A new verbal reports fMRI dichotic listening paradigm for studies of hemispheric asymmetry

Noort, Maurits van den; Specht, Karsten; Rimol, Lars M.; Ersland, Lars; Hugdahl, Kenneth

doi:10.1016/j.neuroimage.2007.11.051

Cited by 80 publications

(61 citation statements)

References 47 publications

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“…This is clearly a finding much in keeping with previous reports of neuroimaging of dichotic listening (e.g., van den Noort, 2008). The activation observed in the right-hemispheric counterpart of Wernicke"s area in the temporal lobe strengthens the hypothesis of Grodzinsky and Friederici (2006), who linked this area to lexical and syntactic information integration.…”

Section: Discussionsupporting

confidence: 90%

“…Although the latter point rarely has been examined in patients with brain damage, it is still important to know how fMRI results and behavioral measures relate to each other. According to our findings, the directed-report-left condition of the Bergen Dichotic Listening Test indicated lateralization with respect to the posterior temporal lobe, which is likely to be the cortical region of choice when assessment of language lateralization is warranted (Van den Noort et al, 2008).…”

Section: Discussionmentioning

confidence: 61%

“…With fMRI, the hemispheric asymmetry of the activation pattern reflects lateralization of language. The fMRI-determined lateralization index (LI) has been shown to correlate with some versions of dichotic listening (Fernandes et al, 2006;Fontoura et al, 2008; Van den Noort et al, 2008). More convincingly, both dichotic listening (Strauss et al, 1987;Hugdahl et al, 1997;Fontoura et al, 2008) and fMRI-LI tests (Desmond et al, 1995;Yetkin et al, 1995;Spreer et al, 2002, Fontoura et al, 2008 repeatedly show a correlation with Wada test results.…”

Section: Introductionmentioning

confidence: 97%

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Right-hemispheric brain activation correlates to language performance

et al. 2010

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Language function in the right-hemispheric homologues of Broca"s and Wernicke"s areas does not only correlate with left-handedness or pathology, but occurs naturally in righthanded healthy subjects as well. In the current study, two non-invasive methods of assessing language lateralization are correlated with behavioral results in order to link hemispheric dominance to language ability in healthy subjects.Functional Magnetic Resonance Imaging (fMRI) together with a sentence-completion paradigm was used to determine region-specific lateralization indices in the left-and rightsided Broca"s and Wernicke"s areas, the frontal temporal lobe, the anterior cingulate cortex and the parietal lobe. In addition, dichotic listening results were used to determine overall language lateralization and to strengthen conclusions by correlating with fMRI indices.Results showed that fMRI lateralization in the superior parietal, the posterior temporal, and the anterior cingulate cortices correlated to dichotic listening. A decreased right ear advantage (REA), which indicates less left-hemispheric dominance in language, correlated with higher performance in most administered language tasks, including reading, language ability, fluency, and non-word discrimination. Furthermore, right hemispheric involvement in the posterior temporal lobe and the homologue of Broca"s area suggests better performance in behavioral language tasks. This strongly indicates a supportive role of the right-hemispheric counterparts of Broca"s and Wernicke"s areas in language performance.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 97%

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Right-hemispheric brain activation correlates to language performance

et al. 2010

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“…This procedure created a stochastic event-related design for fMRI acquisition (30), which was recorded in a single session. The dichotic CV syllables were presented by using headphones (NordicNeuroLab) at the beginning of the silent gaps of the sparse sampling protocol for the fMRI acquisition (31). The participants responded orally by naming the syllable they heard immediately after the stimulus, thereby ensuring response termination by the start of the next scan and avoiding movement artifacts during data acquisition.…”

Section: Methodsmentioning

confidence: 99%

Resting-state glutamate level in the anterior cingulate predicts blood-oxygen level-dependent response to cognitive control

