A new learning model for submissive behavior in mice: Effects of naloxone

Long-term analgesic reaction in attacked mice.

“…Such a conditioned amine depletion may eventually have been responsible for the nonopioid component of long-term analgesia observed in our case. However, one has to consider that the effects of opioid antagonists on LTA may not be limited to their analgesia-blocking properties; they may also have an enhancing effect on memory for experience of social conflict (Siegfried, Frischknecht, & Waser, 1982), or they may increase the aversiveness of bites, which may interact with the form of the analgesia (Fanselow, 1984; Terman et al, 1984).…”

Long-term analgesic reaction in attacked mice.

“…Such a conditioned amine depletion may eventually have been responsible for the nonopioid component of long-term analgesia observed in our case. However, one has to consider that the effects of opioid antagonists on LTA may not be limited to their analgesia-blocking properties; they may also have an enhancing effect on memory for experience of social conflict (Siegfried, Frischknecht, & Waser, 1982), or they may increase the aversiveness of bites, which may interact with the form of the analgesia (Fanselow, 1984; Terman et al, 1984).…”

Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake

“…Repeated defeat followed by individual housing results in long-term impaired social memory, decreased social interaction and diminished anticipation for a sucrose reward up to 3 months after the last defeat experience, as well as attenuated induction of long-term potentiation and suppressed facilitation of long-term depression in the CA1 region of the hippocampus (Von Frijtag et al, 2001). Animals learn rapidly when to be submissive (Siegfried et al, 1982) and display submissive behavior more readily in successive confrontations (Ginsburg & Allee, 1942; Scott & Marston, 1953; Leshner & Nock, 1976). …”

Assessing activity onset time and efficacy for clinically effective antidepressant and antimanic drugs in animal models based on dominant–submissive relationships

“…Second, by mutually accepted priority of access to different resources (Masur and Benedito, 1974;Malatynska and Kostowski, 1984;Zagrodzka et al, 1987;Fonberg, 1988;Gentsch et al, 1988b;Mitchell and Redfern, 1992). The third is based on animal territoriality such as the relationship between resident and intruder animals (Willner et al, 1981Siegfried et al, 1982;Kudryavtseva et al, 1991). All these approaches evaluate animal behavior for an extended duration and researchers can collect data at different time intervals.…”

Long-term analgesic reaction in attacked mice.

“…Such a conditioned amine depletion may eventually have been responsible for the nonopioid component of long-term analgesia observed in our case. However, one has to consider that the effects of opioid antagonists on LTA may not be limited to their analgesia-blocking properties; they may also have an enhancing effect on memory for experience of social conflict (Siegfried, Frischknecht, & Waser, 1982), or they may increase the aversiveness of bites, which may interact with the form of the analgesia (Fanselow, 1984; Terman et al, 1984).…”

Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake

“…Repeated defeat followed by individual housing results in long-term impaired social memory, decreased social interaction and diminished anticipation for a sucrose reward up to 3 months after the last defeat experience, as well as attenuated induction of long-term potentiation and suppressed facilitation of long-term depression in the CA1 region of the hippocampus (Von Frijtag et al, 2001). Animals learn rapidly when to be submissive (Siegfried et al, 1982) and display submissive behavior more readily in successive confrontations (Ginsburg & Allee, 1942; Scott & Marston, 1953; Leshner & Nock, 1976). …”

Assessing activity onset time and efficacy for clinically effective antidepressant and antimanic drugs in animal models based on dominant–submissive relationships

“…Second, by mutually accepted priority of access to different resources (Masur and Benedito, 1974;Malatynska and Kostowski, 1984;Zagrodzka et al, 1987;Fonberg, 1988;Gentsch et al, 1988b;Mitchell and Redfern, 1992). The third is based on animal territoriality such as the relationship between resident and intruder animals (Willner et al, 1981Siegfried et al, 1982;Kudryavtseva et al, 1991). All these approaches evaluate animal behavior for an extended duration and researchers can collect data at different time intervals.…”

Long-term analgesic reaction in attacked mice.

“…Such a conditioned amine depletion may eventually have been responsible for the nonopioid component of long-term analgesia observed in our case. However, one has to consider that the effects of opioid antagonists on LTA may not be limited to their analgesia-blocking properties; they may also have an enhancing effect on memory for experience of social conflict (Siegfried, Frischknecht, & Waser, 1982), or they may increase the aversiveness of bites, which may interact with the form of the analgesia (Fanselow, 1984; Terman et al, 1984).…”

Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake

“…Repeated defeat followed by individual housing results in long-term impaired social memory, decreased social interaction and diminished anticipation for a sucrose reward up to 3 months after the last defeat experience, as well as attenuated induction of long-term potentiation and suppressed facilitation of long-term depression in the CA1 region of the hippocampus (Von Frijtag et al, 2001). Animals learn rapidly when to be submissive (Siegfried et al, 1982) and display submissive behavior more readily in successive confrontations (Ginsburg & Allee, 1942; Scott & Marston, 1953; Leshner & Nock, 1976). …”

Assessing activity onset time and efficacy for clinically effective antidepressant and antimanic drugs in animal models based on dominant–submissive relationships

“…Second, by mutually accepted priority of access to different resources (Masur and Benedito, 1974;Malatynska and Kostowski, 1984;Zagrodzka et al, 1987;Fonberg, 1988;Gentsch et al, 1988b;Mitchell and Redfern, 1992). The third is based on animal territoriality such as the relationship between resident and intruder animals (Willner et al, 1981Siegfried et al, 1982;Kudryavtseva et al, 1991). All these approaches evaluate animal behavior for an extended duration and researchers can collect data at different time intervals.…”