A new monoterpene glucoside and complete assignments of dihydroflavonols of<i>Pulicaria jaubertii</i>: potential cytotoxic and blood pressure lowering activity

Ragab, Ehab A.; Raafat, Mohamed

doi:10.1080/14786419.2015.1055492

Cited by 25 publications

(25 citation statements)

References 19 publications

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“…The EtOAc extract was the most active and was not toxic to RBL-2H3 cells (Figure 1). This extract was subjected to silica gel column chromatography, Sephadex LH-20 column chromatography, and RP HPLC to yield ten known flavonoids, such as, padmatin ( 1 ) [14], aromadendrin ( 2 ) [15], apigenin ( 3 ) [16], (2 R , 3 S , 2′’ R , 3′’ S )-wikstaiwanone C ( 4 ) [17], taxifolin ( 5 ) [14], (2 R , 3 R , 2′’ R , 3′’ S )-neochamaejasmine B ( 6 ) [18], (2 S , 3 R , 2′’ S , 3′’ R )-chamaejasmine ( 7 ) [18], naringenin ( 8 ) [16], afzelechin ( 9 ) [19], and catechin ( 10 ) [20] (Figure 2). These ten flavonoids were identified using 2D-NMR and HR-MS data.…”

Section: Resultsmentioning

confidence: 99%

Chamaejasmine Isolated from Wikstroemia dolichantha Diels Suppresses 2,4-Dinitrofluoro-benzene-Induced Atopic Dermatitis in SKH-1 Hairless Mice

et al. 2019

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Plants of the genus Wikstroemia have long been used as traditional medicines to treat diseases like pneumonia, rheumatism, and bronchitis. This study was designed to determine the effect of chamaejasmine, a biflavonoid present in W. dolichantha, on atopic dermatitis (AD)-like skin lesions in a 2,4-dinitrochlorobenzene (DNCB)-induced murine model of AD. Initially, we examined the anti-allergic activities of ten flavonoids from W. dolichantha by measuring β-hexosaminidase release from RBL-2H3 cells. Subsequently, an SKH-1 hairless mouse model of AD was developed based on the topical application of DNCB. Chamaejasmine (0.5%) or pimecrolimus (1%, positive control) were applied to dorsal skins of DNCB-sensitized AD mice for two weeks. Serum IL-4 and IgE levels were determined using enzyme-linked immunosorbent assay kits and transepidermal water loss (TEWL) and skin hydration were measured using a Tewameter TM210 and a SKIN-O-MAT, respectively. Of the ten flavonoids isolated from W. dolichantha, chamaejasmine most potently inhibited DNP-specific IgE-induced degranulation in RBL-2H3 cells. Topical administration of chamaejasmine attenuated the clinical symptoms of DNCB-induced dermatitis (i.e., itching, dryness, erythema, and edema). Histological analyses demonstrated that dermal thickness and mast cell infiltration in dermis were significantly reduced by chamaejasmine. In addition, 0.5% chamaejasmine inhibited DNCB-induced increases in total IL-4 and IgE levels in serum, improved skin barrier function, and increased epidermis moisture. Our findings suggest chamaejasmine might be an effective therapeutic agent for the treatment of atopic diseases.

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Section: Resultsmentioning

confidence: 99%

Chamaejasmine Isolated from Wikstroemia dolichantha Diels Suppresses 2,4-Dinitrofluoro-benzene-Induced Atopic Dermatitis in SKH-1 Hairless Mice

et al. 2019

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“…Pure compound 9 was identified from spectroscopic data as maltol 3-[6″-(2-(E)-butenoyl)-glucoside]. Ten other compounds were identified in SCAE by comparing 1 H-NMR, 13 C-NMR, and MS data with literature values; these compounds were benzoic acid (1), 20 daphnoretin (2), 21 apigenin 3, 22 genkwanin (4), 23 taxifolin 5, 24 apigenin 7-Oglucoside (6), 25 luteolin 7-Osambubioside 7, 26 genkwanin 5-Oglucoside (8), 27,28 matairesinoside (10), 29 and lariciresinol (11). 30 A β-hexosaminidase assay was used to assess the antiallergic effects of the 11 compounds isolated from S. chamaejasme (Figure 3).…”

