A new 5,6-dihydro-2-pyrone derivative from Phomopsis amygdali, an endophytic fungus isolated from hazelnut (Corylus avellana)

Diversity, distribution and biotechnological potential of endophytic fungi

“…Many bioactive substances are potentially useful to modern medicine, including cryptocin, gentiopicrin, spiroquinazoline alkaloids, taxol, vinblastine, vincristine, and so on (Stierle et al 1993;Li et al 2000;Barros and Rodrigues-Filho 2005;Yin et al 2009;Soliman et al 2013). Several recently reported novel bioactive secondary metabolites produced by fungal endophytes (Asai et al 2013;Xu et al 2013;Akay et al 2014;Xiao et al 2014;Zhang et al 2014a, b;Zhou et al 2014a, b) are presented in Fig. 1.…”

“…The reported compounds belong to diverse structural groups: alkaloids, benzofuran, cyclohexanone, dihydroisocoumarin, flavonoids, lipoids, organic acids, peptides, phenylpropanoids, pyridines, quinone, steroids, and terpenoids. Most novel substances showed antimicrobial, anti-insect, antioxidant, anticancer and antineoplastic activities, cytotoxicity, and other important biological functions (Kharwar et al 2011a;Sun et al 2011;Akay et al 2014;Xiao et al 2014;Zhou et al 2014a, b). The screening of novel bioactive secondary metabolites from endophytic fungi has become a research hotspot for new drug discovery and development.…”

“…They exhibit the abilities of protecting plants against various soil-borne pathogens, including Aspergillus fumigatus, Botrytis cinerea, Blumeria graminis, Fusarium culmorum, F. oxysporum, Globisporangium ultimum, Monilinia laxa, Moniliophthora perniciosa, Penicillium expansum, Phytophthora sp., P. palmivora, Plasmopara viticola, Puccinia polygoni-amphibii, Sclerotinia sclerotiorum Fig. 1 Structures of compounds 1-12, representing several novel bioactive secondary metabolites isolated from fungal endophytes (Asai et al 2013;Xu et al 2013;Akay et al 2014;Xiao et al 2014;Zhang et al 2014a, b;Zhou et al 2014a, b) and Verticillium longisporum (Arnold and Herre 2003;Waller et al 2005;Kim et al 2007;Chen et al 2010;Hanada et al 2010;Kurose et al 2012;Zhang et al 2014c). Endophytic fungi and their role as BCA have been partly discussed (Backman and Sikora 2008).…”

Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A Review

“…Compound 76 presented good activity against MDA-MB-231 (IC 50 : 24.26 μg/mL) and moderate activity against PC-3 and HT-29 (132.23 and 82.18 μg/mL, respectively). On the other hand, pestalotin showed good cytotoxic activity against the PC-3, HT-29, and MDA-MB-231 cell lines with IC 50 of 20.54, 16.69, and 41.70 μg/mL respectively (Akay et al, 2014 ). In the same study, authors investigated the presence of gene region of taxadiene synthase (a key enzyme in taxol biosynthesis) in the Phomopsis amygdali isolate using PCR.…”

Antimicrobial assay of endophytic fungi from Rumex madaio and chemical study of strain R1

“…Endophytes can dwell in almost all vascular plants (Zheng et al, 2016). Several evidences indicate that endophytic fungi are a species of abundant sources of natural products with diverse chemical structures and bioactivities, such as antimicrobial effect, anti-insect, antioxidant, anti-cancer, antineoplastic, cytotoxic, and so on (Akay et al, 2014;Zhou et al, 2014a;Zhou et al, 2014b;Li et al, 2015;Wang et al, 2016;Liu et al, 2017;Rani et al, 2017;Dhankhar et al, 2013). Moreover, endophytic microbes have the potential capability to produce the same and/or similar bioactive chemicals which are originally detected in their hosts, such as camptothecin, diosgenin, ginkgolide B, huperzine A, hypericin, podophyllotoxin, taxol, vinblastine, and vincristine (Zhang et al, 2014a).…”