A new chalcone from the aerial roots of Ficus microcarpa

PREPARATIVE ISOLATION AND PURIFICATION OF FLAVONE C-GLYCOSIDES FROM THE LEAVES OF FICUS MICROCARPA L.f BY MEDIUM-PRESSURE LIQUID CHROMATOGRAPHY, HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY, AND PREPARATIVE LIQUID CHROMATOGRAPHY

“…Due to its various pharmaceutical effects such as clearing heat, detoxifying, diminishing swelling, removing dampness and relieving pain, Ficus microcarpa L.f has been used widely for the treatment of chronic bronchitis, influenza whooping cough, tonsillitis, toothache, bacillary dysentery, enteritis, bruises[1]. Many triterpenoids[2-11], phenolic compounds[12], isoflavones[13-15] and flavones[17,19] have been isolated from aerial roots, bark, leaves and fruits of Ficus microcarpa L.f.…”

“…Separation and purification of chemical constituents from Ficus microcarpa L.f by the classical methods requires multiple chromatographic steps using silica gel, polyamide column [3-15, 17, 19], in which a large amount of using organic solvents are unfriendly to our environment and these conventional separation methods are tedious, time consuming, and have the peril of loss of sample due to the highly adsorptive effect onto the solid matrix. Therefore more efficient separation methods need to be explored further.…”

Botany, Uses, Chemistry and Pharmacology of Ficus microcarpa: A Short Review

“…25 In China, F. microcarpa (rong shu) is commonly planted as a shade tree, 3 and has been used to treat flu, malaria, acute enteritis, tonsillitis, bronchitis and rheumatism. 26 The Okinawan soba is a famous noodle made by kneading wheat with the lye of wood ash. The wood ash of F. microcarpa yields noodles of high quality.…”

“…45 4-(2-Methylbut-3-en-2-yl)-4'-methoxy-2,5-dihydroxychalcone, a new chalcone from aerial roots of F. microcarpa exhibited weak cytotoxicity against K562 and PC3 human cancer cell lines. 26 Plectranthoic acid (Figure 4), a pentacyclic terpenoid isolated from the aerial roots of F. microcarpa was recently reported to possess potent 5' AMP-activated kinase (AMPK) activating properties, far superior than metformin. 27 Treatment with plectranthoic acid inhibited proliferation of prostate cancer cells, promoted G0/G1 phase cell cycle arrest, and induced apoptosis in the cancer cells in an Ficusolide diacetate* Heartwood [38] Ficuspirolide* Heartwood [28] Ficusolide* Heartwood [28] Lignans Ficusal* Heartwood [38] Fiscusesquilignans A, B* Heartwood [38] Megastigmanes Bridelionoside B Leaf [33] Dihydroalangionoside A Leaf [33] Ficumegasoside* Leaf [33] (3S,5R,6R,7E,9S)-Megastigman-7-ene-3,5,6,9-tetraol Leaf [33] Monoterpenoid Ficusic acid Heartwood [35] Phenylpropanoids (7E,9Z)-Dihydrophaseic acid 3-O-β-D-glucopyranoside* Aerial root [39] 2,2'-Dihydroxyl ether Aerial root [39] Erythro-guaiacylglycerol Aerial root [40] Erythro-guaiacylglycerol 9-O-β-D-glucopyranoside* Aerial root [40] Ficuscarpanic acid* Aerial root [39] Ficuscarpanosides A, B* Aerial root [39,40] Icariside D2 Aerial root [39] Guaiacylglycerol Aerial root [40] Guaiacylglycerol 9-O-β-D-glucopyranoside* Aerial root [40] 3-(4-Hydroxy-3-methoxy phenyl) propan-1,2-diol Aerial root [40] 4-Methoxy guaiacylglycerol-7-O-β-D-glucopyranoside Aerial root [40] Syringin Leaf [33] (7S,8R)-Syringoylglycerol Aerial root [39] (7S,8R)-Syringoylglycerol-7-O-β-D-glucopyranoside Aerial root [39] Phenolic acids Catechol Bark, aerial root [25,41] Coumaran Bark [25] Coumaric acid Leaf, aerial roo...…”

Design and Synthesis of a Fluorescent Probe with a Large Stokes Shift for Detecting Thiophenols and Its Application in Water Samples and Living Cells

“…The biological activities of chalcone derivatives are well known [28,29,30,31,32,33]. These derivatives also exhibit some excellent optical properties.…”