The principle of accelerator mass spectrometry (AMS) and its use in analyses of radioisotopes are described. AMS was developed during the latter half of the 1970s. Thereafter, it has been used mainly for microanalyses of long half‐life radioisotopes (
14
C,
10
Be,
26
Al,
36
Cl,
41
Ca,
129
I, etc.). The AMS finds widespread applications in many research fields, such as nuclear physics, space and earth sciences, medical science, biology, the science of agriculture, materials science, archaeology, and the science of cultural properties.