Biochemical Pharmacology volume 77, issue 8, P1364-1373 2009 DOI: 10.1016/j.bcp.2009.01.011 View full text
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Fu-Chao Liu, Chang-Hui Liao, Yao-Wen Chang, Jiin-Tarng Liou, Yuan-Ji Day

Abstract: Sirtinol, a cell permeable six-membered lactone ring, is derived from naphthol and potent inhibitor of SIR2 and its naphtholic may have the inhibitory effects on platelets aggregation. In this study, platelet function was examined by collagen/epinephrine (CEPI) and collagen/ADP-induced closure times using the PFA-100 system reveal that CEPI-CT and CADP-CT were prolonged by sirtinol. The platelets aggregation regulated by physiological agonists such as: thrombin, collagen and AA and U46619 were significantly in…

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