A new stable pluronic® F68 gel carrier for antibiotics in contaminated wound treatment

Development of an insect metalloproteinase inhibitor drug carrier system for application in chronic wound infections

“…The formulation for IMPI has to be suitable for use in chronic wound infections. It has to provide a moisturising environment, adequate gaseous exchange and protection against new infections [9,10]. Moreover, it should be biocompatible and able to be applied easily and painlessly, as well as free from toxic contaminants and antigens [9,11].…”

“…Poloxamer 407 (P407) is particularly well established as a material that increases in viscosity in response to a thermal stimulus, and it is approved by the FDA as a pharmaceutical ingredient and listed in the US and European Pharmacopoeia [21,22]. This triblock copolymer with the central hydrophobic chain of polyoxy‐propylene (PPO) flanked by two identical lateral hydrophilic polyoxy‐ethylene (PEO) blocks is relatively inert, nontoxic and nonimmunogenic [10,14,15,23]. In aqueous solution, P407 is surrounded by a hydration layer.…”

Bioavailability Effect of Methylprednisolone by Polymeric Micelles

“…The small nano size of these PM may also ease further penetration of micellar carrier through BBB into the CNS system (20,29), and increase the transport of drug across membrane of BBB by membrane perturbance (20,26). The lower toxicity and non-immunogenic properties of PM carrier have been also proved by the Food and Drug administration (30). Other advantages related to the nanoscopic dimensions of this PM include the ease of sterilization via filtration and safety of administration.…”

A Prospective Randomized Trial Comparing Silver Sulfadiazine Cream With a Water-Soluble Polyantimicrobial Gel in Partial-Thickness Burn Wounds

“…Quantitative cultures yielded resistant bacteria despite treatment with many topical agents including SSD. In response, our team developed an alternate topical therapy consisting of a surfactant-based gel and culture-directed broad spectrum additives, termed UVA Burn Wound Gel ( Faulkner et al, 1997 ). The surfactant carrier has been widely studied and found to be nontoxic to human cells ( Rodeheaver, Kurtz, Kircher, & Edlich, 1980 ).…”