A new far-red naphthorhodamine dye: Synthesis, fluorescent probe and bioimaging applications

Hybrid Rhodamine Fluorophores in the Visible/NIR Region for Biological Imaging

“…The group constructed am itochondria-specific fluorescent dye and fluorescent probe for Hg 2+ by esterification and acylation of the dye 188,respectively. [90] Utilizing hybridization of cyanine and rhodamine to construct cyanine-rhodamine dyes can produce compounds with emission wavelengths of over 720 nm. However,t he unique cyanine-rhodamine dyes retain the chemical structure of cyanine and are therefore still susceptible to structural degradation by conjugative addition of nucleophiles [91] or ROS.…”

An α-naphtholphthalein-derived colorimetric fluorescent chemoprobe for the portable and visualized monitoring of Hg2+by the hydrolysis mechanism

“…[30][31][32][33][34] Over the past few decades, a large number of small molecule fluorescent chemoprobes have been developed for Hg 2+ detection. [35][36][37][38][39][40] Nevertheless, fluorescent chemoprobes for specific detection of Hg 2+ through a hydrolysis mechanism have been emerging in recent years, [41][42][43][44][45] which is because one chemoprobe for Hg 2+ monitoring via a coordination mode easily suffers from not only the detection conditions but also the redox reactive species such as reactive sulfur species in vitro and in vivo. 46 Generally, it is of great necessity for environmental engineers to curb environmental pollution, especially water pollution, using the scrap metal packing filtration method; for instance, the Fe replacement reaction equation is as follows: Fe + Hg 2+ = Hgk + Fe 2+ , and thus the highly toxic heavy metal cation Hg 2+ -based pollution can be treated by the formation of the elemental Hg.…”

Synthesis, stability and spectral behavior of fluorogenic sulfone-pyronin and sulfone-rosamine dyes

“…To achieve sensitive and reliable fluorescence detection in complex biological systems or in living organisms, and thus considering biomedical applications for xanthene-based fluorophores, current research efforts are primarily devoted to the design of rhodamines and related compounds having absorption/emission maxima in the spectral range 650-900 nm [15], often called "therapeutic optical window" (or NIR-1 window) [16]. The relevant strategies implemented to achieve this goal can be classified into two main categories: (1) the extension of the p-conjugated system either through the introduction of various fused aromatic rings within the xanthene core [17][18][19][20][21][22][23][24][25][26][27][28][29][30] or the installation of a dimethine bridge connecting another chromophore unit (e.g., dihydroxanthene-hemicyanine fused dyes) [31,32], and (2) the replacement of the 10-position O atom of xanthene by a group 14 element (i.e., C, Si, or Ge) [33][34][35][36] or an oxidized-heteroatom such as B(OH) 2 [37], P(O)R [38,39], P(O)OR [40], or Te(O) [41]. This latter approach is particularly attractive because it produces dyes with significantly red-shifted absorption and fluorescence maxima, typically around or above 650 nm, and keeping compact structures and small molecular weights.…”