A new drug carrier: Magnetite nanoparticles coated with amphiphilic block copolymer

Chang, Yu‐Hsu; Bai, Yunpeng; Teng, Bao; Li, Zhaolong

doi:10.1007/s11434-009-0144-0

Cited by 15 publications

(9 citation statements)

References 22 publications

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“…In recent years, biological applications of magnetite nanoparticles increased dramatically, such as drug-targeting [4,5], magnetic resonance imaging (MRI) [6], magnetic separation [7], and hyperthermia treatment of cancer [8]. These applications all require molecular level understanding and control of the interface between biomolecules and magnetite nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…Currently chemical methods for preparing magnetite nanoparticles mainly follow two routes: (1) thermal decomposition of iron containing organometallic compounds [9][10][11][12][13] such as Fe(acac) 3 , Fe(oleate) 3 or Fe(CO) 5 in a high boiling-point organic solvent together with ligands such as oleic acid, and (2) co-precipitation of ferric and ferrous salts in aqueous solution at room or slightly higher temperature, using polymer or charged molecules as surfactants [14]. Magnetite nanoparticles synthesized by thermal decomposition are usually monodisperse in size and highly crystalline, but they are soluble only in nonpolar solvents.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and ξ-potential characterization of highly dispersible phosphate — functionalized magnetite nanoparticles

Xue-Yi

Tang

2011

Sci. China Phys. Mech. Astron.

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By the combination of high-temperature organometallic synthesis and phase transfer through complete ligand-exchange with mixed phosphate, highly water-dispersible Fe 3 O 4 nanoparticles with narrow size distribution are obtained, which show applicable response to magnetic field. IR and -potential characterization of this system provides insights into ligand structures on particle surface. magnetite, nanoparticle, ξ-potential, ligand-exchange PACS: 98.70.Sa, 90.50.sb, 13.85.Tp

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation and ξ-potential characterization of highly dispersible phosphate — functionalized magnetite nanoparticles

Xue-Yi

Tang

2011

Sci. China Phys. Mech. Astron.

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“…Surfactants or block copolymers were frequently employed to passivate the surface of the nanoparticles for increasing their stability and dispersity [6][7][8][9][10]. In general, surfactants or block copolymers were chemically anchored and physically adsorbed on the magnetic nanoparticles to form a single or double layer.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Fe3O4@SiO2@polymer nanoparticles for controlled drug release

Gao

et al. 2010

Sci. China Chem.

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Novel multifunctional nanoparticles containing a magnetic Fe 3 O 4 @SiO 2 sphere and a biocompatible block copolymer poly(ethylene glycol)-b-poly(aspartate) (PEG-b-PAsp) were prepared. The silica coated on the superparamagnetic core was able to achieve a magnetic dispersivity, as well as to protect Fe 3 O 4 against oxidation and acid corrosion. The PAsp block was grafted to the surface of Fe 3 O 4 @SiO 2 nanoparticles by amido bonds, and the PEG block formed the outermost shell. The anticancer agent doxorubicin (DOX) was loaded into the hybrid nanoparticles via an electrostatic interaction between DOX and PAsp. The release rate of DOX could be adjusted by the pH value. magnetic nanoparticle, Fe 3 O 4 @SiO 2 , multifunctional, controlled drug release

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“…Non-viral vectors have the advantages of safety and flexibility over viral vectors [1,2]. However, the transfection efficiencies of non-viral gene vectors are generally lower than those of viral vectors [3].…”

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confidence: 99%

Enhancement of the efficiency of PEI/liposome transfection by magnetofectins formed via electrostatic self-assembly

Wang

2012

Chin. Sci. Bull.

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One of the major challenges for successful gene therapy is improving the transfection efficiency of non-viral vectors. Magnetic nanoparticles (MNPs) have been developed as enhancers of non-viral vehicles. We prepared MNPs and modified them with polyethyleneimine (PEI), citric acid (CA) or carboxylmethyl-dextran (CMD). Both positively charged MNPs (MNPs@PEI) and negatively charged MNPs (MNPs@CA, MNPs@CMD) could spontaneously form transfection complexes (magnetofectins) with plasmid DNA and PEI/liposome via electrostatic self-assembly. Our results showed as-prepared magnetofectins apparently enhanced PEI/liposome transfection efficiency and/or gene expression level into COS-7 cells with reduced transfection time from 4 h to 15 min under a magnetic field in vitro. Meanwhile, the effect of magnetofection was cell line-dependant. These results suggest that charged MNPs could improve transfection efficiency for non-viral vectors by simply mixing with them and by exerting a magnetic force. Thus such MNPs provide a convenient platform for further applications of gene delivery. In order to combine MNPs with non-viral vectors, MNPs were coated with PEI [4,5] or cationic liposomes [6]. In fact, according to the mechanism study on magnetofection, MNPs play the role of driving vector/pDNA complexes to cell surface in magnetofection and do not directly affect the endocytic uptake mechanism [4]. Magnetofection requires MNPs to have sufficient electric potentials at the surface, so it is not necessary to modify MNPs with these gene vectors according to our previous study [7]. Our experimental evidences indicate that MNPs could not enter nucleus once they were internalized by the cells. MNPs would probably have to be separated from vector/pDNA complexes after entering cytoplasm, although detailed mechanism requires further investigation. In this study, we aim to further demonstrate charged MNPs, both positively charged and negatively charged MNPs, can improve transfection efficiency for non-viral vectors by simply mixing with them via electrostatic self-assembly.In this paper, we introduced the preparation, cytotoxicity of magnetofectins as prepared via electrostatic self-assembly, and evaluated the performance of these magnetofectins in magnetofection as follows: (1) to determine if MNPs@PEI can improve PEI reagent transfection; (2) to determine if negatively charged MNPs@CA and MNPs@CMD can improve PEI reagent transfection; (3) to determine if charged

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A new drug carrier: Magnetite nanoparticles coated with amphiphilic block copolymer

Cited by 15 publications

References 22 publications

Preparation and ξ-potential characterization of highly dispersible phosphate — functionalized magnetite nanoparticles

Preparation and ξ-potential characterization of highly dispersible phosphate — functionalized magnetite nanoparticles

Synthesis of Fe3O4@SiO2@polymer nanoparticles for controlled drug release

Enhancement of the efficiency of PEI/liposome transfection by magnetofectins formed via electrostatic self-assembly

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