Section: Resultsmentioning

confidence: 99%

Antiallergic Effects of Phenolic Compounds Isolated From Stellera chamaejasme on RBL-2H3 Cells

Bong

Jegal

et al. 2020

Natural Product Communications

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The current study was undertaken to isolate and identify anti-inflammatory and antiallergic active compounds in the ethyl acetate and butanol fractions of an ethanolic extract of the aerial parts of Stellera chamaejasme (SCAE). A new maltol glucoside, maltol 3-(6″-(2-( E)-butenoyl)-glucoside) and benzoic acid, daphnoretin (a coumarin), 6 flavonoids (apigenin, genkwanin, taxifolin, apigenin 7- O-glucoside, luteolin 7- O-sambubioside, genkwanin 5- O-glucoside), and 2 lignans (matairesinoside and lariciresinol) were isolated from SCAE by chromatographic separation. Their chemical structures were elucidated by analyzing spectroscopic data, including 1-dimensional and 2-dimensional nuclear magnetic resonance (Fig1). Maltol 3-(6″-(2-( E)-butenoyl)-glucoside) significantly inhibited β-hexosaminidase release by 85.5% in immunoglobulin E and dinitrophenyl/bovine serum albumin (DNP/BSA)-induced RBL-2H3 cells. Benzoic acid from S. chamaejasme inhibited β-hexosaminidase release (by 80.2%) in IgE and DNP/BSA-induced RBL-2H3 cells and interleukin-4 messenger ribonucleic acid expression (by 21.9% inhibition) in propidium iodide-induced RBL-2H3 cells.

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“…Furthermore, dihydrochalcones are widely found in apple trees, other edible and medicinal plants 29 . Dihydroflavonols are mainly isolated from diets bicolour (Iridaceae), willow and pulicaria jaubertii 30‐32 …”

Section: Brief Overview Of Flavonoids: Structure Classification and Main Sourcesmentioning

confidence: 99%

Immunomodulatory potential of flavonoids for the treatment of autoimmune diseases and tumour

Han

Deng³

et al. 2021

Scand J Immunol

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The immune system plays an indispensable role in maintaining human health against the invasion of foreign materials, microorgainisms and pathogens. The autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses resulting in excessive and uncontrolled tissue inflammation, as well as tumour, and others. In recent years, flavonoids are widely recognized as potentially natural polyphenol compounds for the treatment of multiple diseases, given their immunomodulatory activity, antioxidant and antineoplastic activities. However, the exact mechanisms of flavonoids on the immune system and inhibiting tumour remains unclear. This review article provides an overview of the impact and mechanism of flavonoids on innate and adaptive immune system through the analysis of various immune cells. Meanwhile, we also explain the probable therapeutic mechanism of flavonoids on tumour and other chronic diseases. Overall, this review may provide a certain theoretical direction and theoretical basis for the application of flavonoids in the treatment of immune‐related disorders and tumour.

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A new monoterpene glucoside and complete assignments of dihydroflavonols ofPulicaria jaubertii: potential cytotoxic and blood pressure lowering activity

Cited by 25 publications

References 19 publications

Chamaejasmine Isolated from Wikstroemia dolichantha Diels Suppresses 2,4-Dinitrofluoro-benzene-Induced Atopic Dermatitis in SKH-1 Hairless Mice

Chamaejasmine Isolated from Wikstroemia dolichantha Diels Suppresses 2,4-Dinitrofluoro-benzene-Induced Atopic Dermatitis in SKH-1 Hairless Mice

Antiallergic Effects of Phenolic Compounds Isolated From Stellera chamaejasme on RBL-2H3 Cells

Immunomodulatory potential of flavonoids for the treatment of autoimmune diseases and tumour

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