A new trend in the medication of hepatocyte cytoxicity in mice: protective role of probiotic bacteria

Allam, Nanis G.; El‐Sheekh, Mostafa M.; Sarhan, Naglaa I.; Alfakharany, Ghada S

doi:10.1007/s11356-020-10420-z

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…Lactobacillus plantarum (LP) C88 can prevent liver injury in mice induced by aflatoxin B1 (AB1). Compared to the AB1 group, the LP‐C88 group downregulates the mRNA expressions of interleukin‐1 (IL‐1), IL‐6, and tumor necrosis factor‐α (TNF‐α) by about 50%, 33% ,and 44%, respectively (Huang et al., 2019), and LP‐DSMZ 2017 showed antioxidant effects by decreasing CCl 4 ‐induced liver lipid peroxidation (LPO) and scavenging 2,2‐diphenyl‐1‐picryl‐hydrazyl (DPPH) levels and increasing serum liver enzyme activity in mice (Allam et al., 2021). The protective function of lactic acid bacteria as a functional food on the liver has been confirmed.…”

Section: Introductionmentioning

confidence: 99%

Preventive effect of Lactobacillus plantarum HFY15 on carbon tetrachloride (CCl₄)‐induced acute liver injury in mice

Long

Wang

Zhou

et al. 2022

Journal of Food Science

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Carbon tetrachloride (CCl 4 ) is the main chemical causing liver damage. In this experiment, the effect of Lactobacillus plantarum HFY15 treatment on CCl 4 -induced acute liver injury was investigated using mice. Fifty adult mice were randomized into five study groups, each group with 10 ml kg -1 saline, 50 mg kg -1 silymarin, and 10 9 CFU kg -1 L. plantarum HFY15 and LDSB per day, and all the mice expect the normal group were injected 0.8% CCl 4 (10 ml kg -1 ) on the 14th day. Following the 16 h induction of the liver injury, various biochemical markers were assessed for blood and liver tissue. After L. plantarum HFY15 treatment, the content of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglycerides (TG), malondialdehyde (MDA), and reactive oxygen species (ROS) in serum decreased by 67.7%, 65.0%, 41.9%, 59.5%, and 51.5%, respectively, and the level of antioxidant enzymes (total superoxide dismutation [T-SOD], catalase [CAT], glutathione [GSH]) increased by more than twofold. Pro-inflammatory cytokine interleukin-6 (IL-6), interferon-γ (INF-γ), and tumor necrosis factorα (TNF-α) decreased by more than 45% in serum and live. What is more, L. plantarum HFY15 increased the expression of antiapoptosis genes Bcl-2 by eightfold, inhibiting the expression of proapoptotic genes Caspase-3 and Bax by about threefold. Lactobacillus plantarum HFY15 has obvious protective effects on CCl 4induced liver injury by inhibiting oxidation, reducing the release of inflammatory factors, and exerting suppressive effect on apoptotic process in the CCl 4 -induced liver injury. Lactobacillus plantarum HFY15 can be developed as edible lactic acid bacteria for preventing liver toxicity.

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Section: Introductionmentioning

confidence: 99%

Preventive effect of Lactobacillus plantarum HFY15 on carbon tetrachloride (CCl₄)‐induced acute liver injury in mice

Long

Wang

Zhou

et al. 2022

Journal of Food Science

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“…Lactic acid bacteria is a microbial species widely used as probiotics in the food industry. It has been proven to have multiple functions such as regulating skin health [7], reducing memory impairment in mice [8], and inhibiting enterovirus Coxsackie virus B4 (CV-B4) [9], Other studies have shown that Lactobacillus fermentum LA12 can be used to prevent and treat alcoholic liver injury [10]; Lactobacillus plantarum (LP) C88 can prevent liver injury in mice induced by a atoxin B1 [11]; and LP-DSMZ 2017 protects the liver through antioxidant effects [12]. The protective function of lactic acid bacteria as a functional food on the liver has been con rmed.…”

