A new dimeric neolignan from Magnolia grandiflora L. seeds

Li, Hongmei; Song, Zhao; Huo, Qiang; Ma, Tao; Líu, Hao; Lee, Jae kyoung; Hong, Young‐Soo; Wu, Cheng‐Zhu

doi:10.1007/s12272-014-0476-4

Cited by 10 publications

(9 citation statements)

References 14 publications

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“…Many in vitro and in vivo investigations offer evidence of the effectiveness of MAG against liver cancer where it is found to increase cell cytotoxicity, repress cell proliferation/cell viability and reduce tumor growth significantly [61,127,129,141,142,143]. MAG induced apoptosis in HepG2 cells by increasing the intracellular level of calcium along with increased translocation of cyt- c from mitochondria to the cytosol and activation of caspase-3, -8, and -9 [57].…”

Section: Effect Of Magnolol In Different Cancersmentioning

confidence: 99%

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Ranaware¹,

Banik

Deshpande³

et al. 2018

IJMS

134

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The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted. Several natural compounds have proved their potential against this dreadful disease so far. Magnolol is a hydroxylated biphenyl isolated from the root and stem bark of Magnolia tree. Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. Considering these perspectives, the current review primarily focuses on the fascinating role of magnolol against various types of cancers, and the source and chemistry of magnolol and the molecular mechanism underlying the targets of magnolol are discussed. This review proposes magnolol as a suitable candidate that can be appropriately designed and established into a potent anti-cancer drug.

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Section: Effect Of Magnolol In Different Cancersmentioning

confidence: 99%

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Ranaware¹,

Banik

Deshpande³

et al. 2018

IJMS

134

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“…Thus, the search for new anti-cancer agents from natural sources has gained importance in recent years. Bishonokiol A (BHNKA) is a dimeric neolignan isolated from Magnolia grandiflora seeds, and exhibits anti-proliferative activity, induces apoptosis, and inhibits invasion and migration of cancer cells (Figure 1A) (Li et al, 2015;Li et al, 2019). However, the pharmacological mechanism of BHNKA induced breast cancer cell death is still unclear.…”

Section: Bishonokiol a Induces Multiple Cell Death In Human Breast Cancer Mcf-7 Cellsmentioning

confidence: 99%

“…BHNKA was isolated from M. grandiflora, and the purity of BHNKA was higher than 96% by HPLC analysis (Li et al, 2015). Dulbecco's modified Eagle's medium (DMEM) and 0.25% trypsin were purchased from Hyclone (UT, USA).…”

Section: Reagents and Antibodiesmentioning

confidence: 99%

Bishonokiol A Induces Multiple Cell Death in Human Breast Cancer MCF-7 Cells

et al. 2020

Asian Pac J Cancer Prev

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Objective: A dimeric neolignan, bishonokiol A (BHNKA) isolated from Magnolia grandiflora , significantly inhibits the proliferation of human breast cancer cells. However, the exact mechanism of BHNKA induced breast cancer cell death is unknown. In this study, we investigated the pharmacological mechanism underlying BHNKA induced MCF-7 cell death. Methods: Cell viability measurement was performed by the MTT assay. Flow cytometry with PI staining, DAPI staining, and electron microscopy were used to analyze cellular death modes. In addition, western blotting, siRNA transfection, ATP assay, and fluorescence microscopy were used to determine the mechanism of BHNKA induced MCF-7 cell death. Results: BHNKA induced cell death by apoptosis, necroptosis and autophagy at the same concentration and time in MCF-7 cells, and electron microscopy confirmed these results. The mechanism of BHNKA triggered apoptosis and autophagy in MCF-7 cells was primarily due to an increase in the Bax/Bcl-2 ratio and simultaneous up-regulation of LC3-II protein expression, respectively. BHNKA induced necroptosis by activation of the RIP1-RIP3-MLKL necroptosis cascade, up-regulation of cyclophilin D (CypD) protein expression to stimulate ROS generation. We further demonstrated that siRNA-mediated down-regulation of CypD protected against BHNKA induced cell death. Conclusions: These results suggest that BHNKA may be a potential lead compound for development as an anti-breast cancer agent for induction of multiple cell death pathways.

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“…M. grandiflora has well‐known uses in American indigenous medicine as bitter tonics, antimalarials, and diaphoretics, [4] as well as in traditional Chinese medicine, in which the use of leaves for the treatment of hypertension has been reported [5] . Previous studies on M. grandiflora have led to the isolation and identification of various kinds of compounds, including alkaloids, [6] sesquiterpenoids, [7–9] sesquiterpene lactones, [10,11] flavonoids, [12] lignans [13] and neolignans [14–16] . Additionally, several studies have focused on the composition of volatile fractions and essential oils of different plant parts.…”

Section: Introductionmentioning

confidence: 99%

GC/MS‐Based Fingerprinting Reveals Two Chemotypes in the Leaf Essential Oils fromMagnolia grandifloraTrees within The Urban Forestry of a Colombian Andean Plateau

Bernal

Matulevich

Corredor

et al. 2022

Chemistry & Biodiversity

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Magnolia grandiflora is an aromatic plant widely distributed around the world. In Colombia, and more specifically in Bogotá, M. grandiflora has been introduced as part of urban forestry programs, and their specimens are therefore subjected to several environments. Nevertheless, there are no previous studies on the chemical composition of such plants. Hence, the characterization of the essential oil from 20 specimens of M. grandiflora from Bogotá, Colombia, by GC/MS was carried out here. Two different chemotypes were found. While one was characterized by monoterpenes α-pinene, β-pinene, and limonene, the other contained mainly sesquiterpenes βelemene, bicyclogermacrene, and germacrene D. Multivariate statistical analyses confirmed their existence and helped to identify variations within and between chemotypes. Furthermore, differential expression of genes encoding the terpene synthases Mg25 and Mg17 could arguably be responsible for the characteristic compositions of both chemotypes, as suggested by rational biosynthetic analysis of the most contrasting metabolites.

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A new dimeric neolignan from Magnolia grandiflora L. seeds

Cited by 10 publications

References 14 publications

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Bishonokiol A Induces Multiple Cell Death in Human Breast Cancer MCF-7 Cells

GC/MS‐Based Fingerprinting Reveals Two Chemotypes in the Leaf Essential Oils fromMagnolia grandifloraTrees within The Urban Forestry of a Colombian Andean Plateau

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