A new fructose-free, resistant-starch type IV-enriched enteral formula improves  glycaemic control and cardiovascular risk biomarkers when administered for six  weeks to elderly diabetic patients

Mesa, María Dolores; García-Rodríguez, Cruz Erika; Rico, María de la Cruz; Aguilera, Concepción M.; Pérez-Rodríguez, Milagros; Perez-de-la-Cruz, Antonio J; Gil, Ángel

doi:10.20960/nh.978

Cited by 10 publications

(12 citation statements)

References 30 publications

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“…The mean decrease in HbA1c in our results was 0•3 %, similar to the decrease reported in other studies (32,33) . In our study, these effects were observed without any change in the anti-diabetic medication.…”

Section: Variablessupporting

confidence: 92%

“…In elderly fragile patients with type 2 diabetes, who used an enteral diabetes-specific formula containing RS IV for 6 weeks, a reduction in the dietary glycaemic response has been proposed as a way to explain the response to the risk of diabetes complications (32) . HbA1c, E-selectin and monocyte chemo attractant protein-1 were significantly decreased, tending to decrease the soluble vascular cell adhesion molecule and plasminogen activator inhibitor-1.…”

Section: Variablesmentioning

confidence: 99%

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Beneficial effects of green banana biomass consumption in patients with pre-diabetes and type 2 diabetes: a randomised controlled trial

et al. 2019

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Diabetes mellitus is a global epidemic, characterised as a heterogeneous group of metabolic disorders associated with high risk of CVD. Green banana biomass, which is composed of resistant starches (RS) and cannot be hydrolysed by amylases, delays gastric emptying and modulates insulin sensitivity, thus contributing to improve metabolic disorders. The aim of the present study was to investigate the effects of consumption of RS from green banana biomass on body composition, fasting plasma glucose, glycated Hb (HbA1c) and homeostasis model assessment of insulin resistance in subjects with pre-diabetes or type 2 diabetes on top of treatment. Middle-aged subjects (n 113) of both sexes with pre-diabetes (HbA1c: 5·7–6·4 %) or diabetes (HbA1c ≥ 6·5 %) were randomised to receive nutritional support plus green banana biomass (40 g) (RS: approximately 4·5 g, G1, n 62) or diet alone (G2, n 51) for 24 weeks. Body composition, biochemical analyses and dietary intake were evaluated at the beginning and end of the study. In the experimental group (G1), consumption of RS was associated with reduction in HbA1c (P = 0·0001), fasting glucose (P = 0·021), diastolic blood pressure (P = 0·010), body weight (P = 0·002), BMI (P = 0·006), waist and hip circumferences (P < 0·01), fat mass percentage (P = 0·001) and increase in lean mass percentage (P = 0·011). In controls (G2), reductions were observed in waist and hip circumferences (P < 0·01), HbA1c (P = 0·002) and high-density lipoprotein-cholesterol (P = 0·020). In pre-diabetes or diabetes, non-significant differences were observed in the percentage reduction in HbA1c and fasting glucose in exploratory analyses. Our results indicate that the consumption of bioactive starches is a good dietary strategy to improve metabolic control and body composition.

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Section: Variablessupporting

confidence: 92%

Section: Variablesmentioning

confidence: 99%

Beneficial effects of green banana biomass consumption in patients with pre-diabetes and type 2 diabetes: a randomised controlled trial

et al. 2019

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“…Our results were in accordance with previous reports of Azad et al 50 who have shown an increase in myocardial malonyldialdehyde and a decrease in antioxidant enzyme activities after aluminium phosphide treatment. 58 Co-exposure to aluminum and acrylamide caused an important increase in the plasma TC and LDL-C levels and a decrease in HDL-C and TG, which indicated a change in the permeability of hepatic cells as reported in our previous study. This improvement was more pronounced in rats treated with EVOO than OOLF and OOHF used separately reflecting the synergic effect of the two fractions in order to restore the activities of anti-oxidant enzymes.…”

