Road safety depends on humans, vehicles, and highway conditions. These factors influence road safety separately or in combination. Despite these facts, the police report indicated that only a single cause of accident has been reported for a given accident in Ethiopia and the number of accidents that had been caused by road defect accounted around 1% of total accidents per year, which underestimates its contribution to road accidents. Beside these facts, only a few studies were carried out in Ethiopia on this issue. Even though dangerous road segments were identified and ranked along the same study area of this paper in our previous publication, Hawassa-Shashemene-Bulbula two-lane rural highway, the influences of road geometric parameters on road safety were not correlated along this study area. Therefore, it is imperative to clarify the relationship between the expected number of traffic accidents and the geometric conditions of the road under study to reduce accidents and provide safe driving environment. The main objective of this study was to quantify the influence of road geometric parameters on road safety. Using historical accident data, traffic data, and road data, the expected numbers of accidents were estimated by using the empirical Bayes (EB) method. Then, the expected numbers of accidents have been correlated with one or more road geometric parameters at a time. Accordingly, the identified dangerous road segments in the previous publication