Section: Introductionmentioning

confidence: 99%

Preventive Effect of Lactobacillus Plantarum HFY15 on Oxidative Damage and Acute Liver Injury Induced by Carbon Tetrachloride (CCl 4 ) in Mice

Long

Wang

Zhou

et al. 2021

Preprint

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BackgroundCarbon tetrachloride (CCl4) is a widely used hepatic toxin that causes acute liver injury through pathological mechanisms such as oxidative stress, inflammation, and apoptosis. In this experiment, mice were treated with Lactobacillus plantarum (LP) HFY15, silymarin, and Lactobacillus delbruechii subsp. bulgaricus (LDSB) for two weeks, and intraperitoneal injection of CCl4-induced acute liver injury to study the preventive effect of LP-HFY on CCl4-induced acute liver injury, especially in oxidative damage. ResultsThe survival rate of LP-HFY15 in artificial gastric juice is 92.1%, and the growth efficiency in bile salt is 78.8%. Animal experiments show that LP-HFY15 reduces the liver index of mice, reduces the activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the content of triglycerides (TG), malondialdehyde (MDA) and reactive oxygen species (ROS) in the serum of mice. LP-HFY15 also increased the antioxidant genes, such as nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase (HO-1), NAD(P)H:quinone oxidoreductase (NQO1), and increases the activity of superoxide dismutation (SOD), catalase (CAT), and glutathione (GSH) in the serum and gene level. At the same time, LP-HFY15 reduced the levels of cytokines IL-6, TNF-α, and IFN-γ in the serum and liver, increased antiapoptosis gene B-cell lymphoma-2 (Bcl-2) expression in the liver of mice, and inhibit the expression of proapoptotic genes Bcl-2-associated X (Bax) and Caspase-3. ConclusionsCompared with LDSB, LP-HFY15 has a greater alleviating effect on the liver injury caused by CCl4. These findings demonstrate that LP-HFY15 has great potential and research value in the future as a food supplement for preventing acute liver damage.

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Antioxidant and Antiradical Properties of Probiotic Strains Bacillus amyloliquefaciens ssp. plantarum

Safronova

Skorochod

Ilyash

2021

Probiotics & Antimicro. Prot.

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A new trend in the medication of hepatocyte cytoxicity in mice: protective role of probiotic bacteria

Cited by 5 publications

References 33 publications

Preventive effect of Lactobacillus plantarum HFY15 on carbon tetrachloride (CCl₄)‐induced acute liver injury in mice

Preventive effect of Lactobacillus plantarum HFY15 on carbon tetrachloride (CCl₄)‐induced acute liver injury in mice

Preventive Effect of Lactobacillus Plantarum HFY15 on Oxidative Damage and Acute Liver Injury Induced by Carbon Tetrachloride (CCl 4 ) in Mice

Antioxidant and Antiradical Properties of Probiotic Strains Bacillus amyloliquefaciens ssp. plantarum

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A new trend in the medication of hepatocyte cytoxicity in mice: protective role of probiotic bacteria

Cited by 5 publications

References 33 publications

Preventive effect of Lactobacillus plantarum HFY15 on carbon tetrachloride (CCl4)‐induced acute liver injury in mice

Preventive effect of Lactobacillus plantarum HFY15 on carbon tetrachloride (CCl4)‐induced acute liver injury in mice

Preventive Effect of Lactobacillus Plantarum HFY15 on Oxidative Damage and Acute Liver Injury Induced by Carbon Tetrachloride (CCl 4 ) in Mice

Antioxidant and Antiradical Properties of Probiotic Strains Bacillus amyloliquefaciens ssp. plantarum

Contact Info

Product

Resources

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Preventive effect of Lactobacillus plantarum HFY15 on carbon tetrachloride (CCl₄)‐induced acute liver injury in mice

Preventive effect of Lactobacillus plantarum HFY15 on carbon tetrachloride (CCl₄)‐induced acute liver injury in mice