A new N-hydroxyethyliminodiacetic acid modified core–shell silica phase for chelation ion chromatography of alkaline earth, transition and rare earth elements

McGillicuddy, Nicola; Nesterenko, Ekaterina P.; Nesterenko, Pavel N.; Stack, Elaine M.; Omamogho, Jesse O.; Glennon, Jeremy D.; Paull, Brett

doi:10.1016/j.chroma.2013.10.057

Cited by 9 publications

(1 citation statement)

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“…New bonded phases such as N-hydroxyethyliminodiacetic acid for chromatography of 14 lanthanides and yttrium [133], anthracenyl-phase for the aromatic selectivity [134] have been developed. A variety of brush-type chiral stationary phases [135] were synthesized, and a hydroxypropyl-β-cyclodextrin-phase [136] and a quinine-phase [137] were also synthesized and their high-speed separation was demonstrated by comparison with their related FPP packing materials.…”

Section: Applications Of Superficially Porous Packing Materialsmentioning

confidence: 99%

Fundamental Properties of Packing Materials for Liquid Chromatography

Hanai¹

2019

Separations

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The high performance of chemically-modified silica gel packing materials is based on the utilization of pure silica gels. Earlier silica gels used to be made from inorganic silica; however, nowadays, silica gels are made from organic silanes. The surface smoothness and lack of trace metals of new silica gels permits easy surface modifications (chemical reactions) and improves the reproducibility and stability. Sharpening peak symmetry is based on developing better surface modification methods (silylation). Typical examples can be found in the chromatography of amitriptyline for silanol testing and that of quinizarin for trace metal testing. These test compounds were selected and demonstrated sensitive results in the measurement of trace amounts of either silanol or trace metals. Here, we demonstrate the three-dimensional model chemical structures of bonded-phase silica gels with surface electron density for easy understanding of the molecular interaction sites with analytes. Furthermore, a quantitative explanation of hydrophilic and hydrophobic liquid chromatographies was provided. The synthesis methods of superficially porous silica gels and their modified products were introduced.

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