A New Potential Resource in the Fight against Candida auris: the
            <i>Cinnamomum zeylanicum</i>
            Essential Oil in Synergy with Antifungal Drug

Vito, Maura Di; Garzoli, Stefania; Rosato, Roberto R.; Mariotti, Melinda; Gervasoni, Jacopo; Santucci, Lavinia; Ovidi, Elisa; Cacaci, Margherita; Lombarini, G; Torelli, Riccardo; Urbani, Andrea; Sanguinetti, Maurizio; Bugli, Francesca

doi:10.1128/spectrum.04385-22

Cited by 11 publications

(7 citation statements)

References 42 publications

(54 reference statements)

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“…The MFC values obtained with EO are comparable to those obtained with CIN alone. This demonstrates, as known by previous works, that the main component of this phytocomplex is responsible for antifungal properties [18][19][20]. EOs and their active components are generally characterized by some drawbacks such as high volatility, chemical instability, and low solubility in water, hence their limited use in medical therapy [21,22].…”

Section: Discussionsupporting

confidence: 75%

Cinnamaldehyde Loaded Poly(lactide-co-glycolide) (PLGA) Microparticles for Antifungal Delivery Application against Resistant Candida albicans and Candida glabrata

Rizzo,

Di Vito,

Mazzinelli

et al. 2023

Plants

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Researchers have explored natural products to combat the antibiotic resistance of various microorganisms. Cinnamaldehyde (CIN), a major component of cinnamon essential oil (CC-EO), has been found to effectively inhibit the growth of bacteria, fungi, and mildew, as well as their production of toxins. Therefore, this study aimed to create a delivery system for CIN using PLGA microparticles (CIN-MPs), and to compare the antifungal activity of the carried and free CIN, particularly against antibiotic-resistant strains of Candida spp. The first part of the study focused on synthesizing and characterizing the PLGA MPs, which had no toxic effects in vivo and produced results in line with the existing literature. The subsequent experiments analyzed the antifungal effects of MPs-CIN on Candida albicans and Candida glabrata, both resistant (R) and sensitive (S) strains and compared its efficacy with the conventional addition of free CIN to the culture medium. The results indicated that conveyed CIN increased the antifungal effects of the product, particularly towards C. albicans R. The slow and prolonged release of CIN from the PLGA MPs ensured a constant and uniform concentration of the active principle within the cells.

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Section: Discussionsupporting

confidence: 75%

Cinnamaldehyde Loaded Poly(lactide-co-glycolide) (PLGA) Microparticles for Antifungal Delivery Application against Resistant Candida albicans and Candida glabrata

Rizzo,

Di Vito,

Mazzinelli

et al. 2023

Plants

Self Cite

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“…The results indicated that Cinnamomum zeylanicum essential oil was most effective against C. auris (MIC; 0.06% v/v) in synergy with antifungal drug fluconazole. Further they verified that cinnamaldehyde was the sole reason for the antifungal activity [52]. In the same year, another group of researchers identified the antifungal potency of Cinnamomum cassia essential oil [53], this oil also rich in chemical constitute like cinnamaldehyde [54].…”

Section: Essential Oils Are the Potential Sources Of Novel Antifungal...mentioning

confidence: 94%

Current Perspectives of Antifungal Therapy: A Special Focus on <em>Candida auris</em>

Arumugam,

Muthuselvam,

Lima

et al. 2024

Preprint

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Candida auris is considered an emerging Candida species that has rapidly spread all over the world. The evidence of its origin and emerging resistance is still unclear. The severe infection by this species causes significant mortality and morbidity among the elderly and immune compressed individuals. Development of drug resistance is the major factor associated with therapeutic failure of existing antifungal agents. Previous studies addressed the antifungal resistance profile and drug discovery for C. auris. However, comprehensive coverage of these information in a single investigation yet to be available. In this review, we have mainly focused on recent development in therapeutic strategy against C. auris. Based on the available information, several differential approaches were discussed, including existing antifungal drugs, chemical compounds, essential oils, natural products, antifungal peptides, immunotherapy, antimicrobial photodynamic therapy, drug repurposing, and drug delivery systems. Among them, chemical medications, natural products, and antifungal peptides are the prime contributors. However, a limited number of resources are available to prove the efficiency of these potential therapies in clinical usage. Hence, we hope that the data gathered in this review can encourage in vivo studies and clinical trials.

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“…The results indicated that Cinnamomum zeylanicum essential oil was most effective against C. auris (MIC; 0.06% v / v ) in synergy with the antifungal drug fluconazole. Further they verified that cinnamaldehyde was the sole reason for the antifungal activity [ 58 ]. In the same year, another group of researchers identified the antifungal potency of Cinnamomum cassia essential oil [ 59 ], this oil also being rich in chemical compounds like cinnamaldehyde [ 60 ].…”

Section: Therapeutic Optionsmentioning

confidence: 99%

Current Perspectives of Antifungal Therapy: A Special Focus on Candida auris

Ganeshkumar,

Muthuselvam,

Lima

et al. 2024

JoF

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Candida auris is an emerging Candida sp. that has rapidly spread all over the world. The evidence regarding its origin and emerging resistance is still unclear. The severe infection caused by this species results in significant mortality and morbidity among the elderly and immunocompromised individuals. The development of drug resistance is the major factor associated with the therapeutic failure of existing antifungal agents. Previous studies have addressed the antifungal resistance profile and drug discovery for C. auris. However, complete coverage of this information in a single investigation is not yet available. In this review, we have mainly focused on recent developments in therapeutic strategies against C. auris. Based on the available information, several different approaches were discussed, including existing antifungal drugs, chemical compounds, essential oils, natural products, antifungal peptides, immunotherapy, antimicrobial photodynamic therapy, drug repurposing, and drug delivery systems. Among them, synthetic chemicals, natural products, and antifungal peptides are the prime contributors. However, a limited number of resources are available to prove the efficiency of these potential therapies in clinical usage. Therefore, we anticipate that the findings gathered in this review will encourage further in vivo studies and clinical trials.

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A New Potential Resource in the Fight against Candida auris: the Cinnamomum zeylanicum Essential Oil in Synergy with Antifungal Drug

Cited by 11 publications

References 42 publications

Cinnamaldehyde Loaded Poly(lactide-co-glycolide) (PLGA) Microparticles for Antifungal Delivery Application against Resistant Candida albicans and Candida glabrata

Cinnamaldehyde Loaded Poly(lactide-co-glycolide) (PLGA) Microparticles for Antifungal Delivery Application against Resistant Candida albicans and Candida glabrata

Current Perspectives of Antifungal Therapy: A Special Focus on <em>Candida auris</em>

Current Perspectives of Antifungal Therapy: A Special Focus on Candida auris

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