A New Spiropyran-Based Fluorescent Probe for Dual Sensing of Ferrous Ion and pH

NIR squaraine dyes for dual colorimetric and fluorescent determination of Fe3+, Cu2+, and Hg2+ ions

“…The interference experiments demonstrated the good selective recognition of BBSQ to Fe 3+ , Cu 2+ , and Hg 2+ even in the presence of other metal ions. 1,5…”

“…[2][3][4] Iron is involved in oxygen transport and proton transfer in blood and is an important component of various enzymes and hemoglobin. 5 The lack of iron in the body will lead to physiological dysfunction, thereby causing diseases. Excess iron is also potentially harmful, becoming toxic by promoting the oxidation of fats, proteins, and other components of the cell.…”

“…8 Colorimetric and uorescence detection technology realizes the visual detection of metal ions, simplies the analysis operation, and improves the detection sensitivity, which plays an important role in promoting the research and solution of problems that plague the origin of human life, disease diagnosis, and treatment, as well as environmental pollution and food safety issues. 5,12 There are a large number of colorimetric and uorescent metal ion probes with various organic molecular platforms, including boron-dipyrromethene (BODIPY), rhodamine, uorescein, coumarin, and naphthimide (shown in Table S1 †), whose absorption and uorescence emission wavelength are usually in the ultraviolet and visible (UV-vis) regions. 13,14 In order to expand the application of the metal ion probes in biological systems, chromophores and uorophores such as cyanines, and squaraines (SQs) with near-infrared (NIR) absorption and uorescence emission properties have attracted more and more attention.…”

Recent Progress in Fluorescent Probes For Metal Ion Detection

“…For Fe 2+ detection, Yang et al ( Yang et al, 2021 ) reported on the aggregation-induced emission (AIE) based probe named QM-Fe, and verified the feasibility of Fe 2+ detection in viable cells. Zhang et al ( Zhang D. et al, 2021 ) gained a new spiropyran-based fluorescent probe to detect Fe 2+ ion. The results show that the addition of Fe 2+ with the probe solution improved the magnetic intensity of fluorescence by 6-fold.…”

Spiropyran–Merocyanine Based Photochromic Fluorescent Probes: Design, Synthesis, and Applications

“…In 2021, Cong’s group 38 reported a spiropyran fluorescent probe 8 , which was synthesized by a two-step reaction (in the first step N-alkylation of 2,3,3-trimethyl-3 H -indole with benzyl bromide was done, and in the second step a condensation reaction was done with the intermediate N -benzyl-2,3,3-trimethyl-3 H -indolium bromide and 5-chlorosalicylaldehyde) for dual recognition of Fe 2+ and pH. Probe 8 in 9:1 EtOH/H 2 O exhibited weak fluorescence, but in the presence of Fe 2+ , a 6-fold enhancement in fluorescence intensity at 360 nm was found.…”