A New Phloroglucinol Derivative from the Brown Alga Eisenia bicyclis:  Potential for the Effective Treatment of Diabetic Complications

Abstract

A new phloroglucinol derivative (1) and two known compounds (2 and 3) were isolated from the brown alga Eisenia bicyclis. These isolates exhibit inhibitory activity on glycation and alpha-amylase. Their structures were determined on the basis of spectroscopic data.

Isolation of a New Anti-Allergic Phlorotannin, Phlorofucofuroeckol-B, from an Edible Brown Alga,Eisenia arborea

“…These algae are known to contain several phlorotannins, viz., eckol, 1) dieckol, 1) 6,6 0 -bieckol, 2) 8,8 0 -bieckol, 2) and phlorofucofuroeckol-A (PFF-A). 3) Phlorotannins have been reported to have certain biological activities, such as antioxidation, 4) bactericide, 5) anti-cancer, 6) anti-diabetic complications, 7,8) and chemoprevention against several vascular diseases. 9,10) Although some anti-inflammatory activities of phlorotannins have also been reported, 11,12) their inhibitory effect on histamine release from the stimulated cultured cells is still unknown.…”

Immunomodulatory Effects of Eisenia bicyclis on Innate Immune Cells in Acute Exercise-Stress Rat Model

“…Furthermore EBE has been known to have anti-oxidant effects and antiinflammatory effects (Okada et al, 2004;Whitaker and Carlson, 1975 As shown in Fig. 1A and Fig.…”

Quinone Reductase Induction Activity of Phlorotannins Derived from Eisenia bicyclis in Hepa1c1c7 Cells

“…The plates were then agitated on a shaker (120 rpm) for 10 min at room temperature. A 200 µL aliquot of reaction solution (7.5 mL of 0.5 M Tris HCl buffer, pH 7.4; 100 mg of albumin from human serum; 1 mL of 1.5% Tween 20 solution; 0.1 mL of 7.5 mM FAD; 1 mL of 150 mM glucose 6-phosphate; 90 µL of 50 mM NADP; 300 U of yeast glucose 6-phosphate dehydrogenase; 45 mg of MTT; 150 µL of 50 Nakamura et al, 1996;Okada et al, 2004;Jung et al, 2010;Yoon et al, 2011). In particular, phlorotannins, the major metabolites of Eisenia and Ecklonia species, are polyphenolic compounds that have a variety of positive physiological effects such as antioxidation, antidementia, antihyperlipidemic, and angiotensin-converting enzyme I and tyrosinase inhibitory activities (Kang et al, 2004;Jung et al, 2006Jung et al, , 2010Yoon et al, 2008Yoon et al, , 2009.…”