A National Agenda for Research on Aging

Lonergan, Edmund T.; Krevans, Julius R.

doi:10.1056/nejm199106203242527

Cited by 58 publications

(32 citation statements)

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“…How interventions do this is expressed indirectly through their effects on other outcomes. Thus, log ðodds½W400ðt k Þ ¼ 1Þ ¼ w 0 þ w 1 where ''E'' refers to the expected value and intervention effects are modeled as influencing the mean of X ik (t k ). The slopes (w 1, m 1 , s 1 , and d 1 ) in these relationships are reported in Table 4 in standard deviation units to express, using a common yardstick, the degree to which changes in individual outcomes are associated with changes in X.…”

Section: Appendixmentioning

confidence: 99%

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Designing Clinical Trials of Interventions for Mobility Disability: Results From the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Trial

Espeland

Gill²,

Guralnik³

et al. 2007

The Journals of Gerontology Series A: Biological Sciences and M

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Section: Appendixmentioning

confidence: 99%

“…A S the life expectancy of older Americans increases, prevention of age-associated physical function decline and disabilities has emerged as a major clinical and public health priority (1). A critical factor in an older person's ability to function independently is mobility, the ability to move without assistance (2).…”

mentioning

confidence: 99%

Designing Clinical Trials of Interventions for Mobility Disability: Results From the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Trial

Espeland

Gill²,

Guralnik³

et al. 2007

The Journals of Gerontology Series A: Biological Sciences and M

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“…So that we could ascertain that these were first prescriptions for the treatment of glaucoma, study subjects were also required to have at least 4 months of continuous Medicaid eligibility preceding their first prescription for a glaucoma medication. Furthermore, we required that subjects demonstrate activity in the health care system by having filled at least one prescription for any nonglaucoma medication during each of the following periods relative to the first prescription for a topical glaucoma medication (the "index" prescription): (1) within the 4 months preceding the index prescription; (2) …”

Section: Study Populationmentioning

confidence: 99%

“…A recently published Institute of Medicine report delineating a national agenda for research on aging listed optimizing adherence to prescribed medication regimens as a research priority. 2 Glaucoma is a crucial disease entity through which to examine the issue of treatment adherence in elderly patients.…”

Section: Introdudionmentioning

confidence: 99%

Treatment for glaucoma: adherence by the elderly.

Gurwitz¹,

Glynn²,

Monane³

et al. 1993

Am J Public Health

256

172

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OBJECTIVES. The purpose of this study was to determine the extent of nonadherence to treatment for glaucoma among elderly patients. METHODS. This was a retrospective cohort study of 2440 patients older than age 65 who were enrolled in the New Jersey Medicaid Program and who were newly initiated on a topical agent for the treatment of glaucoma. Two patient-specific measures of nonadherence were employed: (1) no filled prescription for any glaucoma medication over a 12-month period after the initiation of therapy and (2) number of days without therapy for glaucoma during this 12-month period. RESULTS. By the first measure, 569 patients (23%) were found to be nonadherent. The mean number of days without therapy during the study year was 112. Factors associated with nonadherence included the use of glaucoma medication requiring more than 2 administrations per day and the presence of multiple other medications in the patient's drug regimen. Patients started on multiple glaucoma medication were more adherent than those started on a single agent. Age and sex were not found to be predictors of nonadherence. CONCLUSIONS. Substantial nonadherence was found to be common in this population. More attention to the issue of nonadherence could result in important benefits in the preservation of sight.

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“…The ethical dilemmas regarding participation of frail elderly people in clinical trials, and the question of informed consent for treatment, have exercised geriatric researchers for the past 15-20 years, as exemplified by the report of the Commission in the United States. 10 The problem is twofold: 1) Much useful research has been carried out on old people-for instance, into the effect of age or disability on functional capacity, or into the response to physical exercise in old age. (See list of references in the editorial by Blair and Garcia.)…”

Section: Participation Of Old People In Medical Researchmentioning

confidence: 99%

Subtle ethical dilemmas in geriatric management and clinical research

Rosin

Dijk²

2005

J Med Ethics

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Routine management of geriatric problems often raises ethical problems, particularly regarding autonomy of the old person. The carers or children may be unaware of the sensitivity of role reversal in dealing with the financial affairs; the need for a residential carer may compromise the old person’s privacy. Attending a day centre confers much benefit, but one must understand the old person’s resistance to change in the proposal of a new daily regimen. Similarly his or her autonomy must be the priority in planning for admittance to an old age home, and not the assumption that the family knows best. A common dilemma is the assessment of an old person’s competency in decision making, either about management of his affairs, or regarding consent to treatment, or participation in research. Because cognitive capacity is not always identical with competency, meaningful tools have recently been developed in which the emphasis is on the specific situation to be investigated.

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A National Agenda for Research on Aging

Cited by 58 publications

References 0 publications

Designing Clinical Trials of Interventions for Mobility Disability: Results From the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Trial

Designing Clinical Trials of Interventions for Mobility Disability: Results From the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Trial

Treatment for glaucoma: adherence by the elderly.

Subtle ethical dilemmas in geriatric management and clinical research

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