A new <i>ent</i>-abietane lactone from <i>Glycosmis pentaphylla</i>

Chokchaisiri, Suwadee; Apiratikul, Nuttapon; Rukachaisirikul, Thitima

doi:10.1080/14786419.2018.1540477

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…In studies in China, a number of prenylated sulfur-containing amides and a phenolic glycoside (tachioside) ( 17 ) ( Figure 6 ) isolated from this plant also exhibited anti-inflammatory activity via downregulation of nitric oxide (NO) production in LPS-stimulated RAW 264.7 macrophages ( Tian et al, 2014 ; Nian et al, 2020 ). Numerous other compounds have been isolated from this plant, including anti-inflammatory stigmasterol ( 10 ) ( Figure 5 ), vanillic acid ( 18 ) ( Siddiqui et al, 2019 ; Soma et al, 2019 ; Chokchaisiri et al, 2020 ; Ziadlou et al, 2020 ), and glycopentalone ( 19 ) ( Figure 6 ) ( Sreejith and Asha, 2015 ; Sasidharan and Vasumathi, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Medicinal Plants of Bangladesh—A Pharmacological Evaluation

Akhtar

2022

Front. Pharmacol.

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Inflammatory diseases are considered major threats to human health worldwide. In Bangladesh, a number of medicinal plants have been used in traditional medicine from time immemorial in the treatment of diverse diseases, including inflammatory disorders. This assignment aims at providing the status of the medicinal plants of Bangladesh which are traditionally used in the management of inflammatory disorders and are investigated for their anti-inflammatory prospects using different preclinical studies and future research directions. The information of medicinal plants assembled in this review was obtained from a literature search of electronic databases such as Google Scholar, PubMed, Scopus, Web of Science and ScienceDirect up to December, 2020 from publications on plants investigated for their anti-inflammatory activities, in which the place of plant sample collection was identified as Bangladesh. Keywords for primary searches were “anti-inflammatory,” “Bangladeshi,” and “medicinal plants.” Criteria followed to include plant species were plants that showed significant anti-inflammatory activities in 1) two or more sets of experiments in a single report, 2) same or different sets of experiments in two or more reports, and, 3) plants which are traditionally used in the treatment of inflammation and inflammatory disorders. In this study, 48 species of medicinal plants have been reviewed which have been used in traditional healing practices to manage inflammatory disorders in Bangladesh. The mechanistic pathways of the in vivo and in vitro study models used for the evaluation of anti-inflammatory properties of plant samples have been discussed. Selected plants were described in further detail for their habitat, anti-inflammatory studies conducted in countries other than Bangladesh, and anti-inflammatory active constituents isolated from these plants if any. Medicinal plants of Bangladesh have immense significance for anti-inflammatory activity and have potential to contribute toward the discovery and development of novel therapeutic approaches to combat diseases associated with inflammation. However, the plants reviewed in this article had chiefly undergone preliminary screening and require substantial investigations including identification of active molecules, understanding the mechanism of action, and evaluation for safety and efficacy to be followed by the formulation of safe and effective drug products.

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Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Medicinal Plants of Bangladesh—A Pharmacological Evaluation

Akhtar

2022

Front. Pharmacol.

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“…The isolated diterpenoids were identified as 2-acetoxyljolkinolide A (1), jolkinolide A (2) [15], jolkinolide B (3) [16], 17-hydroxyljolkinolide A (4) [17], 17-hydroxyljolkinolide B (5) [17], 17-acetyljolkinolide A (6) [17], 17-acetyljolkinolide B (7) [18], jolkinolide E (8) [19], euphopilolide (9) [20], ent-abieta-8,11,13-triene-7-one (10) [21], 6β-hydroxy-ent-abieta-8,11,13-triene (11) [22] according to the literature. The spectra were shown in the Supplementary Materials.…”

Section: Structure-activity Relationshipmentioning

confidence: 99%

Chemical Composition, Anti-Breast Cancer Activity and Extraction Techniques of Ent-Abietane Diterpenoids from Euphorbia fischeriana Steud

Chen

et al. 2022

Molecules

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Ent-abietane diterpenoids are the main active constituents of Euphorbia fischeriana. In the continuing search for new anti-breast cancer drugs, 11 ent-abietane diterpenoids (1–11) were isolated from E. fischeriana. The structures of these compounds were clearly elucidated on the basis of 1D and 2D NMR spectra as well as HRESIMS data. Among them, compound 1 was a novel compound, compound 10 was isolated from Euphorbia genus for the first time, compound 11 was firstly discovered from E. fischeriana. These compounds exhibited varying degrees of growth inhibition against the MCF-10A, MCF-7, ZR-75-1 and MDA-MB-231 cell lines in vitro. The experimental data obtained permit us to identify the roles of the epoxy group, hydroxyl group and acetoxyl group on their cytotoxic activities. Extraction is an important means for the isolation, identification, and application of valuable compounds from natural plants. To maximize yields of ent-abietane diterpenoids of E. fischeriana, 17-hydroxyjolkinolide B, jolkinolide B, 17-hydroxyjolkinolide A and jolkinolide A were selected as quality controls to optimize the salting-out-assisted liquid–liquid extraction (SALLE) by response surface methodology (RSM). The optimized conditions for SALLE were 0.47 g sodium dihydrogen phosphate, 5.5 mL acetonitrile and 4.5 mL water at pH 7.5. The experimental values of 17-hydroxyjolkinolide B, jolkinolide B, 17-hydroxyjolkinolide A and jolkinolide A (2.134, 0.529, 0.396, and 0.148 mg/g, respectively) were in agreement with the predicted values, thus demonstrating the appropriateness of the model.

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Abietane‐Type Diterpenoids: Insights into Structural Diversity and Therapeutic Potential

Sargazifar,

Ghorbanian Charami,

Esmaeilzadeh Kashi

et al. 2024

Chemistry & Biodiversity

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The abietane‐type diterpenoids are among the most significant diterpene subsets found in hundreds of plant species belonging to various families. Among which, the members of the genus Salvia and Euphorbia are rich in abietane diterpenoids. Because of the chemical diversity and notable bioactivities, such as anticancer, antiinflammatory, antimicrobial, and antioxidant activities, abietane‐type diterpenoids are attractive. Herein, recent advances in the isolation and characterization of abietane‐type diterpenoids from natural sources, as well as their biological activities, from 2015 up to 2024 are reviewed. During this time, over 300 abietane diterpenoids with diverse structures have been discovered.

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A new ent-abietane lactone from Glycosmis pentaphylla

Cited by 7 publications

References 28 publications

Anti-Inflammatory Medicinal Plants of Bangladesh—A Pharmacological Evaluation

Anti-Inflammatory Medicinal Plants of Bangladesh—A Pharmacological Evaluation

Chemical Composition, Anti-Breast Cancer Activity and Extraction Techniques of Ent-Abietane Diterpenoids from Euphorbia fischeriana Steud

Abietane‐Type Diterpenoids: Insights into Structural Diversity and Therapeutic Potential

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