A New Cyproheptadine PVC Ion Selective Electrode and their Applications in Pharmaceutical Preparations and Human Fluids

Ismaeel, Yusur Q.; Al-Phalahy, Bashaer A.

doi:10.22401/anjs.23.2.04

Cited by 7 publications

(5 citation statements)

References 9 publications

(9 reference statements)

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“…The selectivity coefficient values for (SSM) were computed using the Nickolsky-Eisenman equation 19 and recorded in Table 2. 19 Fewer values of K A,B were obtained leads to no interfering of these inorganic cations on the sensor B response 20 . Figures 15-17 shows the results of selectivity by (MPM)…”

Section: Selectivitymentioning

confidence: 98%

Novel Potentiometric Sensor for Estimation of the Moxifloxacin in the Pharmaceutical Samples, Urine, and Serum

Abrahem¹,

Ahmad²,

Al-Phalahy³

2022

IJDDT

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An easy, simple and ecofriendly process for the estimation of moxifloxacin (MFN) in the pharmaceutical samples, serum and blood. The prepared sensors contained moxifloxacin–bromophenol blue as ionphore and, tris(2-ethylhexyl) phosphate, di-butyl phthalate and di-butyl phosphate as plasticizers. The electrodes based on di-n-butyl phthalate (DBPH), Tris (2-ethylhexyl) phosphate (TEHP), and di-butyl phosphate (DBP), gave slope 44.50, 56.86 and 46.38 mV/decade, respectively. The linear concentrations were 1×10-5 - 1×10-2, 5×10-5- 1×10-2 and 5×10-5 - 1×10-2 M with detection limits of 9.0×10-6, 4.7×10-5 and 4.9×10-5 M and a lifetime of 17, 39 and 12 days for electrodes based on DBPH, TEHP, and DBP, respectively. The best electrode was TEHP which gave the best results. The sensor that based on TEHP as plasticizer was better response and stability, it was used to estimate the moxifloxacin in pharmaceutical samples using single and multi-standard addition potentiometry.

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Section: Selectivitymentioning

confidence: 98%

Novel Potentiometric Sensor for Estimation of the Moxifloxacin in the Pharmaceutical Samples, Urine, and Serum

Abrahem¹,

Ahmad²,

Al-Phalahy³

2022

IJDDT

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show abstract

“…The obtained results have been compared and validated with that of liquid chromatography (LC), and non-significant differences were attained, indicating the validity of the proposed sensor for its usage. Ismaeel et al designed potentiometric sensors for the assay of cyproheptadine in tablet dosage form, human urine and plasma by employing di-butylphthalate (electrode 1), tris (2-ethylhexyl) phosphate (electrode 2) as well as o-NPOE (electrode 3) as plasticizers 26 . The three mentioned electrodes have a limit of detections of 9.0× 10 -5 , 7.5× 10 -5 , and 6.0× 10 -5 M for electrodes 1, 2, and 3, respectively.…”

Section: Application Of the Potentiometric Sensors For The Determination Of Pharmaceutical Drugsmentioning

confidence: 99%

Potentiometric sensors for the determination of pharmaceutical drugs

et al. 2022

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Potentiometric sensors based on ion-selective membrane electrodes have continued to get great attention from the scientific community. These sensors have been employed in several applications including medicine, forensic analysis, environmental assessment, industry, agriculture, and pharmaceutical drug analysis. Indeed these sensors possess several advantages for example simple design, fabrication, and manipulation, rapid response time, good selectivity, applicability to colored and turbid solutions, and possible interfacing with automated and computerized systems. On the other hand, therapeutic drug monitoring and detection of pharmaceutical drugs in their pharmaceutical formulations and biological matrices are highly significant from a medical point of view especially for drugs with a narrow therapeutic index such as anticancer drugs which can cause fatal side effects for patients. Interestingly, potentiometric sensors have been broadly employed as one of the most important electrochemical approaches for pharmaceutical drug analysis. Moreover, the breakthroughs in potentiometric sensors based on ion-selective electrodes (ISEs) make them superior to the other reported methods for pharmaceutical drug analysis in terms of many performance parameters such as sensitivity, selectivity, low detection limit, and low cost. In this review, we try to offer a summary prologue to the applicability and merits of the potentiometric sensors that have been employed for pharmaceutical drug analysis emphasizing their application for the assay of pharmaceutical drugs in their dosage forms and the in-vivo assay of pharmaceutical drugs in different biological samples such as milk, water, plasma, and urine.

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“…This could be because the normal work style, in comparison to the multi standard addition method, eliminates the dilution component during solution preparation. [19][20][21] As a result, errors are reduced.…”

Section: Cpf Application In Pharmaceutical Samples and Human Fluidsmentioning

confidence: 99%

New Carbon Paste Sensor for the Determination of Ciprofloxacin in the Pharmaceutical Preparations, Serum and Urine

Khalaf¹,

Al-Aphalahy²

2022

IJDDT

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A quick, novel and highly accurate sensor with superior electrochemical properties have been developed to measure ciprofloxacin in pharmaceutical preparations and human fluids. Three carbon paste sensors for ciprofloxacin (CPF) were produced using the ionophore molecule ciprofloxacin-methyl orange (CPF-MO) in combination with three different plasticizers: di-butyl phthalate (DBPH), di-butyl phosphate (DBP), and tris (2-ethylhexyl)phosphate (TEHP). The slopes of sensors A, B, and C were 59.84, 44.67, and 50.49 mV/decade, respectively. The linear range was 5× 10-5 to 1 ×10-2 M, with detection limits of 4.6×10-5, 4.4×10-5, and 4.9×10-5 M, respectively, and a lifetime of 58, 19, and 21 days. Because sensor A produces the best results, pharmaceutical and human fluids were applied using this sensor; the recovery percentages were 98, 97, 102, 95, and 97 for CPF standard, Bactiflox tablets 500 mg, ciprocin eye drop 0.3%, urine, and serum, respectively, using potential techniques.

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A New Cyproheptadine PVC Ion Selective Electrode and their Applications in Pharmaceutical Preparations and Human Fluids

Cited by 7 publications

References 9 publications

Novel Potentiometric Sensor for Estimation of the Moxifloxacin in the Pharmaceutical Samples, Urine, and Serum

Novel Potentiometric Sensor for Estimation of the Moxifloxacin in the Pharmaceutical Samples, Urine, and Serum

Potentiometric sensors for the determination of pharmaceutical drugs

New Carbon Paste Sensor for the Determination of Ciprofloxacin in the Pharmaceutical Preparations, Serum and Urine

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