A new method for early diagnosis of liver cancer using a biosensor embedded in an alginate polymer thin film

Abstract

Hepatocellular carcinoma (HCC) has become a pressing health problem facing the world today due to its high morbidity, high mortality, and late discovery. As a diagnostic criterion of HCC, the...

Novel sensor for the determination of CA 15-3 in serum of breast cancer patients based on Fe–gallic acid complex doped in modified cellulose polymer thin films

“…The presence of new groups along the polymer chains affected the arrangement of the molecules during the casting process, which led to a perturbation of the crystal arrangement and the formation of structural lms with a rough surface. 29 Immobilized CA 15-3 antibody interaction with CA 15-3 created a coating layer which led the surface prole to be smoother as shown in Fig. 4c.…”

Calcium Alginate as an Active Device Component for Light-Triggered Degradation of 2D MoS2-Based Transient Electronics

“…In pursuing the natural biopolymer of Ca-AR as the medium to introduce the afore-discussed multifunctional transient characteristics, we extensively consider its material properties suitable for transient electronics, i.e., intrinsic biocompatibility, photodegradability owing to its constituent riboflavin, as well as ability to donate mobile ions to create EDLs with a redistributed charge density, all of which have been difficult to accomplish in single solution-based electrolyte materials. − Sodium alginates, linear polysaccharide salts of alginic acid, are unbranched copolymers of equatorial β- d -mannuronate (M block), and axial α- l -guluronate (G block) possess an inherent affinity to cross-link with polyvalent metal ions . The stoichiometric ratio of ions, such as Ca 2+ and COOH – ions, determines the extent of gelation, solubility, conductivity, and mechanical stiffness of calcium alginate hydrogels, films, capsules, and fibers. − While calcium alginate-based materials have been extensively used in biomedical applications for decades, their integration into electronic and/or optoelectronic devices recently drew attention, , mainly due to their intrinsic dielectric properties as passive device components . Following the preparation of calcium alginate in a thin film form, isoalloxazine riboflavin 7,8-dimethyl-10­(1′- d -ribityl), an essential nutrient in animal and plant metabolism is incorporated into the film.…”

“…32 The stoichiometric ratio of ions, such as Ca 2+ and COOH − ions, determines the extent of gelation, solubility, conductivity, and mechanical stiffness of calcium alginate hydrogels, films, capsules, and fibers. 33−35 While calcium alginate-based materials have been extensively used in biomedical applications for decades, their integration into electronic and/or optoelectronic devices recently drew attention, 36,37 mainly due to their intrinsic dielectric properties as passive device components. 38 Following the preparation of calcium alginate in a thin film form, isoalloxazine riboflavin 7,8-dimethyl-10(1′-D-ribityl), an essential nutrient in animal and plant metabolism 39 is incorporated into the film.…”

Numerical analysis of microwave and radiofrequency ablations: A novel design for electrode-based radiofrequency ablation

“…The normal liver tissue is considered a cylinder with a height and radius of 80 𝑚𝑚 and 30 𝑚𝑚, respectively. Since more than 56% of cancer tumors are spherical 43 , we consider the tumor part to be a sphere with a radius of 10 𝑚𝑚. As illustrated in Fig.…”