A New Look at Scarring Alopecia

Sperling, Leonard C.; Solomon, Alvin R.; Whiting, David

doi:10.1001/archderm.136.2.235

Cited by 140 publications

(159 citation statements)

References 9 publications

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“…At present, the majority of idiopathic noninflammatory scarring alopecia cases are diagnosed as nonspecific scarring alopecia or pseudopelade, and the eponym Brocq is rarely used. However, several authors have proposed to exclude completely the term pseudopelade to avoid confusion [19,20,38]. In our series, the results agree with this theory: the 6 cases initially suspected of being PB due to clinical picture and history were finally classified as another entity due to the histology and DIF results.…”

Section: Discussionsupporting

confidence: 85%

Primary Scarring Alopecia: Clinical-Pathological Review of 72 Cases and Review of the Literature

Villablanca

Fischer

García-García

et al. 2017

Skin Appendage Disord

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Purpose of the Study: To analyze the epidemiologic, demographic, clinical, and histological characteristics of primary scarring alopecia (PSA) cases diagnosed over a 7-year period at the Department of Dermatology, Hospital Clinic, Barcelona, Spain. Procedures: Seventy-two patients diagnosed with PSA between 2006 and 2012 were included. Age, sex, ethnic group, clinical pattern, predominant histological infiltrate, final clinical diagnosis, time of onset, treatments used, and clinical evolution were evaluated and correlated. Results: The ethnic groups were distributed as follows: 93% European-Caucasian, 5% Mestizo-American, 1% oriental, and 1% Afro-American. Most cases were females (71%), and mean age was 51 ± 6 years. The follicular pattern was the most common, and the predominant inflammatory infiltrate was lymphocytic. Lichen planopilaris and frontal fibrosing alopecia were the main diagnoses. When correlating clinical aspects and histopathology, lymphocytic PSAs had a subacute onset and resulted in a nonchanging, more stable form, while neutrophilic PSAs had a more acute onset with an evolution of acute outbreaks. PSAs in a late stage with an absent/mild infiltrate had a subclinical onset and a slowly progressive or stable evolution. Conclusions: The PSAs are severe trichological conditions. Their high clinical and histopathological variability make them a diagnostic and therapeutic challenge. Message of the Paper: Knowing the clinical and histopathological aspects of PSAs should be of crucial importance to the dermatologist.

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Section: Discussionsupporting

confidence: 85%

Primary Scarring Alopecia: Clinical-Pathological Review of 72 Cases and Review of the Literature

Villablanca

Fischer

García-García

et al. 2017

Skin Appendage Disord

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“…Hair loss centered on the crown of the scalp, chronic and progressive disease with eventual ''burnout'', symmetrical expansion with the most active disease at the periphery, and clinical and histologic evidence of inflammation in the active peripheral zone were described as common features of CCSA. 16 The term FDS was included under the subset of CCSA, as was pseudopelade (not to be confused with classic pseudopelade of Brocq) and folliculitis decalvans. While FDS was described to be a form of CCSA, it was noted that FDS demonstrated the distinctive histologic finding of premature desquamation of the IRS in both inflamed follicles and non-inflamed ''normal'' scalp.…”

Section: Ccca: An Evolving Nomenclature and Descriptionmentioning

confidence: 99%

Central centrifugal cicatricial alopecia: Past, present, and future

Gathers¹,

Lim²

2009

Journal of the American Academy of Dermatology

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“…2,3,[14][15][16] Sperling et al 14 has attempted to redefine pseudopelade of Brocq, follicular degeneration syndrome, and FD as subsets of central centrifugal scarring alopecia. In the recent NAHRS classification on cicatricial alopecia, classic pseudopelade of Brocq and central centrifugal alopecia belong to 2 distinct entities.…”

Section: Lymphocytic Cicatricial Alopeciasmentioning

confidence: 99%