"A New Cutaneous Manifestation in the Syndrome of Vitamin a Deficiency"

Loewenthal, L. J. A.

doi:10.1001/archderm.1934.01460100121014

Cited by 7 publications

(8 citation statements)

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“…This is the first reported case of cutaneous spicules occurring in an ethnic Chinese female with progressive multiple myeloma. Cutaneous spicules of varying pathogenesis have been reported under different nomenclature, common associations include chronic renal failure, 9,10 Crohn’s disease, 11 hypovitaminosis A, 12 HIV infection, 13 lymphoma, 14 and other malignancies 15–17…”

Section: Discussionmentioning

confidence: 99%

Cutaneous follicular hyperkeratotic spicules – the first clinical sign of multiple myeloma progression or relapse

Tay

Lim

et al. 2010

Int J Dermatology

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Section: Discussionmentioning

confidence: 99%

Cutaneous follicular hyperkeratotic spicules – the first clinical sign of multiple myeloma progression or relapse

Tay

Lim

et al. 2010

Int J Dermatology

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“…In the early 1930s, a follicular eruption attributed to vitamin A deficiency was described in Chinese patients by Frazier and Hu 39 , 40 . Loewenthal 41 reported a similar papular eruption in Ugandan prisoners diagnosed with vitamin A deficiency, and noted a histology identical to the papules of PRP. This finding led to speculation that PRP might result from a vitamin A deficiency and prompted early successful attempts at treatment with vitamin A; 42–44 however, patients with PRP frequently have normal serum vitamin A levels.…”

Section: Etiology and Associated Conditionsmentioning

confidence: 95%

Pityriasis rubra pilaris

1999

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“…To date, the exact aetiology and pathogenesis of PRP are still unknown. In the past, vitamin A deficiency was postulated as one of the causes of PRP . Meanwhile, the understanding is that PRP is not a consequence of vitamin A deficiency, but rather it is responsive to alitretinoin, isotretinoin etretinate, and vitamin A .…”

Section: Aetiology and Pathologymentioning

confidence: 99%

Pityriasis rubra pilaris: algorithms for diagnosis and treatment

Roenneberg

Biedermann

2018

Acad Dermatol Venereol

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Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disease that affects men and women of all ages and also children. The clinical appearance of PRP is highly variable, as is the individual prognosis. Therefore, stratifying PRP into six disease subtypes represents a first step to personalized medicine for this rare inflammatory skin disease. The next step should be to associate specific therapeutic strategies with these subtypes of PRP. However, no randomized, controlled trials on the treatment of PRP have been performed. Consequently, the actual treatment algorithm for PRP will be based on clinical experience, small case series and case reports. The majority of published evidence is on type I PRP, whereas the treatment experience for other clinical types of PRP is still sparse and has to be gained. Nevertheless, it is now time to start developing valid algorithms as a basis for the diagnosis and treatment of PRP based on the data available. This review makes use of algorithms developed in psoriasis and atopic eczema and puts together recent insights into the pathogenesis, diagnosis and treatment experience of PRP. The innovative intention of this appraisal is to develop a structured algorithm for PRP treatment that should be further developed going forward.

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"A New Cutaneous Manifestation in the Syndrome of Vitamin a Deficiency"

Cited by 7 publications

References 0 publications

Cutaneous follicular hyperkeratotic spicules – the first clinical sign of multiple myeloma progression or relapse

Cutaneous follicular hyperkeratotic spicules – the first clinical sign of multiple myeloma progression or relapse

Pityriasis rubra pilaris

Pityriasis rubra pilaris: algorithms for diagnosis and treatment

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