A new technique of autogenous conduits for bridging short nerve defects. An experimental study in the rabbit

Abstract

An epineurial flap can be used to bridge a nerve defect with success.

Posttraumatic neuroma of the radial nerve treated with an autogenous epineural conduit technique. A case report

“…Several experimental studies in animals supported the idea of using the epineurium in nerve reconstructive surgery. [8][9][10][11][12][13] The epineurium tube protects the regeneration site from undesirable external humoral influences providing a positive regeneration environment. The interposed epineurium is not just a passive conduit but it may assume a more active role in the nerve regeneration process by providing neurotrophic factors.…”

“…The epineurium is a biologically active membrane surrounding the nerve and contributes significantly to its function. It has been used in animals [8][9][10][11][12][13] to bridge nerve defects.…”

“…We describe the first clinical application of an epineural flap technique, experimentally validated in rabbits, 8,9 in a patient with short radial nerve defect after excision of a neuroma-in-continuity.…”

The mesenchymal stem cell–derived microvesicles enhance sciatic nerve regeneration in rat

“…1 Autologous nerve graft is widely accepted as the most effective procedure for repairing a neural gap; however, the availability of donor nerves and donor site morbidity are major concerns. 2 Therefore, numerous surgical methods such as bioabsorbable or nonbioabsorbable conduits are being used for bridging nerve defects. 3Y5 It has been approved that cellular elements are needed to provide the neurotropic and neurotrophic support for axonal regrowth.…”

Emergency management of traumatic collateral palmar digital nerve defect inferior to 30mm by venous grafting. Report on 12 clinical cases

“…Synthetic grafts do not necessitate to be harvested but they are significantly expensive. Other tubulization methods remain under experimentation (pseudo-synovial tubes [2], perineural tubes [2], epineural flaps [17]). …”