Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2011.12.082 View full text
Regina M.B.O. Duarte, João T.V. Matos, Armando C. Duarte

Abstract: A new chromatographic response function (CRF(2D)) is proposed and tested for the estimation of the quality index of separation in comprehensive two-dimensional liquid chromatography (2D-LC) of complex organic mixtures. This objective function is based on the concept of peak purity for one-dimensional liquid chromatography, which has been redefined for 2D-LC. The new CRF(2D) also includes other separation quality criteria, namely the number of 2D peaks appearing in the chromatogram and the analysis time. To com…

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