A new approach for simultaneously improved osseointegration and antibacterial activity by electrochemical deposition of graphene nanolayers over titania nanotubes

Rahnamaee, Seyed Yahya; Bagheri, Reza; Vossoughi, M.; Khafaji, Mona; Asadian, Elham; Seyedkhani, Shahab Ahmadi; Samadikuchaksaraei, Alí

doi:10.1016/j.apsusc.2021.152263

Cited by 18 publications

(23 citation statements)

References 48 publications

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“…The studies included in this systematic review applied graphene treatment to several materials such as yttria-stabilized tetragonal zirconia, [10] , [11] zirconia, [34] PEEK [26] , [35] , PMMA [36] , pure titanium [29] , [37] , [38] , [39] , [40] , [41] , [42] , [43] and titanium alloys [44] , [45] .…”

Section: Resultsmentioning

confidence: 99%

Osseointegration, antimicrobial capacity and cytotoxicity of implant materials coated with graphene compounds: A systematic review

Silveira,

Sahm,

Kreve

et al. 2023

Japanese Dental Science Review

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Section: Resultsmentioning

confidence: 99%

Osseointegration, antimicrobial capacity and cytotoxicity of implant materials coated with graphene compounds: A systematic review

Silveira,

Sahm,

Kreve

et al. 2023

Japanese Dental Science Review

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“…By manipulating or functionalizing graphene, some modified structures such as graphene oxide (GO), reduced graphene oxide (rGO), graphene fibers and other derivatives can be produced, which brings more choices for bionanotechnology [35,36]. Graphene can be coated on the electrodes using different methods such as chemical vapor deposition (CVD) [37], spraying [38], and electrochemical routes such as cyclic voltammetry (CV) [39]. However, weak adhesion of the graphene to the substrate, resulting in coating instability and destruction of the electrode, is one of the main challenges of the graphene electrodes.…”

Section: • Graphene Electrodesmentioning

confidence: 99%

Perspective Chapter: Tissue-Electronics Interfaces

Seyedkhani¹,

Mohammadpour²

2023

Biocomposites - Recent Advances

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Tissue-electronics interfaces provide a two-way communication between biological tissue and external electronics devices to record electrophysiological signals and stimulation of the living organs. This Chapter presents an overview of significant progresses in tissue-electronics interfaces. At first, we evaluate principal properties of the living tissue microenvironment important for tissue-specific equipment design. Next, we study charge transfer mechanisms in the biological tissues, bulk electrode materials, and tissue-electronics interfaces. After that, we highlight the current developing and promising advanced biomaterials for the neural electrodes, significantly leading to the development of bionanoelectronics and bionic organs. Finally, the challenges and future outlook of the neural interfaces will be discussed.

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“…It is rarely possible to ensure proper osteointegration of the implant while maintaining high bactericidal properties 2 as the most often modified surface layers or deposited coatings scarcely promote apatite formation in contact with bone-forming cells, exhibit weak adhesion to metallic substrates, and release antimicrobial substances in an uncontrolled manner, resulting in the burst release phenomena. 3 The hope might be coatings based on so-called intelligent (smart) biopolymers, which show a response to the changing effects of the external environment by altering their properties. The extrinsic stimulus may be a change in pH value, temperature, UV-visible radiation, electrical conductivity, and magnetic field intensity.…”

Section: Introductionmentioning

confidence: 99%

“…The bare metal implant shows poor bioactivity and antimicrobial properties. It is rarely possible to ensure proper osteointegration of the implant while maintaining high bactericidal properties 2 as the most often modified surface layers or deposited coatings scarcely promote apatite formation in contact with bone‐forming cells, exhibit weak adhesion to metallic substrates, and release antimicrobial substances in an uncontrolled manner, resulting in the burst release phenomena 3 …”

Section: Introductionmentioning

confidence: 99%

Cytocompatibility, antibacterial, and corrosion properties of chitosan/polymethacrylates and chitosan/poly(4‐vinylpyridine) smart coatings, electrophoretically deposited on nanosilver‐decorated titania nanotubes

Pawłowski,

Bartmański,

Ronowska

et al. 2023

J Biomed Mater Res

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The development of novel implants subjected to surface modification to achieve high osteointegration properties at simultaneous antimicrobial activity is a highly current problem. This study involved different surface treatments of titanium surface, mainly by electrochemical oxidation to produce a nanotubular oxide layer (TNTs), a subsequent electrochemical reduction of silver nitrate and decoration of a nanotubular surface with silver nanoparticles (AgNPs), and finally electrophoretic deposition (EPD) of a composite of chitosan (CS) and either polymethacrylate‐based copolymer Eudragit E 100 (EE100) or poly(4‐vinylpyridine) (P4VP) coating. The effects of each stage of this multi‐step modification were examined in terms of morphology, roughness, wettability, corrosion resistance, coating‐substrate adhesion, antibacterial properties, and osteoblast cell adhesion and proliferation. The results showed that the titanium surface formed nanotubes (inner diameter of 97 ± 12 nm, length of 342 ± 36 nm) subsequently covered with silver nanoparticles (with a diameter of 88 ± 8 nm). Further, the silver‐decorated nanotubes were tightly coated with biopolymer films. Most of the applied modifications increased both the roughness and the surface contact angle of the samples. The deposition of biopolymer coatings resulted in reduced burst release of silver. The coated samples revealed potent antimicrobial activity against both Gram‐positive and Gram‐negative bacteria. Total elimination (99.9%) of E. coli was recorded for a sample with CS/P4VP coating. Cytotoxicity results using hFOB 1.19, a human osteoblast cell line, showed that after 3 days the tested modifications did not affect the cellular growth according to the titanium control. The proposed innovative multilayer antibacterial coatings can be successful for titanium implants as effective postoperative anti‐inflammation protection.

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A new approach for simultaneously improved osseointegration and antibacterial activity by electrochemical deposition of graphene nanolayers over titania nanotubes

Cited by 18 publications

References 48 publications

Osseointegration, antimicrobial capacity and cytotoxicity of implant materials coated with graphene compounds: A systematic review

Osseointegration, antimicrobial capacity and cytotoxicity of implant materials coated with graphene compounds: A systematic review

Perspective Chapter: Tissue-Electronics Interfaces

Cytocompatibility, antibacterial, and corrosion properties of chitosan/polymethacrylates and chitosan/poly(4‐vinylpyridine) smart coatings, electrophoretically deposited on nanosilver‐decorated titania nanotubes

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