A new quantitative index in the diagnosis of Parkinson syndrome by dopamine transporter single-photon emission computed tomography

Bando, Ryota; Otsuka, Hideki; Otani, Tamaki; Matsuda, Noritake; Azane, Shota; Kunikane, Yamato; Otomi, Yoichi; Sako, Wataru; Izumi, Yuishin; Harada, Masafumi

doi:10.1007/s12149-021-01592-w

Cited by 4 publications

(6 citation statements)

References 22 publications

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“…As such, the SBR represents a relative quantification of DaTSCAN activity [21,32]. Standardized uptake value (SUV) is another quantitative index clinically used in PET and, more recently, in SPECT-CT [33].…”

Section: Discussionmentioning

confidence: 99%

“…Standardized uptake value (SUV) is another quantitative index clinically used in PET and, more recently, in SPECT-CT [33]. Previous studies have tried using SUVs to measure DaTSCAN uptake [21,22]; however, Toriihara et al concluded that SBR values are preferable over SUVs when trying to distinguish between neurodegenerative Parkinsonian syndromes and SWEDD [22]. This could be explained by SUVs being normalized to body weight despite previous publications showing no correlation between body habitus and uptake in the brain [2,34,35]; therefore, we decided to calculate the uptake by normalizing concentration to the administered activity to create the normalized concentrations and NSU quantitative indices.…”

Section: Discussionmentioning

confidence: 99%

“…These lead to an overestimation of the striatum-to-background ratios. As such, the SBR represents a relative quantification of DaTSCAN activity [21,32].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Therefore, an absolute, rather than relative, measure of the radioactivity in different regions of the brain is necessary [20]. This can be achieved by replacing the clinically used SPECT with SPECT-computed tomography (SPECT-CT), allowing the fusion of anatomical and functional information and positively impacting image interpretation and diagnostic accuracy [21]. Furthermore, when combined with a suitable calibration factor, this enables the absolute quantification of activity within a given volume, which can then be compared with the administered activity to calculate the uptake.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative [123]I-Ioflupane DaTSCAN single-photon computed tomography-computed tomography in Parkinsonism

Missir

Begley

Jessop

et al. 2023

Nuclear Medicine Communications

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Aim [123]I-Ioflupane (DaTSCAN) binds to the presynaptic dopamine transporter (DAT) and with a lower affinity to the serotonin transporter (SERT). We aimed to develop a novel method to quantify absolute uptake in the striatal (predominantly DAT binding) and extra-striatal regions (mainly SERT binding) using single-photon computed tomography-computed tomography (SPECT-CT) DaTSCAN and to improve DaTSCAN image quality. Method Twenty-six patients with Parkinsonism underwent DaTSCAN SPECT-CT prospectively. The scans were visually analyzed independently by two experienced reporters. Specific binding ratios (SBRs) from Chang attenuation corrected SPECT were obtained using GE DaTQuant. Normalized concentrations and specific uptakes (NSU) from measured attenuation and modelled scatter-corrected SPECT-CT were obtained using HERMES Hybrid Recon and Affinity and modified EARL volumes of interest. Results Striatal NSU and SBR positively correlate (R = 0.65–0.88, P = 0.00). SBR, normalized concentrations, and NSU box plots differentiated between scans without evidence of dopaminergic deficit and abnormal scans. Interestingly, body weight inversely correlated with normalized concentrations values in extra-striatal regions [frontal (R = 0.81, P = 0.00); thalamus (R = 0.58, P = 0.00); occipital (R = 0.69, P = 0.00)] and both caudate nuclei [R = 0.42, P = 0.03 (Right), R = 0.52, P = 0.01 (Left)]. Both reporters noted improved visual quality of SPECT-CT versus SPECT images for all scans. Conclusion DaTSCAN SPECT-CT resulted in more accurate quantification, improved image quality, and enabled absolute quantification of extra-striatal regions. More extensive studies are required to establish the full value of absolute quantification for diagnosis and monitoring the progression of neurodegenerative disease, to assess an interplay between DAT and SERT, and to verify serotonin and DATs are potentially DATs are dysfunctional in obesity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…These lead to an overestimation of the striatum-to-background ratios. As such, the SBR represents a relative quantification of DaTSCAN activity [21,32].…”

Section: Discussionmentioning

confidence: 99%