2008
DOI: 10.1099/jmm.0.2008/000505-0
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Abstract: The penicillin-resistant Spain 9V -3 clone of Streptococcus pneumoniae is widespread and presents different serotype variants originating from recombination of the capsular genes. In this work, the genetic relatedness of 29 invasive pneumococci isolated from the central region of Argentina (Cordoba, Buenos Aires, Santa Fe and La Pampa provinces) was assessed by multilocus sequence typing (MLST). All of the penicillin-non-susceptible isolates studied (21/29) belonged to a serotype 14 variant of the Spain 9V -3 … Show more

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Cited by 12 publications
(14 citation statements)
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References 23 publications
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“…We also demonstrated that this that this compensatory mechanism was present in the clinical strains that belonged to the new serotype-14 variant of the Spain 9V -3 pneumococcal clone identified in Argentina [13]. Related to this, several other studies have reported that the fitness cost associated to antibiotic resistant mutants depends on the specific mutations related to the resistant mechanism and the genetic background [5], [24], [25], [26], [27], [28].…”
Section: Discussionsupporting
confidence: 66%
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“…We also demonstrated that this that this compensatory mechanism was present in the clinical strains that belonged to the new serotype-14 variant of the Spain 9V -3 pneumococcal clone identified in Argentina [13]. Related to this, several other studies have reported that the fitness cost associated to antibiotic resistant mutants depends on the specific mutations related to the resistant mechanism and the genetic background [5], [24], [25], [26], [27], [28].…”
Section: Discussionsupporting
confidence: 66%
“…As mentioned above, fitness restoration has not been reported for pbp mutations obtained from clinical strains that belong to the Spain 6B -2, Hungary 19A -6, and serotype-9V Spain 9V -3 international clones [12]. Nevertheless, we demonstrated that a compensatory mechanism was present, at least in the new serotype-14 variant of the Spain 9V -3 clone recently characterized in our laboratory [13], and also in a serotype-9V reference strain of this clone (ATCC 700671) isolated in France [36]. Therefore, this model contributes to the understanding of βL resistance evolution in S. pneumoniae .…”
Section: Discussionsupporting
confidence: 46%
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“…Spain 9V -3 is probably the clone responsible for the spread of resistance to penicillin in our municipality, as observed in other places of Latin America. 45 …”
Section: Discussionmentioning
confidence: 99%