Falkenberg

Westerhausen

Specht

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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The dorsal anterior cingulate cortex (dACC) is a core structure for the governing of cognitive control, and recent studies have shown that interindividual differences in dACC anatomy are associated with corresponding differences in the ability for cognitive control. However, individuals differ not only in anatomical features of dACC, but also exhibit substantial variability regarding the biochemical characteristics of the dACC. In this study, we combined magnetic resonance spectroscopy ( 1 H-MRS) and functional magnetic resonance imaging (fMRI), finding that interindividual differences of glutamate levels in the dACC during resting-state predict the strength of the blood-oxygen level-dependent (BOLD) response to a task requiring cognitive control. This relationship was observed in the retrosplenial cortex, the orbitofrontal cortex, the inferior parietal lobe, and the basal ganglia. More specifically, individuals with low resting-state glutamate levels in the dACC showed an increased BOLD response when the task demands were high, whereas high-glutamate individuals showed the opposite pattern of an increased BOLD response when the task demands were low. Thus, we show here that individual variability of glutamate levels is directly related to how the brain implements cognitive control.dichotic listening | default-mode network | gamma-aminobutyric acid D espite the steadily increasing knowledge concerning the neuronal underpinnings of cognitive control processes, little is known regarding the underlying biochemistry. Glutamate is particularly interesting in this respect because it is the most important excitatory neurotransmitter in the brain and also acts as a substantial intermediate in cerebral energy metabolism (1). Glutamate functioning is known to be reduced in several psychiatric disorders associated with an impairment in cognitive control (2), and pharmacologically induced reduction of glutamate levels has been found to alter the blood-oxygen level-dependent (BOLD) response to cognitively demanding tasks (3, 4). Here, we investigate the effect of interindividual variations in levels of glutamate on cognitive control mechanisms in healthy subjects. As target region for this investigation, the dorsal anterior cingulate cortex (dACC) was chosen because it represents a core region for handling cognitive conflict (5) and regulating the engagement of cognitive control processes (6), in addition to having strong connections to the frontoparietal and frontostriatal executive and cognitive control networks (7-9). Furthermore, the dACC is rich in glutamatergic innervation (10), rendering it as the prime candidate for the investigation of how individual glutamate levels affect the neuronal implementation of cognitive control.Individual levels of glutamate were determined in a resting state (rsGlu) in 40 healthy adults, using proton magnetic resonance spectroscopy ( 1 H-MRS) from bilateral voxels located in the dACC (Fig. 1A). The auditory cognitive control paradigm for the functional MRI (fMRI) acquisition has been fre...

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“…Then, all participants completed the Edinburgh Handedness Inventory [44], Hoen and Yahr stage [42], and were reminded of the specific task instructions of the fMRI experiment. They were instructed not to move their bodies and heads [49]. A block design was used.…”

Section: Experimental Design and Proceduresmentioning

confidence: 99%

A Case Report of Drug-Induced Parkinsonism Treated with Jodeung-san and Electro-acupuncture at GB34

Kim¹,

Song²,

Kim³

et al. 2017

J Int Korean Med

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Background: Acupuncture is increasingly used as an additional treatment for patients with Parkinson's disease (PD). Methods: In this functional magnetic resonance imaging study, brain activation in response to acupuncture in a group of 12 patients with PD was compared with a group of 12 healthy participants. Acupuncture was conducted on a specific acupoint, the right GB 34 (Yanglingquan), which is a frequently used acupoint for motor function treatment in the oriental medical field.Results: Acupuncture stimulation on this acupoint activates the prefrontal cortex, precentral gyrus, and putamen in patients with PD; areas that are known to be impaired in patients with PD. Compared with healthy participants, patients with PD showed significantly higher brain activity in the prefrontal cortex and precentral gyrus, especially visible in the left hemisphere. Conclusions:The neuroimaging results of our study suggest that in future acupuncture research; the prefrontal cortex as well as the precentral gyrus should be treated for symptoms of Parkinson's disease and that GB 34 seems to be a suitable acupoint. Moreover, acupuncture evoked different brain activations in patients with Parkinson's disease than in healthy participants in our study, stressing the importance of conducting acupuncture studies on both healthy participants as well as patients within the same study, in order to detect acupuncture efficacy.Trial registration: KCT0001122 at cris.nih.go.kr (registration date: 20140530)

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A new verbal reports fMRI dichotic listening paradigm for studies of hemispheric asymmetry

Cited by 80 publications

References 47 publications

Right-hemispheric brain activation correlates to language performance

Right-hemispheric brain activation correlates to language performance

Resting-state glutamate level in the anterior cingulate predicts blood-oxygen level-dependent response to cognitive control

A Case Report of Drug-Induced Parkinsonism Treated with Jodeung-san and Electro-acupuncture at GB34

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