A new set‐up of vanishing antibodies: A biennial follow‐up of five different clients' humoral responses against SARS‐CoV‐2 after systemic vaccination in an oncology hospital in Poland

Abstract

The common severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has infected approximately 600 million people across 228 countries worldwide, leaving behind natural immunity. 1 Acute COVID-19 infection can cause a cytokine storm that leads to acute respiratory failure (ARDS) and death, 2 while severe inflammatory disease can result in chronic polymyositis syndrome in children (PIMS). 3 Almost half (44.8%) of symptomatic infections in children and adults manifest as varied symptoms related to chronic infection, in the form of long-COVID/post-COVID clinical syndrome, cognitive and physical deficits, pulmonary fibrosis, myocarditis, or neurological deficits. 4,5 The findings so far show that to acquire antiviral immunity to SARS-CoV-2, one does not need to come into contact with the virus and become infected. 6 Being around immunized people can provide a cellular and humoral response. To what extent is it active and provides self-immunity? How to check if we have acquired the appropriate antivirus response, or only had contact with it? When should a booster be given?The situation applies to everyone, including the healthy, those sick with a viral disease in any stage, those with impaired immunity,

COVID-19–Sensitive Tumour Response – 2-Year Assessment of the SARS-CoV-2 Humoral Response in Cancer Patients in Oncology Hospital in Poland

“…The results contained in our previous work, which assessed the post-vaccination response to BNT162b2 (Pfizer: Comirnaty) and the reaction after COVID-19, based on a 2-year analysis of 5 cases of differentiated humoral response, showed surprising conclusions [14]. In the summary of the work, administering at least three doses of mRNA vaccine should serve as the basis for immunization, and a three-month interval may be the best alternative to the vaccination schedule for nonimmunocompromised (healthy) people.…”