A New Porous Osteointegrative Bone Cement Material

Georgescu, Gabriela; Lacout, J.L.; Frèche, M.

doi:10.4028/www.scientific.net/kem.254-256.201

Cited by 4 publications

(4 citation statements)

References 10 publications

(4 reference statements)

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“…For the chemical foaming process, an in situ gas forming reaction is used, producing gas bubbles in the setting cement slip 19–23 . The prefoaming method, sometimes also described as mechanical foaming method, makes use of preformed surfactant 24–26 or protein‐stabilized 27,28 foams that are then mixed with the cement slip or the cement powder.…”

Section: Resultsmentioning

confidence: 99%

“…Currently, the main application fields of these methods are the production of light‐weight construction materials 21,24,25,35,36 or self‐setting macroporous bone scaffolds needed in bone surgery 19,20,22,23,26–28,30–34 . In comparison, the foams produced with the direct foaming method discussed herein are plotted in the same graph (note that not all the data included in this graph are discussed in the present publication).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Microstructural Control of Self-Setting Particle-Stabilized Ceramic Foams

Juillerat

Gonzenbach

Elser

et al. 2010

Journal of the American Ceramic Society

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The ability to tailor the microstructure of porous ceramics is essential in order to fulfill the requirements of various applications. Depending on the use of porous ceramics, microstructures with open or closed pores, adjustable pore sizes, and a possible self-setting ability of the wet foam are required. We present a direct foaming method to synthesize self-setting foams with controlled microstructures, based on our previous studies on particle-stabilized foams. For the experimental set-up, alumina particles were partially hydrophobized with propyl gallate and the resulting suspensions were combined with a calcium aluminate cement reaction. Pore size and the fraction of open pores can be controlled by the particle concentration and the setting rate of the cement reaction. As a result, self-setting ceramiccement composites with porosities ranging from 40 to 95 vol% and closed as well as open pores with sizes between 30 lm and 1 mm were achieved. Compared with other methods used to produce self-setting inorganic macroporous materials, foams made with this method cover a wider pore size and porosity range and reach higher total porosities.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Microstructural Control of Self-Setting Particle-Stabilized Ceramic Foams

Juillerat

Gonzenbach

Elser

et al. 2010

Journal of the American Ceramic Society

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“…So far, some experiments have been done by mixing the CPCs with crystals of highly soluble and nontoxic compounds such as sucrose, NaHCO 3 , NaHPO 4 ,13 Mannitol,14, 15 or by using the resorbable fibers,16 bubbling agents,17, 18 air‐entraining agent,19 and frozen particles20 into the CPCs composition. This study deals with the use of an effervescent additive in the components of a calcium phosphate cement (CPC) to produce interconnected macropores during setting.…”

Section: Introductionmentioning

confidence: 99%

Phase evaluation of an effervescent‐added apatitic calcium phosphate bone cement

2006

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Development of macroporosity during setting would allow fast bone ingrowth and good osteointegration of the implant. The interconnected macropores could be created in calcium phosphate cements (CPCs) through the addition of an effervescent porogen mixture to the component of the cements. But this addition could also affect other characteristics of CPCs, such as setting time, mechanical strength, extent of conversion of reactant to apatite phase, crystallinity, and chemical composition of apatite lattice. In this study, these properties were investigated in an effervescent-added calcium phosphate bone cement. From 0 to 20 wt % of an effervescent mixture was added to calcium phosphate cement (CPC) components and phase evaluations were performed after 24 h incubation at 37 degrees C and 28% relative humidity and 1, 3, 7, and 14 days immersion in a specific simulated body fluid. XRD and FTIR techniques were used to characterize the cement composition, crystallinity, and chemical groups in final CPCs. The results showed that addition of effervescent porogen affects the extent of conversion of reactant to apatite phase and crystallinity. In other words, using the effervescent porogen in CPCs could accelerate the rate of conversion of TTCP/DCPA reactant to apatite phase with smaller crystallites, so that it was the predominant phase (about 67%) after only 3 days soaking in SBF solution. The content of carbonate groups substituted for phosphate groups in apatite lattice increased when the effervescent additive was further added. The compressive strength of the set calcium phosphate cement decreased significantly with the addition of the effervescent agent and reached from 8 MPa for additive-free CPC to 1.3 MPa for 20% effervescent-added CPC. The compressive strength was improved after 3 days immersing of CPC in the simulated body fluid solution.

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“…The macroporosity can be produced by the addition of some gas-generating compounds, such as hydrogen peroxide 18 or sodium bicarbonate. [19][20][21] However, the liberation of gas after the implantation of the cement paste could have harmful effects for the organism. In this work, we propose to create the macroporosity by mixing the cement paste with a foam obtained from a foaming agent.…”

Section: Introductionmentioning

confidence: 99%

Factors affecting the structure and properties of an injectable self‐setting calcium phosphate foam

Ginebra¹,

Delgado²,

Harr³

et al. 2006

J Biomedical Materials Res

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One of the main challenges in the investigation on calcium phosphate cements (CPC) lies in the introduction of macroporosity, without loosing the self-setting ability and injectability, characteristic of the cement-type materials. The benefits of macroporosity are related to the enhancement of bone regeneration mechanisms, such as angiogenesis and tissue ingrowth. In this work, the feasibility to obtain self-setting injectable macroporous hydroxyapatite foams by the incorporation of a protein-based foaming agent to a CPC is demonstrated. Albumen is combined with an alpha-tricalcium phosphate [Ca3(PO4)2, alpha-TCP] paste, which hydrolyzes to a calcium deficient hydroxyapatite during the setting reaction. A systematic study is presented, where the effect of different processing parameters is analyzed in terms of porosity, setting properties, injectability, and compressive strength. Self-setting foams with porosities up to 70%, which maintain their porous structure after injection, are obtained. These injectable foams can be used both for direct in vivo applications and for the fabrication of low temperature tissue engineering scaffolds.

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A New Porous Osteointegrative Bone Cement Material

Cited by 4 publications

References 10 publications

Microstructural Control of Self-Setting Particle-Stabilized Ceramic Foams

Microstructural Control of Self-Setting Particle-Stabilized Ceramic Foams

Phase evaluation of an effervescent‐added apatitic calcium phosphate bone cement

Factors affecting the structure and properties of an injectable self‐setting calcium phosphate foam

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