Section: Discussionsupporting

confidence: 82%

Effects of dietary extra virgin olive oil and its fractions on antioxidant status and DNA damage in the heart of rats co-exposed to aluminum and acrylamide

et al. 2015

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Oxidative stress generated by an excessive production of free radicals has been linked to the development of several health problems such as cardiovascular diseases. We investigated the protective efficacy of Extra Virgin Olive Oil (EVOO) and its lipophilic fraction (OOLF) and hydrophilic fraction (OOHF) against the cardiotoxicity and DNA damage induced by co-exposure to aluminum (AlCl3) and acrylamide (ACR). Rats were divided into eight groups of six each: controls, AlCl3 (50 mg per kg body weight) administered via drinking water and ACR (20 mg per kg body weight) given by gavage, combined group plus EVOO (300 μl); combined group plus the hydrophilic fraction (1 ml); combined group plus the lipophilic fraction (300 μl); extra virgin olive oil (EVOO) and its fractions were administered daily by gavage for 21 days. Three other groups, considered as positive controls, received either EVOO, OOLF or OOLH. Exposure of rats to both AlCl3 and ACR provoked oxidative stress objectified by an increase in MDA, AOPP and a decrease in GSH, NPSH and vitamin C levels. The activities of CAT, GPx and SOD were also decreased. EVOO and its OOLF fraction exhibited a pronounced enhancement of antioxidant status while a partial recovery in the antioxidant status was obtained with the OOHF fraction. Plasma LDH and CK activities, TC, LDL-C levels, TC/HDL-C and LDL-C/HDL-C ratios were increased, while HDL-C and TG decreased in rats treated with both AlCl3 and ACR. Co-administration of EVOO, OOLF or OOHF to treated rats restored cardiac biomarkers and lipid profile to near-normal values. Histological studies and DNA damage confirmed the biochemical parameters and the beneficial role of EVOO and its two fractions. Our results suggest that extra virgin olive oil and its two fractions can decrease the frequency of cardiac complications and genotoxicity.

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“…Although mean blood glucose levels were lowered with RS4 consumption, the differences did not approach statistical significance compared to the control. Mesa Garcia and her colleagues have taken a step ahead of research to study a new fructose-free DSF in fragile elderly T2DM patients for 6 wks and evaluate the influence of total enteral feeding on the glycemic control and diabetes-derived cardiovascular risk biomarkers ( 48 ). These new fructose-free DSF and RS4-enriched DSF formulations effectively controlled glycemic by decreasing blood HbA1c, and some improvements were documented in MCP-1, sE-selectin, and sVCAM-1 and PAI-1 plasma levels.…”

Section: Discussionmentioning

confidence: 99%

Effects of Resistant Starch Interventions on Metabolic Biomarkers in Pre-Diabetes and Diabetes Adults

et al. 2022

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Simple lifestyle changes can prevent or delay the onset of type 2 diabetes mellitus (T2DM). In addition to maintaining a physically active way of life, the diet has become one of the bases in managing TD2M. Due to many studies linking the ability of resistant starch (RS) to a substantial role in enhancing the nutritional quality of food and disease prevention, the challenge of incorporating RS into the diet and increasing its intake remains. Therefore, we conducted this review to assess the potential benefits of RS on metabolic biomarkers in pre-diabetes and diabetes adults based on available intervention studies over the last decade. Based on the conducted review, we observed that RS intake correlates directly to minimize possible effects through different mechanisms for better control of pre-diabetic and diabetic conditions. In most studies, significant changes were evident in the postprandial glucose and insulin incremental area under the curve (iAUC). Comparative evaluation of RS consumption and control groups also showed differences with inflammatory markers such as TNF-α, IL-1β, MCP-1, and E-selectin. Only RS2 and RS3 were extensively investigated and widely reported among the five reported RS types. However, a proper comparison and conclusion are deemed inappropriate considering the variations observed with the study duration, sample size, subjects and their metabolic conditions, intervention doses, and the intervention base products. In conclusion, this result provides interesting insights into the potential use of RS as part of a sustainable diet in diabetes management and should be further explored in terms of the mechanism involved.

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A new fructose-free, resistant-starch type IV-enriched enteral formula improves glycaemic control and cardiovascular risk biomarkers when administered for six weeks to elderly diabetic patients

Cited by 10 publications

References 30 publications

Beneficial effects of green banana biomass consumption in patients with pre-diabetes and type 2 diabetes: a randomised controlled trial

Beneficial effects of green banana biomass consumption in patients with pre-diabetes and type 2 diabetes: a randomised controlled trial

Effects of dietary extra virgin olive oil and its fractions on antioxidant status and DNA damage in the heart of rats co-exposed to aluminum and acrylamide

Effects of Resistant Starch Interventions on Metabolic Biomarkers in Pre-Diabetes and Diabetes Adults

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