A new Borrelia species isolated from patients with relapsing fever in Spain

Anda, Pedro; Sánchez-Yebra, Waldo; Vitutia, Maria del Mar; Pastrana, E. Perez; Rodríguez, Isabel; Miller, Nancy S.; Backenson, P. Bryon; Benach, Jorge L.

doi:10.1016/s0140-6736(96)02332-x

Cited by 78 publications

(57 citation statements)

References 15 publications

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“…The latter study also demonstrated that CNS infection was serotype-specific (37). Another murine model using a blood isolate from a patient with relapsing fever (38) showed that meningitis developed shortly after the third peak of spirochetemia (39). This model, as is the case with other murine models of relapsing fever, closely resembles the human infection (1,3).…”

mentioning

confidence: 65%

The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis

Gebbia¹,

Moncó²,

Degen³

et al. 1999

J. Clin. Invest.

103

106

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confidence: 65%

The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis

Gebbia¹,

Moncó²,

Degen³

et al. 1999

J. Clin. Invest.

103

106

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“…Tick-borne relapsing fever (TBRF) is a zoonotic disease, caused by spirochetes of the genus Borrelia and transmitted to humans through the bite of soft ticks of the genus Ornithodoros, family Argasidae (Rebaudet & Parola, 2006 (Anda et al, 1996) (Fig. 3).…”

Section: Relapsing Fever Borreliosismentioning

confidence: 99%

Update on tick-borne bacterial diseases in Europe

et al. 2009

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Summary :In recent years, the prevalence of tick-borne bacterial diseases has significantly increased in European countries. The emergence and reemergence of these illnesses are attributed to changes in the environment and human behavior. Several diseases are caused by bacteria initially isolated from ticks and subsequently considered pathogenic. It is necessary to consider the bacteria found in arthropods capable of biting humans as potential human pathogens. Here we review the clinical and epidemiological data on bacterial tick-borne diseases in European countries. We focus on the epidemiological and clinical aspects of tick-borne rickettsioses and give an overview of other tick-borne illnesses as well as the emergence and re-emergence of these diseases. Résumé : ACTUALITÉ SUR LES MALADIES BACTÉRIENNES TRANSMISES PAR

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“…burgdorferi immunoglobulin, both the IFT and the ELISA produce false-positive results not only in healthy persons, due to saprophytic spirochetes and other bacteria with common antigenicity to B. burgdorferi inducing cross-reacting antibodies, but also in patients with autoimmune diseases, infectious mononucleosis, endemic recurrent fever, and other diseases caused by spirochetes [16,[19][20][21][22]. Confirmation of positive test results by other methods (immunoblot, isolation and culturing of B. burgdorferi, or DNA detection by PCR) should, therefore, be obtained and is generally recommended [17,23].…”

Section: Discussionmentioning

confidence: 99%

“…Saprophytic spirochetes and other bacteria having common antigenicity with B. burgdorferi may be responsible for these high antibody titres [15]. Additionally, cross-reactions with the bacteria responsible for the endemic recurrent fever have been described [16]. To…”

Section: Methodsmentioning

confidence: 99%

Anti-Borrelia burgdorferi immunoglobulin seroprevalence in pulmonary sarcoidosis: a negative report

Martens¹,

Zöllner²,

Zissel³

et al. 1997

Eur Respir J

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The aetiology of sarcoidosis is still unknown. An infectious microorganism as causal agent for this disease could not be identified, but high titres of antibodies against Borrelia burgdorferi were detected in Chinese studies implying a causality with this disease. These findings, however, could not be reproduced by other researchers. The aim of this study was, therefore, to evaluate the possible role of these spirochetes in the pathogenesis of sarcoidosis by serological examinations.Sixty sera of patients suffering from sarcoidosis were examined for anti-B. burgdorferi immunoglobulin by enzyme-linked immunosorbent assay (ELISA). ELISAs for these antibodies show a high sensitivity, but a low specificity; therefore, a specific immunoblot was used to confirm positive results.Initially, 8% of the patients were reactive in the ELISA, and 20% of these could be confirmed by immunoblot. Therefore, the prevalence for B. burgdorferi antibodies in sarcoidosis patients was 1.6%. This result did not differ significantly from the prevalence of B. burgdorferi antibodies in 1,000 regular blood donors of the city of Hamburg (7% reactive in the ELISA, 38% confirmed via immunoblot, prevalence 2.7%).The hypothesis of causality between a B. burgdorferi infection and sarcoidosis cannot be confirmed by this data.

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A new Borrelia species isolated from patients with relapsing fever in Spain

Cited by 78 publications

References 15 publications

The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis

The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis

Update on tick-borne bacterial diseases in Europe

Anti-Borrelia burgdorferi immunoglobulin seroprevalence in pulmonary sarcoidosis: a negative report

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