A new approach for trace analysis of guanidine compounds in surface water with resorcinarene-based ion chromatography columns

Panahi, Tayyebeh; Weaver, D. L.; Lamb, John D.; Harrison, Roger G.

doi:10.1039/c5an01076d

Cited by 9 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The column was prepared by a similar procedure to previously reported columns [34]. To prepare the column, 0.14 g of RUE was dissolved in 25 ml THF and polystyrene packing resin (1.60 g) was added to the solution and mixed well.…”

Section: Methodsmentioning

confidence: 99%

Separation of perfluoroalkyl substances by ion chromatography with a resorcinarene stationary phase

Chan

Harrison

2022

Separation Science Plus

Self Cite

View full text Add to dashboard Cite

Perfluoroalkyl substances pose a worldwide environmental health risk. It is important to develop new detection and quantification methods for perfluoroalkyl substances. Currently, liquid chromatography‐tandem mass spectrometry is the proposed method to analyze perfluoroalkyl substances. Ion chromatography, with its ability to use water samples as they are collected, could be a promising technique to detect anionic perfluoroalkyl substances in water. A new cationic stationary phase, composed of a resorcinarene bound to arginine, was synthesized and used to separate perfluoroalkyl substances by ion chromatography. The new packing material under the right gradient conditions separates perfluoroalkyl substances such as perfluorobutanoic acid, perfluorobutanesulfonic acid, perfluoropentanoic acid, perfluorohexanoic acid, perfluorohexanesulfonic acid, and perfluorooctanoic acid. Unlike the case with common anions, it was found that decreasing the NaOH concentration in the eluent resulted in better perfluoroalkyl substances separation. The detection limits of the perfluoroalkyl substances were from 0.44 to 4.0 mg/L and the limits of quantification were from 1.5 to 13 mg/L. The retention times of the perfluoroalkyl substances were dependent on the number of CF2 groups and whether their acid group was sulfonate or carboxylate. Also, the detection of perfluoroalkyl substances in tap and lake water was accomplished.

show abstract

Section: Methodsmentioning

confidence: 99%

Separation of perfluoroalkyl substances by ion chromatography with a resorcinarene stationary phase

Chan

Harrison

2022

Separation Science Plus

Self Cite

View full text Add to dashboard Cite

show abstract

“…Resorcinarenes, closely related to the largely exploited calixarenes, represent a unique class of polyphenol macrocycles, which have potential use in supramolecular chemistry, catalysis, and separation science . An acid‐catalyzed condensation reaction between resorcinol and aldehyde gives a cyclic oligomer of C‐alkylresorcin[4]arene.…”

Section: Introductionmentioning

confidence: 99%

Multifaceted Supramolecular Interactions from C‐Methylresorcin[4]arene Lead to an Enhancement in In Vitro Antibacterial Activity of Gatifloxacin

Dawn

Chandra

Ade-Browne

et al. 2017

Chemistry A European J

View full text Add to dashboard Cite

Mimicking the antibacterial activity of polyphenols in synthetic systems is an attractive approach for the development of new active pharmaceutical ingredients. Resorcinarenes represent a class of polyphenols, which have been exploited for decades for their attractive chemical scaffold suitable for forming host-guest complexes with hydrophobic guest molecules. However, the polyphenolic character of resorcinarenes, which could be a potential asset to the pharmaceutical industry, have been least exploited. The present work represents an unprecedented interplay of antimicrobial activity of resorcinarene together with its ability to interact chemically with an antibacterial drug gatifloxacin, improving the overall antibacterial activity. The chemistry and the clinical activities involved in this study were investigated simultaneously by spectroscopic techniques, as well as by in vitro measurement of antibacterial activity toward two human bacterial pathogens, a Gram-positive pathogen Staphylococcus aureus and a Gram-negative lung pathogen Legionella pneumophila. The initial positive result obtained from this study could revolutionize the use of synthetically modifiable resorcinarenes and their analogues in fine tuning the clinical behavior of drugs.

show abstract

“…However, the pathways toward guanidine accumulation and utilization in bacteria are still largely unknown. Beyond its biological importance, guanidine and its close derivatives are found as environmental pollutants or evidence of explosives. , As a contaminant, guanidine has been detected through spectroscopic methods such as UV and HPLC but these only work for in vitro samples. , Therefore, the development of a guanidine biosensor that can work both in the cell-free and cellular context will be significant for both environmental and biological applications.…”

mentioning

confidence: 99%

Guanidine Biosensors Enable Comparison of Cellular Turn-on Kinetics of Riboswitch-Based Biosensor and Reporter

2021

View full text Add to dashboard Cite

Cell-based sensors are useful for many synthetic biology applications, including regulatory circuits, metabolic engineering, and diagnostics. While considerable research efforts have been made toward recognizing new target ligands and increasing sensitivity, the analysis and optimization of turn-on kinetics is often neglected. For example, to our knowledge there has been no systematic study that compared the performance of a riboswitch-based biosensor versus reporter for the same ligand. In this study, we show the development of RNA-based fluorescent (RBF) biosensors for guanidine, a common chaotropic agent that is a precursor to both fertilizer and explosive compounds. Guanidine is cell permeable and nontoxic to E. coli at millimolar concentrations, which in contrast to prior studies enabled direct activation of the riboswitch-based biosensor and corresponding reporter with ligand addition to cells. Our results reveal that the biosensors activate fluorescence in the cell within 4 min of guanidine treatment, which is at least 15 times faster than a reporter derived from the same riboswitch, and this rapid sensing activity is maintained for up to 1.6 weeks. Together, this study describes the design of two new biosensor topologies and showcases the advantages of RBF biosensors for monitoring dynamic processes in cell biology, biotechnology, and synthetic biology.

show abstract

A new approach for trace analysis of guanidine compounds in surface water with resorcinarene-based ion chromatography columns

Cited by 9 publications

References 41 publications

Separation of perfluoroalkyl substances by ion chromatography with a resorcinarene stationary phase

Separation of perfluoroalkyl substances by ion chromatography with a resorcinarene stationary phase

Multifaceted Supramolecular Interactions from C‐Methylresorcin[4]arene Lead to an Enhancement in In Vitro Antibacterial Activity of Gatifloxacin

Guanidine Biosensors Enable Comparison of Cellular Turn-on Kinetics of Riboswitch-Based Biosensor and Reporter

Contact Info

Product

Resources

About