X chromosome will be published in the future to cover the chromosome with a well-structured network of highly informative sites.

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Section: Discussionmentioning

confidence: 99%

DXS10079, DXS10074 and DXS10075 are STRs located within a 280-kb region of Xq12 and provide stable haplotypes useful for complex kinship cases

et al. 2005

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“…org/) [27]. The mean exclusion chance of X-chromosomal markers in trios involving daughters (MEC TRIOS ) and father/daughter duos lacking the maternal genotype information (MEC DUOS ) were calculated according to Desmarais et al [28].…”

Section: Discussionmentioning

confidence: 99%

Potential forensic use of a 33 X-InDel panel in the Argentinean population

et al. 2016

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Polymorphic genetic markers located on the X chromosome might become a complement in particular forensic identification when the biological kinship are deficient. We analyzed forensic statistical parameters of 33 X-chromosome InDel polymorphisms in a sample of 320 individuals from Argentina. The X-chromosome InDel polymorphism (X-InDel) panel was amplified in a single multiplex PCR reaction. Hardy-Weinberg Equilibrium was determined in the female cohort, whereas the male cohort was used to calculate linkage disequilibrium (LD) tested by an extension of Fisher's exact test, D', and Chi-square values. Regarding LD, 15 markers were organized and grouped into six blocks containing two or three linked loci each, namely block I (MID356-MID357), block II (MID448804-MID3703-MID218), block III (MID3705-MID3706-MID304737), block IV (MID197147-MID3754), block V (MID3664-MID284601-MID103547), and block VI (MID3763-MID3728). The haplotype diversity was higher than 0.99 in all cases. Blocks III and VI showed the highest match probability in the studied population, whereas block II showed the lowest. The accumulated power of discrimination was 99.9999991 % in women and 99.9992925 % in men. The mean exclusion chance in trios and duos were 99.9891736 and 99.6099391 %, respectively. Since 15 markers are associated as haplotypic blocks, for a conservative treatment of the data, statistical evaluation should consider their haplotypic frequencies and the remaining 18 markers can be evaluated as independent loci.

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“…Allelic frequencies were calculated at each locus by PowerStatsV12 program (http://www.promega.com/ geneticidtools/). Mean exclusion chance in Duos (MEC D ), mean exclusion chance in trios (MEC T ), PD for females (PD F ), and PD in males (PD M ) were calculated by using chromosome X web software (http://www.chrx-str.org) [21].…”

Section: Methodsmentioning

confidence: 99%

Haplotype analysis of two X-chromosome STR clusters in the Pakistani population

2008

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Haplotype analysis of closely associated markers has proven to be a powerful tool in kinship analysis especially when X-chromosome short tandem repeats fail to resolve uncertainty in relationship analysis. Microsatellites located on the X chromosome show stronger linkage disequilibrium compared with autosomal microsatellites; hence, it is necessary to estimate the haplotype frequencies directly from population studies as linkage disequilibrium is population-specific. Here, we describe five markers residing in two clusters; cluster I harboring three STR markers DXS6801-DXS6809-DXS6789 and cluster II harboring two STR markers DXS7424-DXS101. A total of 302 male DNA samples of Pakistani descent were analyzed. Theoretically, 847 and 160 different combinations of haplotypes are possible in clusters I and II, but genotyping identified only 129 and 75 haplotypes, respectively. No evidence of linkage disequilibrium was detected, except for the pair (DXS6801-DXS6789), consistent with results obtained with the cluster I in a German population. Our results demonstrate that 83% haplotypes of cluster I and 65% haplotypes of cluster II show <1% frequency in the Pakistani population. This strongly suggests that haplotypes of these two clusters provide a powerful tool for kinship testing and relationship investigations.

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A new Web site compiling forensic chromosome X research is now online

Cited by 83 publications

References 7 publications

DXS10079, DXS10074 and DXS10075 are STRs located within a 280-kb region of Xq12 and provide stable haplotypes useful for complex kinship cases

DXS10079, DXS10074 and DXS10075 are STRs located within a 280-kb region of Xq12 and provide stable haplotypes useful for complex kinship cases

Potential forensic use of a 33 X-InDel panel in the Argentinean population

Haplotype analysis of two X-chromosome STR clusters in the Pakistani population

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